Composite antibacterial aerosol as well as preparation method and application thereof

A compound antibacterial and aerosol technology, which is applied in the field of antibacterial agents, can solve the problems of complex antibacterial ingredients, cumbersome preparation procedures, and single antibacterial effect, and achieve the effect of simple formula, simple process, and improved microcirculation

Active Publication Date: 2018-05-04
青岛市中医医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a compound antibacterial aerosol and its preparation method and application, which solves the problems of complex antib...

Method used

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  • Composite antibacterial aerosol as well as preparation method and application thereof
  • Composite antibacterial aerosol as well as preparation method and application thereof
  • Composite antibacterial aerosol as well as preparation method and application thereof

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preparation example Construction

[0030] A preparation method of a composite antibacterial aerosol, comprising the following steps: a) weighing chitosan diquaternary ammonium salt, nano-scale titanium dioxide, sea salt and sodium hyaluronate, and mixing to obtain a mixture; b) obtaining in step a) Purified water is added to the mixture and stirred to make it fully dissolved to obtain a composite antibacterial aerosol.

[0031] An application of a composite antibacterial aerosol, the aerosol is used for nasal cavity, oral cavity and postoperative cleaning, and when the aerosol is used for cleaning the nasal cavity or oral cavity with congestion, the weight percentage of sea salt More than 0.9% and not more than 2.2%, when the aerosol is used for daily care of the nasal cavity or oral cavity and cleaning and nursing of postoperative wounds, the weight percentage of sea salt is 0.9%.

Embodiment 1

[0033] A kind of preparation method of chitosan diquaternary ammonium salt comprises the following steps: taking chitosan (deacetylation degree 97%, average molecular weight is 2.5 * 10 5 ) 163g, put in a high-pressure reactor, add 453g 2,3-epoxypropyltrimethylammonium chloride, 100g polyethylene glycol 400 and 1 liter of purified water, heat to 120°C, stir for 12h, after the reaction is completed , cooled to 25°C, extracted three times with ether (1L×3), added 0.5L acetone to the water phase, slowly lowered the temperature to 0°C under stirring, stirred for 2h, the product gradually precipitated during the process, and was suction filtered; the obtained solid was extracted with acetone Stir washing and drying under vacuum conditions to obtain chitosan diquaternary ammonium salt.

[0034] The output of gained chitosan diquaternary ammonium salt is 395g, and productive rate is 85%, and structural formula is:

[0035]

Embodiment 2

[0037] A preparation method of composite antibacterial aerosol, comprising the following steps:

[0038] 1) Take by weighing 3.0 g of chitosan diquaternary ammonium salt prepared in Example 1, and successively weigh 0.3 g of nanoscale titanium dioxide, 0.50 g of sodium hyaluronate and 2.2 g of sea salt, and mix to obtain a mixture;

[0039] 2) Add purified water to the above mixture until the total weight is 100g, stir to fully dissolve each component, and obtain 100g composite antibacterial aerosol.

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Abstract

The invention discloses a composite antibacterial aerosol as well as a preparation method and application thereof and belongs to the technical field of antibacterial agents. The composite antibacterial aerosol disclosed by the invention contains the following raw materials in percentage by weight: 0.5-3.0% of chitosan biquaternary ammonium salt, 0.05-0.3% of nano titanium dioxide, 0.9-2.2% of a sea salt and the balance of purified water. The invention further discloses a preparation method of the aerosol. The preparation method comprises the following steps: uniformly mixing the chitosan biquaternary ammonium salt, the nano titanium dioxide and the sea salt, adding the purified watrer, and enabling the materials to be fully dissolved, thereby obtaining the aerosol. The aerosol can be applied to cleaning of the nasal cavity and oral cavity and postoperative cleaning. The aerosol disclosed by the invention is simple in formula, low in cost, excellent in biocompatibility, simple in preparation method, obvious in antibacterial and bacteriostatic effects, safe and non-irritating, and achieves the effects of relieving inflammations of the nasal cavity and oral cavity, keeping the nasal mucosa and oral cavity wet, eliminating postoperative peripheral inflammation, preventing and controlling wound infection, promoting regeneration and repair of the mucous membranes and tissues and promoting wound healing.

Description

technical field [0001] The invention belongs to the technical field of antibacterial agents, in particular to a composite antibacterial aerosol and its preparation method and application. Background technique [0002] Chitosan, a natural polymer, has excellent properties such as biocompatibility, non-toxicity, antibacterial activity, and microbial degradability. However, chitosan has good solubility in acidic solutions and is difficult to dissolve in water. This property limits Its scope of application. At present, the research on the modification of chitosan is mainly in the C 2 -NH 2 The quaternary ammonium salt structure is introduced into the group. This chitosan quaternary ammonium salt obtained after chemical modification has good biocompatibility, not only has good water solubility, antibacterial properties, film-forming properties, and cation adsorption properties , moisture absorption, flocculation and antistatic properties, and also has excellent characteristics...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K9/12A61K47/36A61P31/02A61P1/02A61P11/02A61P17/02C08B37/08A61K31/722A61K33/14A61K31/728
CPCA61K9/0014A61K9/0043A61K9/006A61K9/12A61K31/722A61K31/728A61K33/14A61K33/24A61K47/36C08B37/003A61K2300/00
Inventor 宋磊解春霞
Owner 青岛市中医医院
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