33results about How to "Narrow and uniform particle size distribution" patented technology

The invention discloses a preparation method of microporous ultrafine high activity nickel carbonate, comprising the following steps of adopting mixed acid solution prepared from nitric acid, sulfuric acid and hydrochloride to dissolve metal nickel to prepare composite nickel salts used as raw materials; carrying out precipitation reaction with the composite nickel salts by using mixed percipitant of sodium carbonate, ammonium carbonate or ammonium bicarbonate and sodium hydroxide in a sealed drum type reaction pot under the action of high pressure CO2; and preparing the nickel carbonate by crushing and drying precipitates by adopting an integrative machine of crushing and drying after washing the precipitates. Shown through a particle image analyzer, a full-automatic specific surface area voidage analyzer and an SEM (Scanning Electron Microscope) photograph result, the nickel carbonate has fine size, the particle size of D50 can achieve 1-5 microns, the particle size specific surface area can achieve more than 300m2 / g, the content of carbon dioxide is larger than 20 percent, the nickel carbonate has multiple and small micropores, the powder nickel carbonate with the nickel content of 49-51 percent has narrow and uniform particle size distribution, wherein the particle size of D10 is 0.93 microns, the particle size of D50 is 1.81 microns and the particle size of D90 is 2.82 microns, and the dispersion of the powder nickel carbonate is favorable.

The invention relates to the technical field of lithium ion batteries, and discloses a lithium ion battery cathode material and a preparation method and application thereof. The preparation method ofthe lithium ion battery cathode material comprises the following steps: hydrolyzing metal alkoxide to coat the surface of a nickel-cobalt binary precursor with a pseudo-boehmite layer to obtain a ternary precursor, wherein the chemical formula of the binary precursor is NixCoy (OH) 2, x and y are both greater than 0, and x + y = 1; and uniformly mixing the ternary precursor with a lithium salt, and sintering in an oxygen atmosphere to obtain LiNiaCobAlcO2, in which a, b and c are all greater than 0, and a + b + c = 1. The lithium ion battery cathode material is prepared by adopting the preparation method provided by the invention. The cathode material prepared by the preparation method provided by the invention has the characteristics of stable electrochemical performance, uniform chemicalcomponents, narrow and uniform particle size distribution and the like. The cathode material can be applied to preparation of a lithium ion battery cathode or a lithium ion battery.

The invention discloses an apramycin liposome. The apramycin liposome is a composition with a spherical or ellipsoidal double-film structure, and is formed by encapsulating apramycin with a liposome film. A preparation method comprises the following steps: 1) dissolving the apramycin and the liposome film with ethanol to obtain a mixed solution, and dissolving the mixed solution into supercritical CO2 to obtain a supercritical solution, wherein the mass ratio of the apramycin to the liposome film is (1 : 1) to (1 : 30); the liposome film is phosphatidylcholine, or a mixture of phosphatidylcholine and cholesterol; 2) dissolving a stabilizer into an aqueous medium to obtain a stabilizer solution; 3) spraying the supercritical solution to the stabilizer solution at an expansion pressure of 15-30MPa and a pre-expansion temperature of 323-343K, dispersing and precipitating to obtain an apramycin liposome suspension.

The invention discloses a clean production method for high-purity cobaltosic oxide powder. The method comprises the following steps: using metal cobalt as an electrolytic anode, using soluble cobalt salt as electrolyte main salt and adding additives; adopting an electrochemical method to prepare a cobaltosic oxide precursor sediment; and then, drying and calcining the precursor sediment to obtainthe cobaltosic oxide powder. The cobaltosic oxide powder produced by the method and the process can achieve the purity more than 99.7 percent, no additional precipitator is needed in the whole technological process, the added additives are all easy to wash without decomposition, and electrolyte and washing water can be recycled so as to avoid discharging sewage and generating waste gas. The method can adjust and control the appearance and the grain diameter distribution of the cobaltosic oxide powder by controlling the composition of the electrolyte, the cathode current concentration, the electrodeposition time and the calcining temperature and has the advantages of high product quality, simple production procedures, energy saving, environmental protection, and the like.

The invention provides glycosyl polyether compound lipidosome as well as a preparation method and a medicine thereof. The glycosyl polyether compound lipidosome comprises a glycosyl polyether compound and a lipidosome, and the lipidosome wraps the glycosyl polyether compound to form a double-layer membrane. The preparation method comprises the following steps: dissolving lipidosome and a glycosyl polyether compound by using an organic solvent; and carrying out suspended evaporation to remove the organic solvent, mixing with a water-phase medium, and carrying out ultrasonic treatment. The provided medicine comprises the glycosyl polyether compound liposome. The glycosyl polyether compound lipidosome provided by the invention is small in particle size and narrow and uniform in particle size distribution, fully ensures the physiological efficacy of the glycosyl polyether compound, and is simple in preparation method.

Disclosed are a processing modifier for a polyvinyl chloride pipe and pipe fitting and a polyvinyl chloride resin composition using the processing aid. The processing modifier for a polyvinyl chloride pipe and pipe fitting uses a two-stage emulsion polymerization process; the emulsion polymerization uses sodium dodecyl diphenyl ether disulfonate; the first stage monomer composition accounts for 50 wt% of the total monomers; the second stage monomer composition accounts for 50 wt% of the total monomers; the second-stage monomer composition uses a pre-emulsification dropwise addition method: the polymerization temperature is controlled at 55-75°C to prepare a copolymerization emulsion; the emulsion is then spray-dried to prepare a solid powder product; wherein based on the total weight of the first and second stage monomer compositions as 100%, the styrene is 70-85%; the acrylonitrile is 10-20%; the n-butyl methacrylate is 0-10%; and the polymer produced can significantly improve the hardness and thermal resistant stability of a processing modifier for a polyvinyl chloride pipe and pipe fitting.

The invention discloses a method for preparing nanoliposomes by supercritical CO2 fluid, which comprises the following steps of: (1) dissolving a certain amount of lipid membrane materials and cosurfactant into supercritical CO2 in a supercritical reaction kettle, and solubilizing a certain amount of distilled water to form a supercritical micro-emulsion; (2) pre-expanding the supercritical micro-emulsion under set pressure and temperature and then rapidly jetting into a water phase medium in a supercritical collection kettle through a nozzle at a certain flow velocity, and dispersing and settling out to form liposome mixed suspension liquid; and (3) continuously dissolving CO2 through the supercritical collection kettle and removing residual ethanol in the liposome mixed suspension liquid, metering by a rotor metering gauge and evacuating, and collecting the liposome mixed suspension liquid in the supercritical collection kettle. In the technology, the micro-emulsion of the lipid membrane materials formed in the supercritical CO2 is used as a template for assembling the lipid, and the lipid is collected by using the supercritical rapid expansion technology so as to provide a new path for preparing the nanoliposomes.

The invention relates to a styrene-acrylic composite emulsion, particularly preparation of silicon-containing styrene-acrylic composite emulsion nanoparticles, which comprises the following steps: 1. pre-emulsification: adding an emulsifier and a seed monomer to carry out pre-emulsification; 2. adding an initiator to carry out seed emulsion polymerization; and 3. adding the rest of monomer, emulsifier, initiator and silane coupling agent into the polymerization system to carry out polymerization, thereby obtaining the silicon-containing nano polyacrylate composite emulsion. The whole preparation process has a definite procedure and is simple to operate. By adopting free radical copolymerization, the silicon-containing acrylates are introduced into the styrene-acrylic polymer emulsion by copolymerization, thereby preparing the monodisperse nano silicon-containing styrene-acrylic emulsion. The product integrates the advantages of silicon and nano styrene-acrylic emulsion. The monodisperse styrene-acrylic composite emulsion has small-size effect, surface effect, quantum size effect, macroscopic tunneling effect and the like. Therefore, related materials have electric, magnetic, thermal and optical sensitivity, and the surface stability is obviously different from that of micron particles. The invention relates to the application fields of chemistry, materials, biology, medicine, textile, paper making and the like, and has high use value.

The invention relates to the field of pharmaceutical preparations, and provides a self-microemulsion of amygdaloside, a dosage form prepared by the self-microemulsion and a preparation method thereof.The self-microemulsion of amygdaloside comprises amygdaloside, oil phase, emulsifier and co-emulsifier, wherein the weight ratio of oil phase, emulsifier and co-emulsifier is (20-75): (25-60): (0.1-30). The self-microemulsion has the advantages of high drug loading, stable quality, narrow and uniform particle size distribution, greatly improves the membrane permeability of the drug, enables the drug to reach the lesion finally, has better therapeutic effect, and has a wide application prospect. The self-microemulsion has the advantages of high drug loading, stable quality, narrow and uniformparticle size distribution, and greatly improves the membrane permeability of the drug.

The invention relates to a preparation method of a surface-modified colloidal state silicon nanocrystal. The preparation method comprises the following steps that (1) a mixed liquid of nanometer silicon powder and an organic solvent is subjected to laser cauterization treatment under the stirring state; (2) the mixed liquid after laser cauterization treatment is subjected to separation treatment, and the colloidal state silicon nanocrystal is obtained. The particle size distribution range of the colloidal state silicon nanocrystal prepared with the preparation method is controllable, the dispersity is good, no agglomeration occurs, and oxidation can be avoided.

The invention discloses an apramycin liposome. The apramycin liposome is a composition with a spherical or ellipsoidal double-film structure, and is formed by encapsulating apramycin with a liposome film. A preparation method comprises the following steps: 1) dissolving the apramycin and the liposome film with ethanol to obtain a mixed solution, and dissolving the mixed solution into supercritical CO2 to obtain a supercritical solution, wherein the mass ratio of the apramycin to the liposome film is (1 : 1) to (1 : 30); the liposome film is phosphatidylcholine, or a mixture of phosphatidylcholine and cholesterol; 2) dissolving a stabilizer into an aqueous medium to obtain a stabilizer solution; 3) spraying the supercritical solution to the stabilizer solution at an expansion pressure of 15-30MPa and a pre-expansion temperature of 323-343K, dispersing and precipitating to obtain an apramycin liposome suspension.

The invention discloses a method for preparing high-purity antimony trioxide, and relates to the technical field of antimony trioxide preparation. The preparation method of a high-purity antimony trioxide disclosed by the present invention is as follows: adding crude antimony ore to hydrochloric acid for immersion, feeding chlorine gas, adding iron powder to the obtained antimony chloride mixed solution, and reacting to obtain an antimony chloride solution; Then add an appropriate amount of 4mol / L sodium hydroxide solution, the pH value is 8-9, stir and filter, wash, dry, and roast in the air atmosphere to obtain antimony trioxide; Air and composite lead remover, the obtained antimony trioxide powder is vaporized and then quenched to obtain high-purity antimony trioxide. The method provided by the invention is simple to prepare, uses less composite lead remover, lower cost, can be recycled and used without burdening the environment, and the purity of the prepared antimony trioxide can reach up to 99.5%, and the particle size can reach Nanoscale, uniform particle size distribution.

The invention discloses an atractylone lipidosome containing atractylone and a lipidosome membrane material, wherein the atractylone is an Atractylis ovata extract, and the lipidosome membrane material is phosphatidylcholine or cholesterol. A method for preparing the atractylone lipidosome by adopting a supercritical fluid dispersing precipitation technology comprises the following steps of: (1) dissolving the atractylone and the lipidosome membrane material in a supercritical CO2 / alcohol mixed solvent, then obtaining a supercritical solution; (2) dissolving a surface active agent as a stabilizer in an aqueous medium, then obtaining a stabilizer solution; (3) and rapidly jetting the supercritical solution to the stabilizer solution at a certain pre-swelling pressure and pre-swelling temperature, and then obtaining an atractylone lipidosome mixed suspension by forcible dispersion and precipitation. The preparation process of the lipidosome is completed in the chemically inert CO2 medium; toxic organic solvents are not used, and the envelop rate of the lipidosome is improved, thereby effectively avoiding the agglomeration phenomenon caused by colliding among lipidosome particles, and ensuring the stability of the atractylone lipidosome in the preparation process.