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a porous niobium

A technology of porous niobium and porous materials, which is applied in the field of porous niobium for medical implant materials, can solve the problems of human bone tissue not growing normally, bone tissue regeneration, and bone repair materials, etc., to achieve good adhesion and effective Conducive to regeneration, uniform and stable performance

Active Publication Date: 2020-05-15
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, porous niobium is used as a medical implant material, which has little practical application and poor effect. After it is implanted into the human body, human bone tissue cannot normally grow into the implant material, that is, this implant material cannot achieve bone tissue regeneration, and cannot be used as a real implant material. bone repair material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The porous niobium in this embodiment has secondary pores, in which the uniformly distributed and interconnected first-stage cavities (large cavities) have uniformly distributed and inter-connected second-stage cavities (small cavities) on the cavity wall , and the cavities at all levels are also connected to each other. Each level of porous niobium is a continuous structure, the largest outer boundary of each level of porous niobium is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The preparation of porous niobium with secondary pore structure adopts the following method: the niobium powder, the pore-forming agent for preparing the second-level pore cavity, the binder, and distilled water are prepared in proportion to make a slurry, ultrasonically dispersed, and the slurry is coated with polyester foam Uniform impregnation, forming a green body ...

Embodiment 2

[0035] The porous niobium of this embodiment has secondary pores, wherein the uniformly distributed and interpenetrating first-level cavities have second-level cavities evenly distributed and interpenetrating on the wall of the cavity, and the cavities of each level are also mutually connected. through. Each level of porous niobium is a continuous structure, the largest outer boundary of each level of porous niobium is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The pore diameter of the smallest pore (secondary pore) is 25µm-40µm, and the pore diameter of the upper pore (first-stage pore), which is one level larger than the smallest pore diameter, is 800µm-1100µm.

[0036] Its preparation method is similar to that of Example 1, wherein the pore size of the cavity is controlled by the particle size of the pore-forming agent and the pore size of the pol...

Embodiment 3

[0039] The porous niobium of this embodiment has secondary pores, wherein the uniformly distributed and interpenetrating first-level cavities have second-level cavities evenly distributed and interpenetrating on the wall of the cavity, and the cavities of each level are also mutually connected. through. Each level of porous niobium is a continuous structure, the largest outer boundary of each level of porous niobium is equivalent to the space boundary of the entire material body, and the pores of the same level of porous material at each level are evenly distributed in the material body. The pore diameter of the smallest pore (secondary pore) is 30µm-60µm, and the pore diameter of the upper pore (first-stage pore), which is one level larger than the smallest pore diameter, is 600µm-800µm.

[0040] Its preparation method is similar to that of Example 1, wherein the pore size of the cavity is controlled by the particle size of the pore-forming agent and the pore size of the polyes...

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Abstract

The invention discloses a porous niobium. The porous niobium comprises a material main body; the material main body is a hierarchical porous material which is constituted by pore cavities which are graded in accordance with pore size and cavity walls surrounding the various grades of pore cavities, wherein the cavity wall of the upper grade of large-pore cavity is constituted by a lower grade of cavity wall structure material which is constituted by a lower grade of small-pore cavity structure smaller than the pore cavity of the grade in pore size; the pore cavities of various grades of porousmaterials mutually communicate and pore cavities of the various grades of porous materials mutually communicate; and a water contact angle of the cavity wall surface of the pore cavity of the maximumgrade of porous material of the porous niobium is not greater than 58.8 degrees, so that the hydrophilic performance of the cavity wall surface of the maximum grade of pore cavity is obviously improved, biocompatibility is enhanced, bonding of the cavity wall surface to blood and tissue fluid is promoted, protein adsorption is promoted and adhesion, growth and spreading of osteoblast are enhanced; therefore, the porous niobium is beneficial for bone tissue regeneration.

Description

technical field [0001] The present invention relates to porous materials, in particular to a porous niobium for medical implant materials. Background technique [0002] Metal niobium has high inertness and corrosion resistance, and has excellent biocompatibility and biological activity, and is very suitable as a biological implant material. Some studies have been carried out on niobium as a bioimplant material, such as Matsuno H et al Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum andrhenium . Biomaterials 2001 22:1253-1262), CN105193505A A surgical organ isolation pad provides a surgical organ isolation pad with niobium as one of the preparation materials, however, due to the high density of metal niobium, the elastic modulus It cannot be directly applied to the human body due to shortcomings such as incompatibility with human bones. Therefore, designing and manufacturing a porous niobium metal material that not only h...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/56A61L27/04A61L27/50B22F3/11
CPCA61L27/047A61L27/50A61L27/56A61L2430/02B22F3/114
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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