A kind of absorbable orthopedic implant magnesium alloy and preparation method thereof

A magnesium alloy and orthopedic technology, applied in the field of absorbable orthopedic implanted magnesium alloy and its preparation, can solve the problems of mismatching elastic modulus, reduce bone healing speed, affect human health, etc., and achieve improved strength and overall biological phase. Capacitive, achieve the effect of grain refinement

Active Publication Date: 2020-01-14
PEKING UNIV SHENZHEN GRADUATE SCHOOL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these metal biomaterials have the following disadvantages: first, the elastic modulus of the implanted device does not match the bone tissue, and a "stress shielding" effect occurs at the junction with the bone tissue after implantation, thereby inhibiting new bone growth and reducing bone tissue. Healing speed; second, as an inert metal, it will remain in the body as a foreign body for a long time after implantation, resulting in ion dissolution and affecting human health. Therefore, a second operation is required to remove it, which increases the pain of the patient
[0004] The study of magnesium alloy as an orthopedic implant material in animals has confirmed the feasibility of its application in absorbable orthopedic implant devices, but its mechanical properties, corrosion resistance and biocompatibility still need further research and improvement

Method used

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  • A kind of absorbable orthopedic implant magnesium alloy and preparation method thereof
  • A kind of absorbable orthopedic implant magnesium alloy and preparation method thereof
  • A kind of absorbable orthopedic implant magnesium alloy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]Absorbable orthopedic implant magnesium alloy, the composition is: 4.0wt% Zn, 1.2wt% Y, 0.8wt% Nd, 0.2wt% Sc, the balance is Mg, and unavoidable impurity elements.

[0037] 1. Preliminary preparation

[0038] The raw material of this embodiment is:

[0039] High-purity magnesium ingot (purity ≥ 99.9%): 2520g

[0040] High-purity zinc ingot (purity ≥ 99.9%): 144g, in which the content of Zn is 1.2 times that of the obtained magnesium alloy (target product);

[0041] Mg-25.0wt% Y master alloy: 158g, wherein the content of Y is 1.1 times that in the obtained magnesium alloy (target product);

[0042] Mg-25.0wt% Nd master alloy: 106g, wherein the content of Nd is 1.1 times of that in the obtained magnesium alloy (target product);

[0043] Mg-10.0wt% Sc master alloy: 72g, wherein the content of Sc is 1.2 times that in the obtained magnesium alloy (target product);

[0044] In order to avoid oxidation and combustion of the magnesium alloy, a protective gas has been passed ...

Embodiment 2

[0059] Absorbable orthopedic implant magnesium alloy, the composition is: 6.0wt% Zn, 1.2wt% Y, 0.8wt% Nd, 0.2wt% Sc, the balance is Mg, and unavoidable impurity elements.

[0060] 1. Preliminary preparation

[0061] The required raw materials of this embodiment are:

[0062] High-purity magnesium ingot (purity ≥ 99.9%): 1632g

[0063] High-purity zinc ingot (purity ≥ 99.9%): 144g, in which the content of Zn is 1.2 times that of the obtained magnesium alloy (target product);

[0064] Mg-25.0wt% Y master alloy: 106g, wherein the content of Y is 1.1 times that in the obtained magnesium alloy (target product);

[0065] Mg-25.0wt% Nd master alloy: 70g, wherein the content of Nd is 1.1 times of its in the obtained magnesium alloy (target product);

[0066] Mg-10.0wt% Sc master alloy: 48g, wherein the content of Sc is 1.2 times that of its obtained magnesium alloy (target product);

[0067] In order to avoid oxidation and combustion of the magnesium alloy, a protective gas has be...

Embodiment 3

[0082] Absorbable orthopedic implant magnesium alloy, the composition is: 8.0wt% Zn, 2.0wt% Y, 0.8wt% Nd, 0.4wt% Sc, the balance is Mg, and unavoidable impurity elements.

[0083] 1. Preliminary preparation

[0084] The required raw materials of this embodiment are:

[0085] High-purity magnesium ingot (purity ≥ 99.9%): 1466g

[0086] High-purity zinc ingot (purity ≥ 99.9%): 192g, in which the content of Zn is 1.2 times that of the obtained magnesium alloy (target product);

[0087] Mg-25.0wt% Y master alloy: 176g, wherein the content of Y is 1.1 times of its in the obtained magnesium alloy (target product);

[0088] Mg-25.0wt% Nd master alloy: 70g, wherein the content of Nd is 1.1 times of its in the obtained magnesium alloy (target product);

[0089] Mg-10.0wt% Sc master alloy: 96g, wherein the content of Sc is 1.2 times that in the obtained magnesium alloy (target product);

[0090] In order to avoid oxidation and combustion of the magnesium alloy, a protective gas has ...

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Abstract

The invention belongs to the field of biomedical materials and particularly relates to an absorbable orthopedic implanted magnesium alloy. The absorbable orthopedic implanted magnesium alloy comprises, by mass, 4.0-8.0% of Zn, 0.8-2.0% of Y, 0.6-2.0% of Nd, 0.2-0.4% of Sc, and the balance Mg. The invention further discloses a preparation method of the absorbable orthopedic implanted magnesium alloy. According to the method, the absorbable orthopedic implanted magnesium alloy is formed by melting magnesium ingots, zinc ingots, a Mg-Y intermediate alloy, a Mg-Nd intermediate alloy and a Mg-Sc intermediate alloy as furnace burden. High-content Zn is added to pure magnesium to serve as a main strengthening element; the high requirement for the strength of the orthopedic implanted material is achieved through solution strengthening and dispersion strengthening; a few rare earth elements Y, Nd and Sc are added compositely to improve the mechanical performance and the corrosion resistance ofthe alloy and achieve the purposes of structure and grain refinement. Through combination of multiple passes of extrusion processing at the big extrusion ratio and annealing heat treatment after extrusion, the superfine-grained magnesium alloy with second phases finely dispersed and distributed in a base body, and the mechanical performance and corrosion resistance of the absorbable orthopedic implanted magnesium alloy are greatly improved.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to an absorbable orthopedic implant magnesium alloy and a preparation method thereof. Background technique [0002] Bone tissue injuries caused by traffic accidents, sports trauma, etc. have a high incidence in people's daily life. During the treatment of bone tissue injuries, it is necessary to implant instruments to repair and fix bone tissues. Therefore, orthopedic implants Become the most important one in the medical device industry. At present, the orthopedic implant materials widely used clinically mainly include metal biomaterials such as stainless steel, titanium alloy, and cobalt alloy. However, these metal biomaterials have the following disadvantages: first, the elastic modulus of the implanted device does not match the bone tissue, and a "stress shielding" effect occurs at the junction with the bone tissue after implantation, thereby inhibiting new bone g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02
CPCA61L27/047C22C1/03C22C23/04C22F1/06
Inventor 都贝宁盛立远
Owner PEKING UNIV SHENZHEN GRADUATE SCHOOL
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