High-strength dual-responsiveness nano-composite double network hydrogel and preparation method thereof

Abstract

The invention relates to high-strength dual-responsiveness nano-composite double network hydrogel and a preparation method thereof. The hydrogel is PNIPAM / clay / GP / CMCTs; a rigid first layer network isprepared by adopting a biocrosslinking agent GP crosslinked CMCTs and a flexible second layer network is prepared by adopting a physical crosslinker clay crosslinked PNIPAM molecular chain. The preparation method comprises the following steps: adding clay into deionized water; then successively adding NIPAM, a photoinitiator, a GP aqueous solution and CMCTs to obtain dispersion liquid; transferring the dispersion liquid into a mould; vacuumizing, introducing nitrogen, then sealing and carrying out water bath reaction at room temperature; then carrying out ultraviolet irradiation, thus obtaining a finished product. The preparation process disclosed by the invention has the advantages of simplicity, easiness in operation and facilitation for industrialized production; the prepared hydrogelhas the characteristics of high mechanical strength, good biocompatibility and temperature / pH double corresponding property; the high-strength dual-responsiveness nano-composite double network hydrogel has a better development prospect in the fields of drug release and molecular devices such as chemical valves.

Description

technical field

[0001] The invention belongs to the technical field of polymer materials, and in particular relates to a high-strength double-response nanocomposite double-network hydrogel and a preparation method thereof. Background technique

[0002] Hydrogels are made of cross-linked hydrophilic polymers that absorb water and swell. According to the different responses of hydrogels to external stimuli, they can be divided into two categories: traditional hydrogels and stimuli-responsive hydrogels. Among them, the stimuli-responsive hydrogel can change the size of its own volume with small changes in the outside world (temperature, pH, light, electric field, magnetic field, etc.). Due to the good biomimetic properties and biocompatibility of stimuli-responsive hydrogels, they are widely used in tissue engineering, drug release, chemical valves, biosensors and other fields.

[0003] The main component of synthetic clay is lithium magnesium silicate, which has good water s...

Examples

Embodiment 1

[0037] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 3mg carboxymethyl chitosan CMCTs, continue to stir with 300rpm rotating speed for 2h, mix well, obtain NIPAM / clay / GP / CMCTs dispersion liquid; Transfer to the transparent plastic tube mold that diameter is 4.65mm, length is 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP crosslinked CMCTs.

[0038](2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-r...

Embodiment 2

[0040] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 9mg carboxymethyl chitosan CMCTs, continue to stir at 300rpm for 2h, mix well to obtain NIPAM / clay / GP / CMCTs dispersion; transfer to a transparent plastic tube mold with a diameter of 4.65mm and a length of 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP cross-linked CMCTs.

[0041] (2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-responsive nanoc...

Embodiment 3

[0043] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 15mg carboxymethyl chitosan CMCTs, continue to stir at 300rpm for 2h, mix well to obtain NIPAM / clay / GP / CMCTs dispersion; transfer to a transparent plastic tube mold with a diameter of 4.65mm and a length of 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP cross-linked CMCTs.

[0044] (2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-responsive nano...

technical field

[0001] The invention belongs to the technical field of polymer materials, and in particular relates to a high-strength double-response nanocomposite double-network hydrogel and a preparation method thereof. Background technique

[0002] Hydrogels are made of cross-linked hydrophilic polymers that absorb water and swell. According to the different responses of hydrogels to external stimuli, they can be divided into two categories: traditional hydrogels and stimuli-responsive hydrogels. Among them, the stimuli-responsive hydrogel can change the size of its own volume with small changes in the outside world (temperature, pH, light, electric field, magnetic field, etc.). Due to the good biomimetic properties and biocompatibility of stimuli-responsive hydrogels, they are widely used in tissue engineering, drug release, chemical valves, biosensors and other fields.

[0003] The main component of synthetic clay is lithium magnesium silicate, which has good water s...

Examples

Embodiment 1

[0037] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 3mg carboxymethyl chitosan CMCTs, continue to stir with 300rpm rotating speed for 2h, mix well, obtain NIPAM / clay / GP / CMCTs dispersion liquid; Transfer to the transparent plastic tube mold that diameter is 4.65mm, length is 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP crosslinked CMCTs.

[0038](2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-r...

Embodiment 2

[0040] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 9mg carboxymethyl chitosan CMCTs, continue to stir at 300rpm for 2h, mix well to obtain NIPAM / clay / GP / CMCTs dispersion; transfer to a transparent plastic tube mold with a diameter of 4.65mm and a length of 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP cross-linked CMCTs.

[0041] (2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-responsive nanoc...

Embodiment 3

[0043] (1) Add 0.04g clay clay to 2.7mL deionized water, stir at 300rpm for 4h, dissolve evenly, then add 0.3g recrystallized NIPAM, 2.5mg photoinitiator 2959, 300μL genipin GP aqueous solution (1.5 mg / ml) and 15mg carboxymethyl chitosan CMCTs, continue to stir at 300rpm for 2h, mix well to obtain NIPAM / clay / GP / CMCTs dispersion; transfer to a transparent plastic tube mold with a diameter of 4.65mm and a length of 60mm , and then use a power of 180W to put in a circulating water vacuum pump for 10min and fill it with high-purity nitrogen, repeat 3 times, then seal the other end of the plastic tube, and react in a water bath at room temperature for 20h to obtain a hydrogel of GP cross-linked CMCTs.

[0044] (2) irradiate the hydrogel obtained in step (1) with a wavelength of 365nm and a power of 8W in a water bath at room temperature for 2h, rotate the sample by 90 degrees every 0.5h, and the distance from the lamp tube to the sample is 10mm, A high-strength dual-responsive nano...

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