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A kind of preparation method of Huzhen gout nanoparticle

A nanoparticle, Huzhengout technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas and other directions, can solve the problems of poor stability, change and disappearance of nanometer powder

Active Publication Date: 2021-04-20
GUANGDONG ROC MEDICINAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, the above-mentioned nanotechnology increases the surface area of ​​natural plants, which causes an increase in free energy. Since the free energy tends to be the smallest, the nano-powder has a tendency to re-agglomerate, resulting in poor stability of the nano-powder.
Moreover, the composition of traditional Chinese medicine is very complex. Nano-Chinese medicine will lead to changes in the physical and chemical properties, biological activities, efficacy, and side effects of single herbs or compound prescriptions. When the particle size enters the nanometer level, due to quantum size effects and surface effects, it may cause major changes
The function of the drug in the nano state may be enhanced, weakened, or disappeared, and new effects may appear; and the toxic and side effects of the drug may also change accordingly

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Embodiment 1, the preparation of a kind of Huzhen gout nanoparticle

[0035] S1 put 6 parts by weight of Polygonum cuspidatum, 5 parts by weight of plantain, 5 parts by weight of Ligustrum lucidum and 2 parts by weight of honeycomb four kinds of raw medicinal materials into clean water and wash;

[0036] S2 drys the raw medicinal material washed in step S1, slices, and pulverizes to 500 mesh to obtain coarse powder I;

[0037] S3 dissolving ethyl cellulose in absolute ethanol to make an ethyl cellulose solution with a volume concentration of 2%, then adding it to the coarse powder I obtained in step S2, and stirring evenly to obtain an organic phase;

[0038]S4 mixes sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin to obtain a mixture A, and in the mixture A, sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin are mixed according to The weight ratio is 4:3, the mixture A is added into water and stirred evenly, the amount of water added is twi...

Embodiment 2

[0041] Embodiment 2, the preparation of a kind of Huzhen gout nanoparticle

[0042] S1 put 8 parts by weight of Polygonum cuspidatum, 6 parts by weight of plantain, 6 parts by weight of Ligustrum lucidum and 3 parts by weight of honeycomb into clean water for washing;

[0043] S2 drys the original medicinal material washed in step S1, slices, and pulverizes to 600 meshes to obtain coarse powder I;

[0044] S3 dissolving ethyl cellulose in absolute ethanol to make an ethyl cellulose solution with a volume concentration of 3%, then adding it to the coarse powder I obtained in step S2, and stirring evenly to obtain an organic phase;

[0045] S4 mixes sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin to obtain a mixture A, and in the mixture A, sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin are mixed according to The weight ratio is 5:2, the mixture A is added into water and stirred evenly, the amount of water added is 3 times of the weight of the m...

Embodiment 3

[0048] Embodiment 3, the preparation of a kind of Huzhen gout nanoparticle

[0049] S1 put 10 parts by weight of Polygonum cuspidatum, 8 parts by weight of plantain, 8 parts by weight of Ligustrum lucidum and 4 parts by weight of honeycomb into clean water for washing;

[0050] S2 drys the raw medicinal material washed in step S1, slices, and pulverizes to 800 mesh to obtain coarse powder I;

[0051] S3 dissolving ethyl cellulose in absolute ethanol to make an ethyl cellulose solution with a volume concentration of 4%, then adding it to the coarse powder I obtained in step S2, and stirring evenly to obtain an organic phase;

[0052] S4 mixes sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin to obtain a mixture A, and in the mixture A, sodium dodecylbenzenesulfonate and hydroxypropyl-β-cyclodextrin are mixed according to The weight ratio is 6:1, the mixture A is added into water and stirred evenly, the amount of water added is 4 times of the weight of the mixture...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Huzhen gout nano particles. The preparation method of the Huzhen gout nanoparticle agent provided by the invention is to first pulverize raw materials such as Polygonum cuspidatum, Plantain, Ligustrum lucidum and honeycomb, add ethyl cellulose solution to make an organic phase, and then add dodecylbenzenesulfonate Sodium phosphate and hydroxypropyl-β-cyclodextrin are mixed to form an aqueous phase, and the organic phase and the aqueous phase are mixed for ultrasonic treatment, centrifuged, resuspended, dried, and obtained. The preparation method of the Huzhen gout nano-particles provided by the present invention can directly release the active ingredients of the drug in the cells and between the cells, and improve the efficacy of the medicine; at the same time, the Huzhen gout nanoparticles have high adhesion to the intestinal wall , thereby improving the dissolution rate of active ingredients in the drug. In addition, the Huzhen gout nanoparticle agent also has the advantages of good fluidity, not easy to aggregate, low impurities and high stability, which is beneficial to the popularization and application of the Huzhen gout nanoparticle agent.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a preparation method of Huzhen gout nano particles. Background technique [0002] Gout is a group of diseases caused by hereditary or acquired causes of purine metabolism disorders or decreased uric acid excretion. It is caused by the precipitation of sodium urate or uric acid crystals from supersaturated extracellular fluid in tissues. There are one or more lesions clinical syndrome. With the improvement of living standard and the change of diet structure, the complication rate of gout presents a rising trend. Among them, acute gouty arthritis is the most common first symptom in gout, and it is also the most basic type of gout. The pain of acute gouty arthritis is in the nature of cutting and biting. At the same time, symptoms such as redness, swelling, heat, and pain appear in the joints and surrounding tissues, which seriously affect people'...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/704A61K47/40A61K47/20A61P19/06A61K35/64
CPCA61P19/06A61K9/1617A61K9/1652A61K35/63A61K36/638A61K36/68A61K36/704A61K2236/331A61K2236/15A61K2236/51A61K2300/00
Inventor 曹薇王一飞廖晓凤马婧
Owner GUANGDONG ROC MEDICINAL TECH CO LTD
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