Veterinary enteric composition and preparation method thereof

A composition and enteric-coated technology, which is applied in the direction of drug combinations, active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, etc., can solve the problem of few bioadhesive drug delivery systems and no poultry coccidiosis bioadhesive With drug delivery system and other issues, to achieve the effect of convenient drug use, long action time and stable gel strength

Active Publication Date: 2018-07-20
JIANGSU LINGYUN PHARMA
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are few studies on bioadhesive drug delivery system for poultry
At present, there is no research report on a highly targeted bioadhesive drug delivery system for the treatment of poultry coccidiosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Weigh the toltrazuril, skeleton material, and adhesive material in a mass ratio of 2:6:5. The skeleton material is stearyl alcohol and PEG6000 with a mass ratio of 1:3, the adhesive material is carbopol934 and coumarin gum with a mass ratio of 5:2, and the enteric coating material is acrylic resin solution; mix stearyl alcohol and PEG6000, and Mix and heat at 85°C to melt, add toltrazuril fine powder, stir for 1 hour, mix well, cool until completely solidified, vacuum-dry to 3% moisture, grind, pass through 80-mesh sieve to make dispersed powder; take carbopol934 and coumarin powder and mix After homogeneity, it is uniformly mixed with dispersible powder in equal increments, passed through a 40-mesh sieve, added with 2% microcrystalline cellulose and 1.5% magnesium stearate, the tableting strength is 8 kN, and the powder is directly compressed into a bioadhesive with a diameter of 7 mm. type inner core; prepare an enteric coating material acrylic resin solution, spray t...

Embodiment 2

[0030]Weigh toltrazuril, skeleton material, and adhesive material in a mass ratio of 3:5:4. The skeleton material is octadecyl alcohol and PEG6000 with a mass ratio of 1.5:5, the adhesive material is cocoa gum, and the enteric coating material is acrylic resin solution; mix stearyl alcohol and PEG6000, mix and heat at 90°C for melting, and add Quzhuli fine powder, stirred for 1 hour, mixed evenly, cooled to complete solidification, vacuum-dried to 2% moisture, then ground, passed through an 80-mesh sieve to make a dispersed powder; take the coumarin powder, and mix evenly with the dispersed powder in equal amounts , through a 40-mesh sieve, add 5% microcrystalline cellulose and 0.5% magnesium stearate, 11 kN tablet strength, powder direct compression method to make a bioadhesive inner core with a diameter of 7mm; prepare enteric coating material acrylic resin solution, spray the enteric coating material on the surface of the bioadhesive inner core, increase the weight of the c...

Embodiment 3

[0031] Example 3 In vitro bioadhesion performance test of the veterinary enteric composition prepared in the embodiment of the present invention

[0032] experiment method:

[0033] 1. In vitro adhesion test:

[0034] Take a rabbit that has fasted for 24 hours, and kill it by injecting air into the ear vein. Take the small intestine, wash it with pH6.8 phosphate buffer to remove the content, cut it into small pieces, and store it in a -20°C refrigerator. The night before the experiment Thaw in a refrigerator at 4°C and allow to cool to room temperature before experimentation.

[0035] The experiment was divided into 7 groups: 1 control group (common preparation of toltrazuril) and 6 experimental groups (3 groups of compositions prepared in Example 1, 3 groups of compositions prepared in Example 2). Take 7 pieces of intestinal mucosa and fix them on 7 thin slices A with hooks respectively. Take 1 piece of toltrazuril ordinary preparation, 3 pieces of the composition adhered ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention provides a veterinary enteric composition, comprising a bioadhesive inner core and an enteric outer layer, wherein the bioadhesive inner core is prepared from toltrazuril, a framework material and an adhesive material; the enteric outer layer is prepared from an enteric coating material; the veterinary enteric composition is also prepared from pharmaceutically acceptable auxiliary materials. The invention also provides a preparation method of the composition; toltrazuril enteric bioadhesive sustained-release tablets are prepared by combining a bioadhesive technology with an enteric sustained-release technology. The veterinary enteric composition provided by the invention can directly reach the lesion, and can stay in poultry bodies for a longer time after being taken for once; the veterinary enteric composition has the dual functions of intestinal positioning and bioadhesion, can be released in a sustained way in the intestines, and is long in acting time and high in stability; therefore, the frequency of medication is reduced, and the medication is facilitated.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a veterinary enteric-coated composition and a preparation method thereof. Background technique [0002] Coccidiosis is a common intestinal parasitic protozoan disease of poultry and livestock. It mainly parasitizes in the intestinal epithelial cells of chickens, pigeons, rabbits, pigs, and dogs. Since the intestinal tract is an important digestive and absorption organ, the parasites multiply Proliferation leads to intestinal tissue damage and thickening of the intestinal wall in poultry and livestock. The specific symptoms are: poor spirits, abdominal distension, diarrhea, blood in the stool, convulsions and even death. Because coccidiosis seriously affects the digestion and absorption of feed by poultry and livestock, the feeding efficiency is reduced, the feed remuneration is reduced, and huge economic losses are caused to poultry and livestock breeding. And the greater harm...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/36A61K9/32A61K9/22A61K31/53A61K31/736A61K47/10A61K47/36A61K47/38A61K47/32A61P33/02
CPCA61K9/0065A61K9/2013A61K9/205A61K9/284A61K9/2866A61K31/53A61K31/736A61K2300/00
Inventor 凌青云毕亚铃蒋忠良
Owner JIANGSU LINGYUN PHARMA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products