H5 subtype avian influenza vaccine strain capable of distinguishing immunized and infected animals, and preparation method and application thereof

A technology for avian influenza and vaccine strains, which is applied in the field of preparing vaccine strains for distinguishing immunity and infection of H5 subtype avian influenza, can solve the problems of inability to completely eliminate highly pathogenic avian influenza, antigenic drift, and antigenicity differences of vaccine strains, and achieve Highlight the significance of public health safety, avoid antigenic variation, good replication and growth effects
CN108103084AActive Publication Date: 2018-06-01ZHEJIAN DIFFERENCE BIOLOGICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ZHEJIAN DIFFERENCE BIOLOGICAL TECH CO LTD
Publication Date
2018-06-01

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Abstract

The invention discloses an H5 subtype avian influenza vaccine strain capable of distinguishing immunized and infected animals, and a preparation method and application thereof. Highly-pathogenic H5 subtype avian influenza brings in great economic loss to the animal husbandry and poses a severe threat to public health. Although conventional H5 subtype avian influenza totivirus inactivated vaccineshave the advantages of definite effect, low cost, a wide application scope and the like, but cannot serologically distinguish immunized and infected animals, which brings in great obstacles for monitoring and purifying of avian influenza. According to the invention, the NA of B type influenza is used as a label so as to successfully establish the method for constructing the H5 subtype avian influenza vaccine strain capable of distinguishing immunized and infected animals. The H5 subtype avian influenza vaccine strain has critical application value and public health significance to prevention,control and purification of H5 subtype avian influenza.
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Description

technical field

[0001] The invention belongs to the technical field of genetic engineering vaccines, and relates to a method and application for preparing vaccine strains for distinguishing immunity and infection of H5 subtype avian influenza. Background technique

[0002] Avian influenza viruses belong to the family Orthomyxoviridae and the genus Influenzavirus. Influenza viruses can be divided into A, B, and C types according to their antigenicity. Type A influenza has a wide range of hosts (including birds, humans, pigs, etc.) and is more pathogenic and harmful. Influenza B only infects humans and seals, and its pathogenicity is relatively low. Type C influenza virus, found only in humans and pigs. The genomes of influenza A and B can be divided into eight gene segments: PB2, PB1, PA, NP, HA, NA, M, and NS. After the host is infected, a large number of antibodies can be produced against HA, NA, M1 and NP. Among them, HA can directly induce the main neutralizing antibo...

Claims

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