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Method for preparing rosemary acid

A technology for extracting rosmarinic acid, which is applied to the preparation of carboxylic acid esters, chemical instruments and methods, and the preparation of organic compounds, can solve the problems of high risk, low extraction rate of rosmarinic acid, and cumbersome steps, and achieve Huge social and economic value, low production cost, good separation effect

Active Publication Date: 2018-09-21
HUNAN XINLI BIOLOGICAL SCI & TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The defect of this method is: 1. the steps are loaded down with trivial details, and energy consumption is bigger; 2. ethyl acetate boiling point is low, and peculiar smell is big, volatilizes fast and inflammable and explosive at normal temperature, and danger is big, and environmental pollution is serious; 3. ethyl acetate and n-butyl The extraction rate of alcohol to rosmarinic acid is low, and the single extraction rate is only 22% and 41% respectively
The steps of this method are cumbersome, the column is passed many times, and the energy consumption is high. The extraction step only increases the purity by 2 times. The regeneration of the silica gel column requires high temperature treatment, which consumes a lot of energy and causes heavy pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A method for preparing rosmarinic acid, its concrete processing steps are as follows:

[0028] (1) Preparation of N503 extract

[0029] Mix the N503 extractant and sulfonated kerosene uniformly at a volume ratio of 1:1 L / L to prepare the N503 extract, which is used in step (3) to prepare the rosmarinic acid extract phase.

[0030] (2) preparation of rosmarinic acid stock solution

[0031] According to the method described in the Chinese Patent Example 1 of CN 107739305 A, the notification number is prepared to obtain the centrifuge liquid described in the (2) step, which is the waste liquid produced in the process of producing rosemary fat-soluble antioxidants. The volume ratio of the centrifugal supernatant and purified water is 1:1 L / L, and the centrifugal supernatant and purified water are evenly mixed, then pumped into a tubular centrifuge, and centrifuged at a speed of 10000r / min. Collect the second centrifugal supernatant and the second centrifugal slag respective...

Embodiment 2

[0043] A method for preparing rosmarinic acid, its concrete processing steps are as follows:

[0044] (1) Preparation of N503 extract

[0045] Mix the N503 extractant and sulfonated kerosene uniformly at a volume ratio of 1:3 L / L to prepare the N503 extract, which is used in step (3) to prepare the rosmarinic acid extract phase.

[0046] (2) preparation of rosmarinic acid stock solution

[0047] According to the method described in the Chinese Patent Example 1 of CN 107739305 A, the notification number is prepared to obtain the centrifuge liquid described in the (2) step, which is the waste liquid produced in the process of producing rosemary fat-soluble antioxidants. The volume ratio of the centrifugal supernatant and purified water is 1:3 L / L, and the centrifugal supernatant and purified water are evenly mixed, then pumped into a tubular centrifuge, and centrifuged at a speed of 15000r / min. Collect the second centrifugal supernatant and the second centrifugal slag respecti...

Embodiment 3

[0059] A method for preparing rosmarinic acid, its concrete processing steps are as follows:

[0060] (1) Preparation of N503 extract

[0061] Mix the N503 extractant and sulfonated kerosene uniformly at a volume ratio of 1:5 L / L to prepare the N503 extract, which is used in step (3) to prepare the rosmarinic acid extract phase.

[0062] (2) preparation of rosmarinic acid stock solution

[0063] According to the method described in Chinese Patent Example 1 with the notification number CN 107739305A, the centrifugal supernatant liquid described in the (2) step is prepared, which is the waste liquid produced in the process of producing rosemary fat-soluble antioxidants. The volume ratio of the supernatant to the purified water is 1:5 L / L, and the centrifuged supernatant and the purified water are evenly mixed, then pumped into a tubular centrifuge, and centrifuged at a speed of 20,000 r / min. Collect the second centrifugal supernatant and the second centrifugal slag respectivel...

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Abstract

The invention discloses a method for preparing rosemary acid and belongs to the technical field of plant extraction. The method includes: taking waste liquor produced by the process of producing rosemary lipid soluble antioxidants as raw material; preparing a rosemary acid feed solution, rosemary acid extraction phase, rosemary acid reextraction phase, rosemary acid film concentrate, rosemary acidpowder and purified extract by preparing N503 extract liquor to obtain rosemary acid powder containing more than 65-80% o f rosemary acid. The obtained rosemary acid powder is high in rosemary acid,good in separation effect and high in yield; the N503 extract liquor can be reused after purified, no pollution is caused to environment, and typical green production technology is achieved; standardequipment conforming to GMP (good manufacturing practice) specification is used, standard operation, moderate condition and low production cost are achieved, and the prepared rosemary acid powder is widely applicable to the fields of food, healthcare products, medicine and the like.

Description

1. Technical field [0001] The invention belongs to the technical field of plant extraction, and in particular relates to a method for preparing rosmarinic acid. 2. Background technology [0002] Rosmarinic acid is a multifunctional phenolic acid compound that exists in a variety of Lamiaceae plants. In addition to its strong free radical scavenging activity and anti-oxidation in the body, rosmarinic acid also has a significant inhibitory effect on subtilis Bacillus, Bacillus luteus and Escherichia coli reproduce, inhibit HIV-1 reverse transcriptase, antidepressant and other activities, so it has important application value in food, medicine, cosmetics and other fields, and has attracted widespread attention. [0003] There are existing methods for preparing rosmarinic acid from rosemary, such as the paper "Research on the Extraction and Separation and Purification Process of Rosmarinic Acid" written by Zhang Lin et al. This paper introduces the method of separating and puri...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/58C07C67/48C07C67/52
CPCC07C67/48C07C67/52C07C67/58C07C69/732
Inventor 倪科周小华凌梦晨张海龙朱云阳尹思力杨洋
Owner HUNAN XINLI BIOLOGICAL SCI & TECH
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