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Micro-needle and micro-needle patch

A technology of microneedle stickers and microneedles, applied in the field of microneedles, can solve problems such as insufficient hardness and toughness, harmful cells, and easy breakage, and achieve the effect of strong hardness and toughness, easy penetration, and not easy to break

Inactive Publication Date: 2018-07-06
NANJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, although dextran has good biocompatibility and biodegradability, due to its insufficient hardness and toughness, when used as a material for microneedles, it is often easy to break and difficult to penetrate the skin
Moreover, how to effectively control the carrying amount of active ingredients of traditional Chinese medicine or vaccines in microneedle patches is also a difficult problem, and the existing process methods still need to be improved.
[0007] In addition, in the prior art, N,N-methylene acrylamide, dicumyl peroxide, etc. are often used as cross-linking agents, and these chemical substances cannot be degraded in the human body and are harmful to cells

Method used

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  • Micro-needle and micro-needle patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Dissolve the dried and purified dextran powder (molecular weight 5000) in deionized ultrapure water to a final concentration of 30g / L, add tannic acid powder to a final concentration of 2g / L, and quickly mix on a vortex mixer , and reacted at 20° C. for 20 minutes to obtain a matrix solution.

[0043] (2) Adding ciprofloxacin to the matrix solution so that the mass fraction of ciprofloxacin is 30%.

[0044] (3) Rapidly inject the mixed solution obtained in step (2) into the tiny depression of the PDMS mold with a syringe or a capillary dispenser. The depressions on the PDMS mold are conical, and the density is 100 / cm 2 , each depression has a width of 20 μm and a depth of 100 μm.

[0045] (4) Put the whole mold into an oven, and dry at 60°C for 4 hours.

[0046] (5) Gently take out the formed microneedle from the tiny depression of the mold.

Embodiment 2

[0048] First, the PDMS mold was prepared as follows:

[0049] First prepare a stainless steel male mold containing multiple conical protrusions, the density of the conical protrusions is 2 / cm 2 , each conical protrusion has a width of 200 μm (conical bottom) and a depth of 20 μm. Press the stainless steel male mold on the flat surface of the formed PDMS cube, so that the conical protrusion penetrates into the PDMS to form a conical depression. At this time, the PDMS block is the PDMS mold.

[0050] (1) Dissolve the dried and purified dextran powder (molecular weight 9000) in deionized ultrapure water to a final concentration of 10g / L, add tannic acid powder to a final concentration of 3g / L, and quickly mix on a vortex mixer , reacted at 23° C. for 30 min to obtain a matrix solution.

[0051] (2) Add functional genes to the matrix solution so that the mass fraction of the functional genes is 40%, and add butyl hydroxytoluene so that butyl hydroxytoluene accounts for 0.01% of...

Embodiment 3

[0055] First, the PDMS mold was prepared as follows:

[0056] First prepare a stainless steel male mold containing multiple conical protrusions, the density of the conical protrusions is 50 / cm 2 , each conical protrusion has a width of 1000 μm (conical bottom) and a depth of 1000 μm. Press the stainless steel male mold on the flat surface of the formed PDMS cube, so that the conical protrusion penetrates into the PDMS to form a conical depression. At this time, the PDMS block is the PDMS mold.

[0057] (1) Dissolve the dried and purified dextran powder (molecular weight: 10,000) in deionized ultrapure water to a final concentration of 20g / L, add tannic acid powder to a final concentration of 4g / L, and mix quickly on a vortex mixer , and reacted at 25° C. for 60 min to obtain a matrix solution.

[0058] (2) add levofloxacin in described substrate solution, make the massfraction of levofloxacin be 65%, add butyl hydroxyanisole and α-tocopherol, make the total mass of butyl hy...

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Abstract

The invention relates to a micro-needle and a micro-needle patch. The micro-needle comprises a matrix and active components, wherein the matrix takes the shape of a micro-needle; the active componentsare coated by the matrix; the matrix is hydrogel prepared from glucan and tannic acid through polymerization; the active components are substances with medical and cosmetic effects; when the patch isapplied to skin, the micro-needle can be inserted into the skin through slight pressing of thumbs, and then the treatment active components can be continuously released. By adopting the micro-needleand the micron-needle patch, percutaneous delivery of pharmacological active substances can be effectively carried out without highly skilled operation or pain. The glucan and a tannin polymer are ofnetwork structures with relatively good hardness and toughness, so that the micro-needle made of the components is not easily broken, and can relatively easily penetrate through skin cuticles.

Description

technical field [0001] The present invention relates to microneedles, and in more detail, relates to microneedles and microneedles for transdermally administering active substances of pharmaceutical, medical or cosmetic effects using non-toxic, biodegradable, biocompatible dextran of biological origin and Microneedle patches. Background technique [0002] Common modes of administration mainly include oral administration and injection administration. Oral administration is the most convenient way of administration, but due to some hydrolytic enzymes in the stomach and first-pass metabolism in the liver, it cannot achieve therapeutic effects for some protein drugs. Injection administration requires highly skilled physicians, is not safe for pain, and produces sharp medical waste. [0003] Transdermal drug delivery is a drug delivery method that has attracted attention in recent years. Utilize the microneedle device whose diameter and height are limited to tens or hundreds o...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/496A61K31/5383A61K31/616A61K47/26A61K47/36A61K8/02A61K8/60A61K8/73A61M37/00A61Q19/00
CPCA61K8/0204A61K8/60A61K8/73A61K9/0021A61K31/496A61K31/5383A61K31/616A61K47/26A61K47/36A61M37/0015A61Q19/00A61K2800/91A61M2037/0053A61M2037/0046A61K31/05A61K31/355Y02A50/30
Inventor 姜岷古蕾方艳马江锋信丰学
Owner NANJING UNIV OF TECH
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