A supramolecular hydrogel and its preparation method, and a slow-release preparation for killing schistosome cercariae and its preparation method
A technology of supramolecular hydrogel and sustained-release preparations, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, and can solve problems such as poor water solubility, difficulty in extraction, and short duration of drug action and other problems, to achieve the effects of good mechanical properties, strong hydrogen bonding, good drug loading and sustained release performance
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[0037] The present invention provides a preparation method of the supramolecular hydrogel described in the above technical scheme, comprising the following steps:
[0038] The supramolecular hydrogel is obtained by mixing N,N'-diaspartic acid-perylenetetracarboxylic acid diimide, water and tetrahydrofuran, and then performing ultrasonic treatment.
[0039] In the present invention, the power of the ultrasonic treatment is preferably 300-600W, more preferably 400-500W; the time is preferably 2.5-3.5h, more preferably 3h. In an embodiment of the present invention, specifically, N,N'-diaspartic acid-perylenetetracarboxylic acid diimide, water and tetrahydrofuran are mixed and then ultrasonicated until the resulting system is gelled to obtain a supramolecular hydrogel.
[0040] In the present invention, NAAPD is an amphiphilic molecule with a hydrophobic structure in the middle and hydrophilic groups at both ends. Ultrasound provides energy for the NAAPD molecule, so that the NAAP...
Embodiment 1
[0048] Mix 0.01mmol of N,N'-diaspartic acid-perylenetetracarboxylic acid diimide with 1mL of water and 1mL of tetrahydrofuran, and ultrasonically treat it for 3h under the condition of 400W, until the obtained system is gelled, and a deep red N,N '-Diaspartic acid-perylenetetracarboxylic acid diimide (NAAPD) gel.
[0049] Characterize the morphology and structure of the NAAPD gel, and test its mechanical properties, specifically as follows:
[0050] (1) The NAAPD gel is mixed with water to prepare 10 -4 mol / L hydrogel solution, the hydrogel solution was dropped on the surface of the silicon wafer stuck on the conductive adhesive, and dried naturally, and the morphology of the obtained xerogel was characterized by using a FEIQUANTA450 scanning electron microscope, and the accelerated voltage 15.0kV. figure 1 It is the SEM image of the NAAPD gel, wherein (a) is the SEM image of the NAAPD gel in a large range, and (b) is the SEM image of the NAAPD gel in a small range. Depend ...
Embodiment 2
[0053] Mix 0.01mmol of N,N'-diaspartic acid-perylenetetracarboxylic acid diimide with 0.5mL of water, 0.5mL of tetrahydrofuran and polyether benzamide, and ultrasonically treat it at 400W for 3h until the resulting system gels , to obtain NAAPD gel loaded with polyether benzamide (drug-loaded NAAPD gel).
[0054] By changing the amount of polyether benzamide added, the drug-loading ability of NAAPD gel was tested by the classic test tube inversion method. The experimental results show that under the condition that a stable gel state can be formed (such as Figure 5 Shown in a), the maximum drug loading capacity of NAAPD gel is 500mg / mL.
[0055] According to the method in Example 1, the morphology of the drug-loaded NAAPD gel (drug loading is 100mg / mL) is characterized, and its mechanical properties are tested, as follows:
[0056] (1) if Figure 5 As shown in b and 5c, (b) is the SEM image of the drug-loaded NAAPD gel in a large range, and (c) is the SEM image of the drug-...
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