Glycine chelated calcium tablet composition and preparation method thereof

A technology of chelating calcium and glycine, which is applied in the directions of drug combination, non-active ingredients of polymer compounds, and pill delivery, etc., can solve the problems that calcium-containing preparations have not made breakthrough progress, and glycine-chelated calcium has not been able to exert its efficacy. Suitable for mass production, good dissolution, low cost of raw materials

Active Publication Date: 2018-06-08
天津市索源化学生物技术有限公司
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there has been no breakthrough in the research on calcium-containing preparations, and due to the influence of the preparation

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Glycine chelated calcium tablet composition and preparation method thereof
  • Glycine chelated calcium tablet composition and preparation method thereof
  • Glycine chelated calcium tablet composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 prepares glycine chelated calcium tablet

[0042] Prescription (based on 1000 tablets)

[0043] raw material

[0044] The preparation method is as follows: grind glycine chelated calcium, weigh the raw materials and pass through a 100-mesh sieve; dissolve methyl cellulose in purified water to prepare a 0.5% w / v aqueous solution, and dissolve gelatin in purified water to prepare a 10% w / v solution gelatin paste. Stir the crushed glycine chelated calcium, starch and powdered sugar, then add 0.5% w / v methylcellulose aqueous solution and 10% w / v gelatin slurry, wet granulate with a 16-mesh screen, and dry at 60°C Pass through a 12-mesh sieve for granulation, add magnesium stearate and compress into tablets.

Embodiment 2

[0045] Embodiment 2 prepares glycine chelated calcium tablet

[0046] Glycine chelated calcium tablets were prepared in the same manner as in Example 1, except that the prescription shown below was adjusted:

[0047] Prescription (based on 1000 tablets)

[0048] raw material

Embodiment 3

[0049] Embodiment 3 prepares glycine chelated calcium tablet

[0050] Glycine chelated calcium tablets were prepared in the same manner as in Example 1, except that the prescription shown below was adjusted:

[0051] Prescription (based on 1000 tablets)

[0052] raw material

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a glycine chelated calcium tablet composition which is prepared from glycine chelated calcium, a diluent, a disintegrant, a lubricant and an adhesive, wherein the adhesive isselected from a composition of gelatin and a cellulose adhesive. The invention also discloses a preparation method thereof. The preparation method comprises the following steps: 1) crushing the glycine chelated calcium raw material; 2) preparing gelatin slurry and a cellulose adhesive aqueous solution; 3) mixing the glycine chelated calcium, the diluent and the disintegrant and adding the adhesive, and carrying out wet process granulation; and 4) adding the lubricant after drying and granulating, and carrying out tabletting. The tablet is simple in preparation method and high in dissolution rate.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically discloses a glycine complex calcium tablet and a preparation method thereof. Background technique [0002] Calcium is an essential element for living things. Calcium is the main inorganic component of human bones and teeth, and is also an essential element for nerve transmission, muscle contraction, blood clotting, hormone release and milk secretion. Calcium accounts for about 1.4% of the body's mass and participates in metabolism. Calcium must be supplemented every day; insufficient or excess calcium in the human body will affect growth and health. In the human body, 99% of calcium is present in bones and teeth as bone salt. Bone is the main site of calcium deposition, so it is called "calcium pool". Bone calcium mainly exists in two forms: amorphous calcium hydrogen phosphate and crystalline hydroxyapatite, and its composition and physical and chemical properties a...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/20A61K31/198A61K47/42A61K47/38A61P3/02
Inventor 李宝恒李倩
Owner 天津市索源化学生物技术有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap