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Qingcijian esterol sublingual tablet and preparation method thereof

A kind of technology of penicillium sharp ester alcohol and sublingual tablet, which is applied in the direction of medical formula, medical preparation of non-active ingredients, drug combination, etc., to achieve the effect of excellent antipyretic and anti-inflammatory, reasonable formula and convenient application

Active Publication Date: 2019-08-13
成植温
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Prinsepiol is a double-epoxy lignin compound extracted from Prinsepiol, and there is no report that it has antipyretic, analgesic, and anti-inflammatory effects

Method used

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  • Qingcijian esterol sublingual tablet and preparation method thereof
  • Qingcijian esterol sublingual tablet and preparation method thereof
  • Qingcijian esterol sublingual tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation of Penicillium thorn ester alcohol-DM-β-cyclodextrin inclusion compound

[0020] Accurately weigh 2.0g of DM-β-cyclodextrin, add 25mL of distilled water, heat and stir in a water bath at a certain temperature, and dissolve to obtain a saturated DM-β-cyclodextrin solution. Dissolve completely with water and ethanol, slowly add the ethanol solution to the saturated DM-β-cyclodextrin solution dropwise, heat and stir at a constant temperature of 50°C for 2 hours, centrifuge, filter, and dry to obtain the echinacea Ester alcohol-DM-β-cyclodextrin inclusion compound.

Embodiment 2

[0021] The preparation of embodiment 2 Qingci sharp ester alcohol sublingual tablet

[0022] (1) Weigh 100g of the thorny ester alcohol-DM-β-cyclodextrin inclusion compound, 200g of lactose, 60g of polyethylene glycol 400, 80g of sodium carboxymethyl starch, 60g of menthol, and 10g of magnesium stearate, Pass through an 80-mesh sieve for later use, make soft materials, pass through a 30-mesh sieve, granulate, dry, and granulate, add magnesium stearate and mix evenly, press 1000 tablets to obtain Qingcijian Esterol Sublingual Tablets a (500mg per tablet, Each tablet contains 0.1g clathrate, containing 0.02g green thorn ester alcohol).

[0023] (2) Weigh 100g of thorny thorn ester alcohol-DM-β-cyclodextrin inclusion compound, 220g of starch, 60g of polyethylene glycol 400, 90g of microcrystalline cellulose, 55g of menthol, 15g of talcum powder, and pass through 80 mesh Sieve for later use, make soft materials, pass through a 30-mesh sieve, granulate, dry, granulate, add magnesi...

Embodiment 3

[0025] Example 3 Analgesic Effect Test of Qingcijian Esterol Sublingual Tablets

[0026] 50 Kunming female mice were randomly divided into the following 5 groups, 10 in each group, and the corresponding dosage was converted according to the equivalent dose conversion formula between animals and humans as follows: (1) Physiological Saline (5ml·kg -1 ); (2) Embodiment 2 Qingcijian Esterol sublingual tablet a low dose group (125mg·kg -1 ); (3) dosage group (250mg·kg -1 ); (4) Embodiment 2 Qingcijian Esterol sublingual tablet a high dose group (500mg·kg -1 ); (5) positive control group ibuprofen tablets (250mg·kg -1 ). Oral administration. Place the mice on a hot plate pain measuring instrument at (55±1)°C, and record the time immediately until the first hind paw licking or stomping occurs, and the obtained time is the basic pain threshold. Animals whose basic pain threshold was greater than 5 seconds and less than 30 seconds were selected for the experiment, and no licking ...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a prinsepiol sublingual tablet and a preparation method thereof. The prinsepiol sublingual tablet comprises 1-10 parts of prinsepiol cyclodextrin inclusion, 15-20 parts of filling agent, 1-5 parts of polyethylene glycol 400, 1-6 parts of disintegrant, 1-5 parts of corrigent and 0.5-5 parts of lubricant. Application of prinsepiol in preparing medicine compositions with antipyretic, analgesic and anti-inflammatory functions is provided for the first time. It is proved through a mouse hot plate method and rat carrageenin caused foot swelling experiments that prinsepiol has excellent antipyretic and anti-inflammatory functions. The novel preparation of the prinsepiol sublingual tablet is provided for the first time, the formula is reasonable, the dissolution rate, the disintegration degree and stability tests meet the requirements, and the excellent antipyretic and anti-inflammatory effects are obtained; the prinsepiol sublingual tablet is very convenient to use, is taken by a patient sublingually, is high in compliance and can reduce the pressure of conventional tablet taking, andthe sublingual tablet makes people have an psychological effect of enhancing the antipyretic and anti-inflammatory functions.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to Qingcijian Esterol sublingual tablets and a preparation method thereof. Background technique [0002] Antipyretic and analgesic anti-inflammatory drugs are a class of antipyretic and analgesic drugs, most of which also have anti-inflammatory and anti-rheumatic effects. These are called non-steroidal anti-inflammatory drugs (NSAIDs). [0003] Antipyretic, analgesic and anti-inflammatory drugs have become indispensable and important drugs in human daily life, and are one of the most widely used and most widely used pharmaceutical products in the world. At present, there are many types of antipyretic, analgesic and anti-inflammatory drugs in the world, and there are dozens of varieties, but they all have common pharmacological effects such as antipyretic, analgesic, anti-inflammatory and anti-rheumatic. The mechanism of action of antipyretic and ana...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/34A61K47/69A61K9/20A61P29/00
CPCA61K9/006A61K9/2031A61K31/34
Inventor 成植温董宁霞魏雯雯刘长民耿海涛宁方玲
Owner 成植温
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