Polyethylene glycol-polyethyleneimine modified ferric oxide nanoparticle preparation method

Abstract

The invention discloses a polyethylene glycol-polyethyleneimine modified ferric oxide nanoparticle preparation method which comprises the following steps: 1) dissolving polyethylene glycol into dichloromethane, adding maleic anhydride, adding triethylamine and 4-dimethylamino pyridine at the same time, reacting for 48h to 72h under the room temperature condition and adding ice diethyl ether precipitate to obtain a product carboxylated polyethylene glycol; 2) dissolving the product into tetrahydrofuran, adding polyethyleneimine, adding dicyclohexyl carbodiimide and 4-dimehtylamino pyridine, reacting for 72h to 120h under room temperature and performing rotary evaporation to remove a solvent to obtain polyethylene glycol-polyethyleneimine copolymer; 3) obtaining polyethylene glycol-polyethyleneimine modified ferric oxide nanoparticles through a ligand exchange method. The ferric oxide nanoparticles prepared by the preparation method disclosed by the invention has the advantages of even particle size distribution and good water solubility and cytocompatibility.

Description

technical field [0001] The invention belongs to the field of material technology, and in particular relates to a preparation method of polyethylene glycol-polyethyleneimine modified iron oxide nanoparticles. Background technique [0002] Iron oxide nanoparticles (Iron Oxide Nanoparticles) are widely used in magnetic energy storage media, biosensors, drug loading, and medical treatment. In medical treatment applications, the colloidal stability of iron oxide nanoparticles is the main performance index affecting its application [International J.Pharmaceutics.2011,408,130]. It is an effective method to modify the surface of iron oxide nanoparticles. For example, polyethyleneimine can be used to modify the surface of iron oxide nanoparticles, but there are still problems of agglomeration, and it is not easy to preserve [Colliods Surf., B , 2014, 122, 752]. Researchers tried to prepare iron oxide nanoparticles by wet chemical method first, and then modified by polyethyleneimine...

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Problems solved by technology

It is an effective method to modify the surface of iron oxide nanoparticles. For example, polyethyleneimine can be used to modify the surface of iron oxide nanoparticles, but there are still problems of agglomeration, and it is not easy to preserve [Colliods Surf., B ,2014,122,752]

Researchers tried to prepare iron oxide nanoparticles by wet chemical method first, and then modified by polyethyleneimine polymer [J.Magn.Magn.Mater.,2015,375,217], but the obtained polyethyleneimine modified iron oxide nanoparticles Still have disadvantages such as uneven size

Some researchers tried to prepare polyethylene glycol-polyethyleneimine copolymer, and then modified it on the basis of preparing iron oxide nanoparticles by wet chemical method, but the problem of uniform size of nanoparticles has not been effectively improved[Transactions of Nonferrous Metals Society of China, 2008, 18, 393]

Park et al. used high temperature method to prepare iron oxide nanoparticles with uniform size [Nat Mater., 2004,3,891]. However, because the surface of the prepared iron oxide nanoparticles is hydrophobic molecules, it is difficult to easily water, which limits its application in medicine.

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