Preparation method and application of hollow mesoporous bioglass microspheres

A technology of bioglass and empty mesopores, applied in the direction of inorganic non-effective ingredients, can solve the problems of affecting bone formation speed, causing inflammatory reactions, small specific surface area, etc., achieving long drug release cycle, high drug loading, and simple process Effect

Inactive Publication Date: 2018-08-28
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional mesoporous bioglass materials are mostly irregular-shaped particles, which can easily cause inflammatory reactions in the human body and affect the speed of bone formation. At the same time, their small specific surface area and low drug loading limit their application.

Method used

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  • Preparation method and application of hollow mesoporous bioglass microspheres
  • Preparation method and application of hollow mesoporous bioglass microspheres
  • Preparation method and application of hollow mesoporous bioglass microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation method of the hollow mesoporous biological glass microspheres provided in this embodiment is as follows:

[0035] (1) Dissolve 0.1g of cetyltrimethylammonium bromide (CTAB) in 75mL of ethanol aqueous solution, wherein the volume ratio of alcohol / water is 0.1, stir for 5min, and the temperature is 20°C;

[0036] (2) Add 1 mL of ammonia water with a mass concentration of 37% into the system of step (1), and stir for 1 min;

[0037] (3) Add 1 mL of tetraethyl orthosilicate (TEOS) into the system of step (2), and stir for 10 min;

[0038] (4) Add 0.45g of calcium nitrate tetrahydrate (CN) into the system of step (3), and stir for 2h;

[0039] (5) Centrifuge the solution obtained in step (4), wash it 3 times with deionized water, then add it to 100mL deionized water, and mix well;

[0040] (6) Place the solution obtained in step (5) in a hydrothermal reaction kettle, and heat it at 50° C. for 24 hours;

[0041] (7) centrifuging the solution in step (6) to ...

Embodiment 2

[0045] The preparation method of the hollow mesoporous biological glass microspheres provided in this embodiment is as follows:

[0046] (1) Dissolve 0.50g of cetyltrimethylammonium bromide (CTAB) in 75mL of ethanol aqueous solution, wherein the volume ratio of alcohol / water is 0.5, stir for 15min, and the temperature is 60°C;

[0047] (2) Add 2 mL of ammonia water with a mass concentration of 37% into the system of step (1), and stir for 5 min;

[0048] (3) Add 2 mL of tetraethyl orthosilicate (TEOS) into the system of step (2), and stir for 30 min;

[0049] (4) Add 0.9g calcium nitrate tetrahydrate (CN) into the system of step (3), and stir for 8h;

[0050] (5) Centrifuge the solution obtained in step (4), wash it 3 times with deionized water, then add it to 200mL deionized water, and mix well;

[0051] (6) Place the solution obtained in step (5) in a hydrothermal reaction kettle, and heat it at 80° C. for 12 hours;

[0052] (7) The white solid obtained by centrifuging th...

Embodiment 3

[0056] The preparation method of the hollow mesoporous biological glass microspheres provided in this embodiment is as follows:

[0057] (1) Dissolve 0.50 g of cetyltrimethylammonium bromide (CTAB) in 150 mL of aqueous ethanol, wherein the alcohol / water volume ratio is 1, and stir for 15 min;

[0058] (2) Add 5 mL of ammonia water with a mass concentration of 37% into the system of step (1), and stir for 5 min;

[0059] (3) Add 12mL tetraethyl orthosilicate (TEOS) into the system of step (2), and stir for 20min;

[0060] (4) Add 4g of calcium nitrate tetrahydrate (CN) into the system of step (3), and stir for 24h;

[0061] (5) Centrifuge the solution obtained in step (4), wash it 3 times with deionized water, then add it to 500mL deionized water, and mix well;

[0062] (6) Place the solution obtained in step (5) in a hydrothermal reaction kettle, and heat it at 120°C for 24 hours;

[0063] (7) centrifuging the solution in step (6) to obtain a white solid, washing with water...

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Abstract

The invention discloses a preparation method and application of hollow mesoporous bioglass microspheres. The method comprises the steps that hexadecyl trimethyl ammonium bromide is used as a mesoporous template, in an ethanol aqueous solution, ammonium hydroxide is used as hydrolyst, tetraethyl orthosilicate is used as a silicon source, and calcium nitrate terahydrate is used as a calcium source;firstly, nanoscale bioglass microspheres are prepared, then, by using the strength difference of the surfaces of the mesoporous microspheres and internal silicon-oxygen bonds, through hydrothermal selectivity etching, hollow structures are obtained, a residual template agent is removed through high temperature, and finally the submicron-order hollow mesoporous bioglass microspheres are obtained. The preparation technology is simple, the cost is low, and the microspheres are easy to amplify and synthesize. The prepared microspheres of the hollow mesoporous structures have high specific surfacearea and pore volume, mesopores run through a shell layer, the average pore diameter is larger than 10 nm, and the cavity sizes of the microspheres can be adjusted and controlled through the hydrothermal temperature and time. When being used as medical carriers, the microspheres have high medicine carrying amount and a good slow-release effect.

Description

technical field [0001] The invention relates to the technical field of preparation of inorganic mesoporous materials and medical applications, in particular to a preparation method and application of hollow mesoporous biological glass microspheres. Background technique [0002] Mesoporous material is a new type of material with huge specific surface area and three-dimensional pore structure, and the pore size is between micropore and macropore. Since Mobil Corporation first reported the MCM series mesoporous silicon with high specific surface area and high degree of order in 1992, the synthesis of mesoporous materials with different shapes and their applications in the fields of separation, catalysis, chemical sensors, drug delivery, etc. received widespread attention. Hollow mesoporous materials have both mesoporous and macroporous structures, and possess the characteristics of both. The inner cavity of the macropore can greatly increase the loading capacity of the guest ...

Claims

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Application Information

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IPC IPC(8): C03C12/00C03C6/00A61K47/02
CPCA61K47/02C03C1/006C03C12/00
Inventor 赵娜如崔易航段海波王迎军
Owner SOUTH CHINA UNIV OF TECH
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