Veterinary enteric composition and preparation method thereof
A composition and enteric-coated technology, which is applied in the direction of drug combinations, active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, etc., can solve the problem of few bioadhesive drug delivery systems and no poultry coccidiosis bioadhesive With drug delivery system and other issues, to achieve the effect of convenient drug use, long action time and stable gel strength
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
Embodiment 1
[0028] Weigh the toltrazuril, skeleton material, and adhesive material in a mass ratio of 2:6:5. The skeleton material is stearyl alcohol and PEG6000 with a mass ratio of 1:3, the adhesive material is carbopol934 and coumarin gum with a mass ratio of 5:2, and the enteric coating material is acrylic resin solution; mix stearyl alcohol and PEG6000, and Mix and heat at 85°C to melt, add toltrazuril fine powder, stir for 1 hour, mix well, cool until completely solidified, vacuum-dry to 3% moisture, grind, pass through 80-mesh sieve to make dispersed powder; take carbopol934 and coumarin powder and mix After homogeneity, it is uniformly mixed with dispersible powder in equal increments, passed through a 40-mesh sieve, added with 2% microcrystalline cellulose and 1.5% magnesium stearate, the tableting strength is 8 kN, and the powder is directly compressed into a bioadhesive with a diameter of 7 mm. type inner core; prepare an enteric coating material acrylic resin solution, spray t...
Embodiment 2
[0030]Weigh toltrazuril, skeleton material, and adhesive material in a mass ratio of 3:5:4. The skeleton material is octadecyl alcohol and PEG6000 with a mass ratio of 1.5:5, the adhesive material is cocoa gum, and the enteric coating material is acrylic resin solution; mix stearyl alcohol and PEG6000, mix and heat at 90°C for melting, and add Quzhuli fine powder, stirred for 1 hour, mixed evenly, cooled to complete solidification, vacuum-dried to 2% moisture, then ground, passed through an 80-mesh sieve to make a dispersed powder; take the coumarin powder, and mix evenly with the dispersed powder in equal amounts , through a 40-mesh sieve, add 5% microcrystalline cellulose and 0.5% magnesium stearate, 11 kN tablet strength, powder direct compression method to make a bioadhesive inner core with a diameter of 7mm; prepare enteric coating material acrylic resin solution, spray the enteric coating material on the surface of the bioadhesive inner core, increase the weight of the c...
Embodiment 3
[0031] Example 3 In vitro bioadhesion performance test of the veterinary enteric composition prepared in the embodiment of the present invention
[0032] experiment method:
[0033] 1. In vitro adhesion test:
[0034] Take a rabbit that has fasted for 24 hours, and kill it by injecting air into the ear vein. Take the small intestine, wash it with pH6.8 phosphate buffer to remove the content, cut it into small pieces, and store it in a -20°C refrigerator. The night before the experiment Thaw in a refrigerator at 4°C and allow to cool to room temperature before experimentation.
[0035] The experiment was divided into 7 groups: 1 control group (common preparation of toltrazuril) and 6 experimental groups (3 groups of compositions prepared in Example 1, 3 groups of compositions prepared in Example 2). Take 7 pieces of intestinal mucosa and fix them on 7 thin slices A with hooks respectively. Take 1 piece of toltrazuril ordinary preparation, 3 pieces of the composition adhered ...
PUM
Property | Measurement | Unit |
---|---|---|
Diameter | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com