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A high-concentration pyridine nitrogen atom-doped carbon quantum dot and its preparation method

A technology of carbon quantum dots and pyridine nitrogen, which is applied to high-concentration pyridine nitrogen atom-doped carbon quantum dots and their preparation, and the application field of biological imaging probes, which can solve the problems of easy quenching, unstable fluorescence ability, and quantum yield. low rate and other problems, to achieve the effects of good biocompatibility, enhanced photoluminescence performance, and simple preparation method

Active Publication Date: 2020-10-16
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, carbon quantum dots have problems that limit their further applications in practice, such as unstable fluorescence, easy quenching under air or light conditions, and low quantum yield.

Method used

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  • A high-concentration pyridine nitrogen atom-doped carbon quantum dot and its preparation method
  • A high-concentration pyridine nitrogen atom-doped carbon quantum dot and its preparation method
  • A high-concentration pyridine nitrogen atom-doped carbon quantum dot and its preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Dissolve 0.05g of glucose and 3.5g of metformin hydrochloride in 50g of deionized water, place it in a high-pressure reactor, raise the temperature from room temperature to 280°C at a rate of 15°C / min, keep it warm for 10 hours, and cool naturally To room temperature, a solution containing pyrolysis products was obtained.

[0034] 2. Put the solution containing the pyrolysis product into a centrifuge tube with a volume of 10mL, centrifuge at 10000r / min for 10min, discard the sediment, and filter the supernatant with a 0.22μm water-based microporous membrane for 3 times. A transparent reddish-brown filtrate containing nitrogen-doped carbon quantum dots was obtained.

[0035] 3. Put the filtrate containing nitrogen-doped carbon quantum dots into a regenerated cellulose dialysis bag with a molecular weight cut-off of 5000D, and dialyze it through deionized water for 48 hours. Drying at 60° C. and a pressure of 0.1 MPa to a constant weight yields high-concentration pyri...

Embodiment 2

[0043] 1. Dissolve 0.05g of glucose and 0.276g of metformin hydrochloride in 50g of deionized water, place them in a high-pressure reactor, raise the temperature from room temperature to 240°C at a rate of 30°C / min, keep it warm for 2 hours, and cool naturally To room temperature, a solution containing pyrolysis products was obtained.

[0044] 2. Put the solution containing the pyrolysis product into a centrifuge tube with a volume of 10mL, centrifuge at 10000r / min for 10min, discard the sediment, and filter the supernatant with a 0.22μm water-based microporous membrane for 3 times. A transparent reddish-brown filtrate containing nitrogen-doped carbon quantum dots was obtained.

[0045] 3. Put the filtrate containing nitrogen-doped carbon quantum dots into a regenerated cellulose dialysis bag with a molecular weight cut-off of 3500D, and dialyze it with deionized water for 48 hours. Drying at 60° C. and a pressure of 0.1 MPa to a constant weight yields high-concentration pyri...

Embodiment 3

[0047] 1. Dissolve 0.1g of glucose, 0.2g of citric acid and 0.15g of diethylenetriaminepentaacetic acid in 50g of deionized water, place it in a high-pressure reactor, and raise the temperature from room temperature at a rate of 30°C / min to 240°C, keep warm for 2 hours, and cool down to room temperature naturally to obtain a solution containing pyrolysis products.

[0048] 2. Put the solution containing the pyrolysis product into a centrifuge tube with a volume of 10mL, centrifuge at 10000r / min for 10min, discard the sediment, and filter the supernatant with a 0.22μm water-based microporous membrane for 3 times. A transparent reddish-brown filtrate containing nitrogen-doped carbon quantum dots was obtained.

[0049] 3. Put the filtrate containing nitrogen-doped carbon quantum dots into a regenerated cellulose dialysis bag with a molecular weight cut-off of 1000D, dialyze through deionized water for 48 hours, and concentrate the dialysate by rotary evaporation at 60°C for 2 hou...

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Abstract

The invention discloses high-concentration pyridine-nitrogen-atom-doped carbon quantum dots and a preparation method thereof. The doped carbon quantum dots take carbon source and nitrogen source organic compounds as a precursor and are prepared via a green eco-friendly one-step hydrothermal method, thereby guaranteeing that pyridine nitrogen atoms are doped into the inner structure and external surface of the carbon quantum dots. The preparation method is simple and easy to operate, the reaction condition is easy to control, and organic reagents are not required. The diameter of the doped carbon quantum dots is 1.5-6 nm. The doped carbon quantum dots can be uniformly stably dispersed in deionized water, are excellent in photoluminescence performance, and have the quantum yield reach 39.8%.The doped carbon quantum dots are green and non-toxic, are excellent in biocompatibility, can enter cell membranes for imaging, and are suitable for preparing biomedical imaging probes.

Description

technical field [0001] The invention belongs to the technical field of preparation of medical imaging materials, and in particular relates to a high-concentration pyridine nitrogen atom-doped carbon quantum dot and its preparation method, as well as its application in biological imaging probes. Background technique [0002] Traditional imaging technologies, such as semiconductor quantum dot imaging technology used in clinical practice, are toxic due to the presence of cadmium or other heavy metals, which limits their further promotion and application. Fluorescent carbon quantum dots amplify the advantages of molecular imaging technology due to their good biocompatibility, excellent optical properties and precise biological targeting. They are used as biomedical probes to overcome the limitations of traditional imaging techniques and broaden the scope of research. Research scope and application prospect of molecular imaging technology. Moreover, fluorescence imaging technolo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09K11/65C01B32/15B82Y20/00B82Y40/00
CPCB82Y20/00B82Y40/00C01P2004/64C01P2006/60C09K11/65
Inventor 任雪艳任先艳孔庆军王超梁颖
Owner SHAANXI NORMAL UNIV
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