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Nanometer cross-linked sodium hyaluronate gel, preparation method and applications thereof

A technology of cross-linking hyaluronic acid and hyaluronic acid, which is applied in the field of moisturizing masks and essences, can solve problems such as inability to enter the skin, and achieve moisturizing effect to repair skin, better moisturizing and wrinkle repair effect, and long acting time Effect

Active Publication Date: 2018-05-08
CHANGZHOU INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The cross-linked products disclosed in the above documents can only work on the surface of the skin and cannot enter the interior of the skin

Method used

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  • Nanometer cross-linked sodium hyaluronate gel, preparation method and applications thereof
  • Nanometer cross-linked sodium hyaluronate gel, preparation method and applications thereof
  • Nanometer cross-linked sodium hyaluronate gel, preparation method and applications thereof

Examples

Experimental program
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Effect test

Embodiment 1）

[0032] The average particle diameter of the nano-crosslinked hyaluronic acid gel in this embodiment is 364nm.

[0033] The preparation method of the above-mentioned nano-crosslinked hyaluronic acid gel comprises the following steps:

[0034] ① Add 25% to 45% (40wt% in this example) of 15 to 25 times its weight (20 times in this example) of cross-linked sodium hyaluronate dry powder at a temperature lower than 40°C Aqueous acetone solution, fully stirred to obtain a suspension.

[0035] The cross-linked sodium hyaluronate dry powder is first prepared by the method disclosed in the Chinese patent document CN 103923328A (application number 201410153564.9) entitled "High-quality cross-linked sodium hyaluronate gel and its preparation method". Sodium hyaluronate gel was combined, and then the gel was vacuum-dried at a temperature lower than 30°C to obtain a dry powder for future use.

[0036] ②Put the suspension obtained in step ① into a high-pressure homogenizer for 1-3 times of...

Embodiment 2）

[0045] The average particle diameter of the nano-crosslinked hyaluronic acid gel in this embodiment is 486 nm.

[0046] The rest of the preparation method of the above nano cross-linked hyaluronic acid is the same as the preparation method of the nano cross-linked hyaluronic acid in Example 1, the difference is:

[0047] What used in step ① is in the 30% acetone aqueous solution.

[0048] Step ② Send the suspension obtained in step ① into a high-pressure homogenizer for homogenization twice, and the pressure of the high-pressure homogenizer is 150Mpa.

Embodiment 3

[0049] (Example 3, Nano cross-linked sodium hyaluronate medical dressing)

[0050] The nano-crosslinked sodium hyaluronate dressing of this embodiment belongs to the second class of medical devices, including a carrier layer and a repair solution, the repair solution penetrates the carrier layer, and the weight percentage of each component in the repair solution is the hyaluronic acid composition 0.1% to 1% (0.2% in this embodiment), and the balance is PBS; the hyaluronic acid composition includes 25% to 30% (28% in this embodiment) of 100nm to 500nm nanotransplant Combined with sodium hyaluronate gel and the remaining amount of hyaluronic acid gel, the hyaluronic acid gel is composed of 10% to 20% (15% in this embodiment) hyaluronic acid gel with a molecular weight lower than 300,000 and 80% to 90% (85% in this embodiment) of hyaluronic acid gel with a molecular weight higher than 300,000, and the above contents all refer to mass percentages.

[0051] The molecular weight an...

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Abstract

The invention discloses a nanometer cross-linked sodium hyaluronate gel, a preparation method and applications thereof, wherein the particle size of the nanometer cross-linked sodium hyaluronate gel is 100-500 nm. According to the present invention, the nanometer cross-linked sodium hyaluronate gel can penetrate into the skin barrier so as to enter the deep skin layer, and is continuously decomposed into hyaluronic acid at the deep skin layer so as to completely moisturize the deep skin layer, fill fine lines, repair skin and restore elasticity; and the dressings, the mask and the skin care composition can provide functions of moisturizing and skin repairing, wherein the cross-linked sodium hyaluronate penetrating into the deep skin layer and providing functions from inside to outside andthe hyaluronic acid positioned on the skin surfacer and providing functions from outside to inside co-act to generate the functions of moisturizing and skin repairing, the action time is long, and theeffects of moisturizing, wrinkle removing and repair are excellent.

Description

technical field [0001] The invention relates to cross-linked sodium hyaluronate, in particular to a nano-cross-linked sodium hyaluronate gel and its preparation method and application, a medical dressing containing nano-cross-linked sodium hyaluronate gel, and nano-cross-linked hyaluronic acid Moisturizing Mask and Serum with Sodium Gel. Background technique [0002] Hyaluronic acid (Hyaluronic acid, hereinafter referred to as HA) is a polysaccharide, its structure is composed of β-1,3-glucose acetamide (β-1,3-N-acetylglucosamine) and β-1,4-gluconic acid (β -1,4-glucuronic acid) forms disaccharide repeat units with β-1-4 bonds, and the disaccharide repeat units are repeatedly linked with β-1-3 bonds to form a linear polymer. Commercial sodium hyaluronate (sodium hyaluronate, hereinafter referred to as SH) is the sodium salt form of HA. Hyaluronic acid is widely distributed in the extracellular matrix of animal and human connective tissue. Its random coil state in solution ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/24A61L15/42A61K8/88A61K8/73A61K8/65A61K8/64A61K8/34A61K8/04A61Q19/08A61Q19/00C08J3/075C08L5/08
CPCA61K8/042A61K8/345A61K8/64A61K8/65A61K8/735A61K8/88A61K2800/412A61L15/24A61L15/28A61L15/42A61Q19/00A61Q19/08C08J3/075C08J2305/08C08L5/08C08L33/02
Inventor 王慧何浩明管汉良朱杰高坚杰
Owner CHANGZHOU INST OF MATERIA MEDICA
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