Micrometer/nanometer multi-level structure titanium dioxide coating with excellent biocompatibility, and preparation method thereof

A biocompatibility, titanium dioxide technology, applied in coating, metal material coating process, drug delivery, etc., can solve problems such as difficulty in obtaining nanostructures, achieve good repeatability, excellent biocompatibility, body torch big effect

Active Publication Date: 2018-09-28
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional plasma spraying technology can prepare macroporous microstructure coatings, but it is difficult to obtain nanostructures

Method used

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  • Micrometer/nanometer multi-level structure titanium dioxide coating with excellent biocompatibility, and preparation method thereof
  • Micrometer/nanometer multi-level structure titanium dioxide coating with excellent biocompatibility, and preparation method thereof
  • Micrometer/nanometer multi-level structure titanium dioxide coating with excellent biocompatibility, and preparation method thereof

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Experimental program
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preparation example Construction

[0028] Contain nano TiO in the present invention 2 Powder spraying liquid can be nano TiO 2 Powder suspension. The nano-TiO 2 The average particle size of the powder can be 10-100 nm, preferably 10-40 nm, which can fully melt the powder and improve the deposition efficiency. The nano-TiO 2 The solvent of the powder spraying liquid material can be at least one of deionized water, ethanol and glycerin. In addition, the nano-TiO 2 Nano TiO in powder spraying liquid 2 The mass ratio of the powder to the solvent can be 3-15%, and the suspension within this value range has a viscosity suitable for spraying and has a good atomization effect. The preparation method of the spray liquid material comprises: TiO with an average particle size of 10-100 nm 2 The powder is dispersed in a solvent (for example, deionized water, etc.) to form a TiO with a solid-to-liquid mass ratio of 3-15%. 2 Powder suspension. TiO 2 The powder suspension is placed in a magnetic stirrer and stirred f...

Embodiment 1

[0034] A. Preparation of spraying liquid material

[0035] Nano TiO 2 The powder (P25, Degussa, Germany) was dispersed in deionized water to form a suspension with a solid-to-liquid ratio of 7%. The suspension was placed in a magnetic stirrer and stirred for 40 minutes, followed by ultrasonication for 20 minutes to obtain a spray coating that could be used for spraying. liquid material. TiO used 2 powder like figure 1 It is shown in the curve of (a).

[0036] B. Preparation of Micro / Nano Hierarchical TiO by Induction Liquid Plasma Ion Spraying (ISPS) Process 2 coatings and micron-sized coatings prepared by atmospheric plasma spraying

[0037] After the surface of the Ti-6Al-4V alloy is sandblasted or sandpaper-polished, it is ultrasonicated twice in absolute ethanol solution, 5 minutes each time, and then dried at 110°C for 1 hour for later use; the pressure of sandblasting treatment is 0.2MPa ;

[0038] Using the induction liquid plasma spraying process (PN-35, TEKNA, ...

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Abstract

The invention relates to a micrometer / nanometer multi-level structure titanium dioxide coating with excellent biocompatibility, and a preparation method thereof, wherein the micrometer / nanometer multi-level structure titanium dioxide coating is obtained by depositing a nanometer-TiO2-powder-containing spraying liquid on the surface of a substrate through a vacuum induction plasma spraying technology. According to the present invention, the preparation method has advantages of simple operation, high efficiency, low pollution, good repeatability and the like, and is suitable for large-scale production.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, in particular to a titanium dioxide (TiO 2 ) coating and its preparation method and application. Background technique [0002] Titanium alloys, stainless steel, and cobalt-chromium-molybdenum are commonly used in the manufacture of orthopedic implants. Depositing porous titanium coatings on the surface of these metal materials can increase the contact area between them and human bone tissue, and help the long-term relationship between the implant and bone tissue. stabilize osseointegration. However, the biological inertness of titanium makes the osseointegration time between it and the host bone longer after implantation, which is prone to loosening and leads to implant failure. Therefore, how to quickly form a stable and durable connection between the implant material and the host bone is an important problem facing the clinical success of bone implants. [0003] Studies have shown that th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C4/134C23C4/10A61L27/30
CPCA61L27/306A61L2400/12A61L2400/18A61L2420/02C01P2002/72
Inventor 顾静萍谢有桃李恺黄利平赵君贺延昌郑学斌
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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