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A surface modification method for improving corrosion resistance of magnesium alloy vascular stent

A technology for magnesium alloy stents and magnesium alloy blood vessels, applied in the field of interventional medical devices, can solve the problems of short service period and poor corrosion resistance of magnesium alloy stents, and achieve the effects of improving corrosion resistance, inhibiting excessive proliferation and realizing endothelialization

Active Publication Date: 2021-03-26
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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Problems solved by technology

[0008] The purpose of the present invention is to provide a surface modification method for improving the corrosion resistance of magnesium alloy vascular stents, on the basis of carrying out surface modification treatment on magnesium alloy vascular stents, the surface carries drugs for promoting rapid endothelialization and ( Or) genes and proteins to realize the rapid endothelialization of magnesium alloy stents after implantation, and solve the problems of poor corrosion resistance and short service life of magnesium alloy stents from another perspective

Method used

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  • A surface modification method for improving corrosion resistance of magnesium alloy vascular stent

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Embodiment 1

[0030] In this embodiment, simvastatin is selected as the drug for promoting endothelialization function, and polylactic acid is selected as the drug carrier polymer. Dissolve simvastatin and polylactic acid in an acetone solvent at a mass ratio of 1:2, mix well, and prepare a polymer drug-loaded solution with a concentration of 2 wt%. Taking the magnesium alloy stent with preliminary surface protection treatment and carrying the drug (rapamycin) for inhibiting intimal hyperplasia as the substrate, on the ultrasonic atomization spraying equipment, the ultrasonic atomization spraying method is used to coat the magnesium alloy stent substrate Preparation of magnesium alloy stents carrying dual drugs of simvastatin and rapamycin.

Embodiment 2

[0032] In this embodiment, an aqueous solution of dopamine with a concentration of 2 wt % was prepared, and a magnesium alloy stent carrying a drug (rapamycin) for inhibiting intimal hyperplasia, which had undergone preliminary surface protection treatment, was soaked in the aqueous solution of dopamine. After soaking for 2 hours, take it out and let it dry naturally in the air, that is, prepare a layer of polydopamine layer with active functional groups on the magnesium alloy stent with a coating thickness of 1 μm. Soak the 5 mm sections at both ends of the magnesium alloy stent with polydopamine in the aqueous solution for dissolving the CD34 antibody to realize the loading of the CD34 antibody on the two ends of the magnesium alloy stent. The prepared magnesium alloy stents carried CD34 antibody and rapamycin at both ends of the 5mm segment, while the middle 5mm segment only carried rapamycin.

[0033] The four stents prepared above were implanted into animal blood vessels ...

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Abstract

The invention relates to the field of interventional medical devices, and especially relates to a surface modification method for improving the corrosion resistance of a magnesium alloy intravascularstent. The method is suitable for a novel dual-drug degradable magnesium alloy intravascular stent for treating intraluminal stenosis, carrying a smooth muscle proliferation inhibitor and promoting endothelialization. The method is characterized in that a drug coating with an endothelialization promoting function is prepared on a magnesium alloy stent to accelerate the endothelialization process after stent implantation and improve the service environment of the stent, so the corrosion resistance of the magnesium alloy intravascular stent is improved. The magnesium alloy intravascular stent carries a drug for inhibiting intimal hypertrophy, and also carries a drug for promoting endothelialization. The stent can realize rapid endothelial regeneration of damaged parts through the action of the drug for promoting endothelialization after being implanted into a diseased blood vessel, so the service environment of the magnesium alloy stent is improved, and the corrosion resistance of the degradable magnesium alloy intravascular stent is improved.

Description

technical field [0001] The invention relates to the field of interventional medical devices, in particular to a surface modification method for improving the corrosion resistance of a magnesium alloy vascular stent, and is a novel magnesium alloy vascular stent suitable for the treatment of vascular stenosis and degradable and absorbable. Background technique [0002] Coronary heart disease is one of the diseases with a high incidence rate. In recent years, the incidence of coronary heart disease has tended to be younger. At present, interventional therapy is mostly used to treat coronary heart diseases such as coronary stenosis, and the application of stents has gradually developed from inert metal stents to degradable stents. Degradable stents have attracted widespread attention because they can gradually degrade and be absorbed by the body after an effective service period. . Especially for the phenomenon that the coronary heart disease population tends to be younger, de...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/14A61L31/16A61L31/10A61L31/08A61L31/02
CPCA61L31/022A61L31/08A61L31/10A61L31/14A61L31/148A61L31/16A61L2300/42C08L89/00
Inventor 陈姗姗张炳春郑丰杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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