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A kind of bioactive composite material and its preparation method and application

A composite material and bioactive technology, applied in the field of bioactive composite materials and their preparation, can solve the problems of weak interaction between BG and PDC, insufficient biological activity, low mechanical properties, etc., achieve good application prospects, improve the biological phase. Capacitive, highly bioactive effect

Active Publication Date: 2020-03-17
华魁科技泰州有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the BG content in the PDC / BG composites developed in recent years is low (BG content ≤ 30wt.%) and the interaction between BG and PDC is not strong, and the resulting composites still exhibit strong elastomeric properties and low mechanical properties. And the biological activity is not good enough, so it is not suitable for the repair of bone tissue defects

Method used

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  • A kind of bioactive composite material and its preparation method and application
  • A kind of bioactive composite material and its preparation method and application
  • A kind of bioactive composite material and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] (1) Preparation of PDC prepolymer

[0041] Add citric acid and 1,8-octanediol in a molar ratio of 1:0.8, with a total mass of 16.1g, into a 250ml round-bottomed flask, stir and dissolve in an oil bath at 160°C in a nitrogen atmosphere, and wait until completely dissolved , the temperature was lowered to 140° C., and the reaction was continued for 30 minutes to obtain a PDC prepolymer.

[0042] (2) Preparation of PDC-Si prepolymer

[0043] The PDC prepolymer obtained in step (1) was added to an ethanol solution containing 6.15 g of KH560 (the molar ratio of citric acid and KH560 was 1:0.5) for reaction to obtain a PDC-Si prepolymer.

[0044] (3) Preparation of citric acid-based bioactive composite materials modified by silane coupling agent

[0045] The PDC-Si prepolymer obtained in step (2) and bioactive glass particles (70% SiO 2 -30% CaO (mol.%)) is mixed according to the weight ratio of 40:60, after stirring evenly, carry out thermosetting molding at 50 ℃, obtain ...

Embodiment 2

[0048] (1) Preparation of PDC prepolymer

[0049] Add citric acid and 1,8-octanediol in a molar ratio of 1:1, with a total mass of 17.6g, into a 250ml round-bottomed flask, stir and dissolve in an oil bath at 160°C in a nitrogen atmosphere, and wait until completely dissolved Afterwards, the temperature was lowered to 140° C., and the reaction was continued for 30 minutes to obtain a PDC prepolymer.

[0050] (2) Preparation of PDC-Si prepolymer

[0051] The PDC prepolymer that step (1) obtains is joined in the ethanol solution that contains 6.15g KH560 (citric acid and KH560 molar ratio are 1:0.5) carry out reaction, obtain PDC-Si prepolymer (see figure 2 ).

[0052] (3) Preparation of citric acid-based bioactive composite materials modified by silane coupling agent

[0053] The PDC-Si prepolymer obtained in step (2) and bioactive glass particles (54.2% SiO 2 -35%CaO-10.8%P 2 o 5 (mol.%)) were mixed according to the weight ratio of 50:50, stirred evenly, and then therma...

Embodiment 3

[0056] (1) With step (1) in embodiment 2.

[0057] (2) Add the PDC prepolymer obtained in step (1) to the same volume of ethanol as in Example 2 (which does not contain KH560, so that the molar ratio of citric acid and KH560 is 1:0) to obtain a PDC prepolymer.

[0058] (3) Preparation of citric acid-based bioactive composites

[0059] The PDC prepolymer obtained in step (2) and bioactive glass particles (54.2% SiO 2 -35%CaO-10.8%P 2 o 5 (mol.%)) were mixed according to the weight ratio of 50:50, and after stirring evenly, thermosetting molding was performed at 80°C to obtain a citric acid-based bioactive composite material.

[0060] The compressive strength of the composite material measured by the universal material testing machine is 24±3MPa, and the compressive modulus is 160±27MPa (see image 3 The molar ratio of citric acid and KH560 is 1:0 group), the mechanical properties of the composite material are obviously lower than the composite material prepared in Example 1...

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Abstract

The invention relates to a bioactive composite material as well as a preparation method and application thereof. According to the bioactive composite material, poly-citrate glycol ester is compoundedwith bioactive glass, or the poly-citrate glycol ester is further modified with a saline coupling agent, then good bioactivity, osteoconduction, biocompatibility and controllable biodegradability canbe achieved, meanwhile mechanical properties can be relatively improved, and in addition, the preparation method is simple in process and easy in production.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to a bioactive composite material and its preparation method and application. Background technique [0002] With the increasing aging trend of the population, the incidence of bone defects caused by trauma, disease, aging, bone tumors, etc. is increasing year by year, which has become one of the main problems facing human health. The clinically used bone defect repair and replacement materials mainly include autologous bone, allogeneic bone and synthetic bone repair materials. Autologous bone is the most ideal material for bone repair, but the source of autologous bone is limited, and patients need to undergo secondary surgery to increase the pain of patients; allogeneic bone has problems such as disease transmission and immune rejection. Therefore, there is an increasing demand for synthetic bone repair and replacement materials. [0003] In recent years,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/695
CPCA61L27/46A61L27/50A61L27/54A61L27/58A61L2300/412C08G63/12C08G63/914C08K3/40C08L67/04
Inventor 邱东任辉辉张忠民赵慧宇李爱玲
Owner 华魁科技泰州有限公司
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