Scaffold for repairing joints

A joint and salt layer technology, applied in the field of prostheses, can solve problems such as unreasonable repair scaffold structure, poor repair and regeneration effects, unsatisfactory force transmission, etc., to achieve excellent mechanical properties, good force transmission, strong resistance The effect of pressure

Active Publication Date: 2018-06-26
CHONGQING RUNZE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Although people have carried out a lot of research, the structure of the joint repair scaffold as cartilage and subchondral bone is still unreasonable, and it has not effectively mimicked human joints. There is no function of each layer of cartilage or the function is quite different from natural cartilage. The transmission is not ideal, the bracket is easy to be damaged, and some of them are not strong enough, and the effect of repair and regeneration is not good

Method used

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  • Scaffold for repairing joints
  • Scaffold for repairing joints
  • Scaffold for repairing joints

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The scaffold for joint repair in this embodiment is composed of a porous polymer material layer 1 , a porous salt layer 2 and a porous metal material layer 3 in sequence from top to bottom. The porous polymer material layer 1 is a mixture of polylactic acid as the matrix and calcium polyphosphate short fibers, with a pore size of 3-10 μm, a porosity of 72%, and a thickness of 2.5 mm. The porous salt layer 2 is a porous inorganic salt layer, which uses porous hydroxyl Apatite, its pore size is 3μm-5μm, porosity is 40%, and thickness is 0.8mm; Porous metal material layer 3 is porous titanium, wherein porous titanium has two layers, see figure 2 , where the upper layer 4 (first layer) connected to the porous salt has a pore size of 50 μm-70 μm, a porosity of 35%, and a thickness of 2 mm, and the lower layer 5 (second layer) has a pore size of 100 μm-400 μm and a porosity of 85 %, the thickness is 4mm. The preparation method of the bracket for joint repair is as follows: ...

Embodiment 2

[0050] The scaffold for joint repair of this embodiment is similar to that of Embodiment 1, except that the porous metal material layer is a porous nickel-titanium alloy, the pore diameter of the first layer is 80 μm-100 μm, the pore diameter of the second layer is 800 μm-1000 μm, and the porous hydroxyl The pore diameter of the apatite is 5 μm-10 μm, and the porous polymer material layer adopts type II collagen and chitosan, and the pore diameter is 3-20 μm. The preparation method is similar to that of Example 1, except that when preparing the porous polymer material layer, a slurry made of type II collagen and chitosan is spread on the surface of the porous salt layer, and then freeze-dried to form a porous gel.

Embodiment 3

[0052] The scaffold for joint repair in this embodiment is composed of a porous polymer material layer, a porous salt layer and a porous metal material layer in sequence from top to bottom. The porous metal material layer is porous niobium, wherein the porous niobium is a gradient porous material, wherein the pore diameter of the surface close to the porous salt layer is 50 μm-80 μm, and the pore diameter of the distal surface of the porous niobium away from the porous salt layer is 100 μm-500 μm. The ratio is 78%, and the thickness is 7mm. The porous polymer material layer is divided into three layers. The bottom layer 8 close to the porous salt layer is made of type I collagen and hyaluronic acid, with a pore size of 10 μm-20 μm, a porosity of 60%, and a thickness of 1.5 mm. Collagen and hyaluronic acid, the pore size is 3μm-10μm, the porosity is 52%, the thickness is 1mm, the top layer 6 uses type I collagen, the maximum size of the pores is 5μm, the porosity is 45%, and th...

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Abstract

The invention discloses a scaffold for repairing joints. The scaffold is composed of a porous polymer material layer, a porous salt layer and a porous metal material layer from top to bottom. Throughthe biomimetic means and reasonable design of the porous polymer material layer, porous salt layer and porous metal material structures, the subchondral bone and articular cartilage are simulated, good force transmission is realized, excellent mechanical properties and good percolation characteristics are obtained, colonization, differentiation and proliferation of chondrocytes are promoted and the scaffold is an excellent scaffold for cartilage-subchondral bone repair.

Description

technical field [0001] The invention relates to a prosthesis, in particular to a bracket for joint repair. Background technique [0002] Human joints have a complex structure, including cartilage, subchondral bone, etc. Cartilage includes superficial layer, middle layer, deep layer, and calcified layer. The structures of each layer are very different, and different regions have different mechanical properties. Complex loads, when exercising, the loads on the joints even reach 7-9 times of the human body weight, which puts high demands on the articular cartilage and subchondral bone. The incidence of bone and cartilage caused by trauma and social aging continues to increase. Trauma, osteoarthritis, etc. can cause damage or defect of cartilage and subchondral bone. Cartilage and subchondral bone injuries have become more common diseases in orthopedics. Studies have shown that the repair ability of adult articular cartilage is very limited. A series of experiments have confir...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/20A61L27/18A61L27/12A61L27/06A61L27/04A61L27/50A61L27/56
CPCA61L27/047A61L27/06A61L27/12A61L27/18A61L27/20A61L27/24A61L27/50A61L27/56A61L2300/412A61L2430/06A61L2430/24C08L67/04C08L5/08C08L5/12
Inventor 叶雷
Owner CHONGQING RUNZE PHARM CO LTD
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