Shape memory drug-loading micro-nano fiber membrane capable of intelligently controlling drug release and preparation method thereof

A technology of micro-nanofibers and intelligent control, which is applied in drug delivery, pharmaceutical formulations, antibacterial drugs, etc. It can solve the problems of many times of taking drugs, short drug action time, and increased risk of drug use, and achieve intelligent control of drug release speed. , low cost and simple preparation method

Active Publication Date: 2018-05-01
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral drugs enter the target site of blood circulation after being absorbed in the gastrointestinal tract; injection administration avoids the first-pass effect of oral administration, but the risk of drug use is greatly increased. The problem with traditional drug release systems is the drug's action time Short, the number of times the patient takes the drug is large, and it is easy to overdose and cause drug poisoning

Method used

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  • Shape memory drug-loading micro-nano fiber membrane capable of intelligently controlling drug release and preparation method thereof
  • Shape memory drug-loading micro-nano fiber membrane capable of intelligently controlling drug release and preparation method thereof
  • Shape memory drug-loading micro-nano fiber membrane capable of intelligently controlling drug release and preparation method thereof

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preparation example Construction

[0026] The invention provides a method for preparing a shape-memory drug-loaded micro-nano fiber membrane capable of intelligently controlling drug release, which is specifically carried out according to the following steps:

[0027] Step S1: Dissolving the shape memory polymer material and the drug in an organic solvent, stirring until uniformly mixed to obtain an 8-13wt% electrospinning solution, wherein the mass ratio of the drug to the shape memory polymer material is 1:20-3:20 ; Preferably, the electrospinning solution also includes ferric oxide, and the mass ratio of ferric oxide to shape memory polymer material is 1:3.

[0028] Step S2: adding the electrospinning solution into the electrospinning equipment, setting the spinning parameters, and electrospinning to obtain a shape-memory drug-loaded micro-nanofiber membrane capable of intelligently controlling drug release.

[0029] The obtained shape-memory drug-loaded micro-nano fiber membrane capable of intelligently con...

Embodiment 1

[0032] This embodiment provides a method for preparing a shape-memory drug-loaded micro-nanofiber membrane capable of intelligently controlling drug release, specifically according to the following steps:

[0033] Step S1: Dissolving the polylactic acid particles of the shape memory polymer material and the antibiotic drug ciprofloxacin hydrochloride in the organic solvent chloroform solution, stirring until uniformly mixed to obtain a 10wt% electrospinning solution, in which the antibiotic drug and the polylactic acid particles The mass ratio is 1:20.

[0034] Step S2: Add the electrospinning solution into the electrospinning equipment, set the spinning voltage to 15kV, the receiving distance to 20cm, and the injection speed to 2.0ml / h, and electrospinning to obtain shape memory drug-loaded micro-nano that can intelligently control drug release Fiber membrane; the optical microscopic appearance of polylactic acid micro-nano fiber membrane loaded with ciprofloxacin hydrochlori...

Embodiment 2

[0044] This embodiment provides a method for preparing a shape-memory drug-loaded micro-nanofiber membrane capable of intelligently controlling drug release, specifically according to the following steps:

[0045] Step S1: Dissolve polylactic acid particles, a shape memory polymer material, and paclitaxel, an anticancer drug, in a mixed solution of organic solvent methylene chloride and N,N-dimethylformamide, and stir until they are evenly mixed to obtain 8wt% electrospinning Solution, wherein the mass ratio of anticancer drugs to polylactic acid particles is 3:20.

[0046] Step S2: Add the electrospinning solution to the electrospinning equipment, set the spinning voltage to 13kV, the receiving distance to 12cm, and the injection speed to 1ml / h, and electrospinning to obtain shape memory drug-loaded micro-nanofibers that can intelligently control drug release membrane.

[0047] The obtained shape-memory drug-loaded micro-nano fiber membrane capable of intelligently controlli...

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Abstract

The invention discloses a shape memory drug-loading micro-nano fiber membrane capable of intelligently controlling drug release and a preparation method thereof. Specifically, the method comprises thefollowing specific steps: S1, dissolving a shape memory polymer material and a drug into an organic solvent, and stirring to be uniformly mixed so as to obtain an electrostatic spinning solution; andS2, adding the electrostatic spinning solution into an injection pump, setting spinning parameters, and performing electrostatic spinning, thereby obtaining the shape memory drug-loading micro-nano fiber membrane. Compared with the prior art, the shape memory drug-loading micro-nano fiber membrane prepared by the method disclosed by the invention has designability, can realize preparation of micro-nano fiber membranes of multiple shape memory polymer materials and multiple drugs, is excellent in biocompatibility, biodegradable and convenient to use, and has beneficial effects of delaying thedrug release speed and controlling the drug release amount.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a shape-memory drug-loaded micro-nano fiber film capable of intelligently controlling drug release and a preparation method thereof. Background technique [0002] Shape memory polymers are smart materials that can memorize a temporary shape and return to their original shape under external stimuli. This intelligent polymer is characterized by changing shape, changing stiffness, changing size, large amount of deformation, easy processing, and low preparation cost. In particular, the biocompatibility and degradability of some polymer materials make this material have a wide range of application prospects in the field of biomedicine. [0003] As an important branch of medical applications, drug delivery systems mainly include oral drugs, injection drugs, and respiratory drug delivery. Oral drugs enter the target site of blood circulation after being absorbed in the gastrointest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K41/00A61K47/34A61K47/02A61K31/496A61P31/04
CPCA61K9/0004A61K9/0009A61K9/7007A61K31/496A61K41/00A61K41/0047A61K47/02A61K47/34
Inventor 刘彦菊张风华王亚立冷劲松夏宇良
Owner HARBIN INST OF TECH
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