Stereoscanning mesoscopic photoacoustic imaging system for subcutaneous tumor of small animal

Abstract

The invention relates to a stereoscanning mesoscopic photoacoustic imaging system for a subcutaneous tumor of a small animal. The system comprises a light source system, a multi-angle stereo-scanningsystem, a water tank, a photoacoustic detection system, a data acquisition system and an industrial controller. The light source system comprises a high-energy pulse laser producing a photoacoustic signal and a multi-arm fiber optics bundle guiding emitted light of the laser. The photoacoustic detection system comprises a high-frequency point focused ultrasound detector used for receiving a photoacoustic signal, wherein defocusing-type measurement of the high-frequency point focused ultrasound detector is utilized. The multi-angle stereo-scanning system comprises an imaging support used for placing an imaging target, an electrically-controlled elevating table, an electrically-connected translational table and an electrically-controlled rotary table equipped with the high-frequency point focused ultrasound detector. The electrically-controlled rotary table is fixed onto the electrically-connected translational table. The imaging support is fixed onto the electrically-controlled elevating table. Through the electrically-controlled rotary table and the electrically-connected translational table, stereoscanning operation on a three-dimensional space is conducted by the high-frequency point focused ultrasound detector.

Description

technical field [0001] The invention belongs to the application field of near-infrared optical imaging technology in the direction of biomedicine, relates to a mesoscopic scale measurement method, in particular to a stereoscopic scanning photoacoustic mesoscopic imaging system for small animal subcutaneous tumors. Background technique [0002] According to the latest statistics from the National Cancer Registry Center, the morbidity and mortality of cancer are increasing year by year. Since 2010, cancer has officially become the leading cause of death and one of the important public health problems in China [1]. Tumor cell pathways are characterized by complexity and diversity, and a more comprehensive understanding of tumor angiogenesis status and drug targeting effects in a suitable in vivo model will help improve the level of clinical treatment. Therefore, the development of a high-resolution, high-contrast medical imaging technology is aimed at biomedical imaging resear...

AI Technical Summary

Problems solved by technology

Although the former has high detection sensitivity, the raster scanning method used is usually a two-dimensional planar type, which lacks omnidirectionality in the acquisition of photoacoustic signals in three-dimensional space; the latter can obtain three-dimensional and omnidirectional measurement data, but The measurement signal-to-noise ratio has a certain degree of decline

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