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Drug moisture-proof agent and preparation method and application thereof

A moisture-proof agent and drug technology, which is applied in the direction of pharmaceutical formulas, medical preparations of non-active ingredients, inorganic non-effective ingredients, etc., can solve problems such as limited application fields and insignificant moisture-proof effects

Active Publication Date: 2018-10-12
湖南药圣堂中药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The moisture-proof premix has a good moisture-proof effect, but has the problem that the moisture-proof effect is not significant and the application field is limited

Method used

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  • Drug moisture-proof agent and preparation method and application thereof
  • Drug moisture-proof agent and preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0029] The preparation method of described pharmaceutical moistureproof agent, comprises the following steps:

[0030] S1: dissolving corn gluten in ethanol with a concentration of 95% to make a corn gluten solution with a concentration of 90%-95%, and simultaneously dissolving soluble starch, calcium hydrogen phosphate, and lactose with 50-60ml of hot water at 85-95°C, Then add the corn gluten solution and mix evenly to obtain the premix;

[0031] S2: Dissolve sucrose in 20-30ml of deionized water, add micro-powdered silica gel, stir well, and leave for 1-2 hours to obtain sucrose micro-powdered silica gel mixture;

[0032] S3: Mix the sucrose micropowder silica gel mixture, hydrophobic nano silicon dioxide, maltodextrin, magnesium stearate, hydroxypropyl cellulose, povidone, and then add microcrystalline cellulose and the premix to fully Mix evenly, and then put it into a high-speed mixer to fully stir evenly, adjust the speed of the mixer to 2000-2500r / min, and stir for 15...

Embodiment 1

[0035]A pharmaceutical moisture-proof agent, in parts by weight, comprising the following raw materials: 28 parts of corn gluten, 5 parts of soluble starch, 1.5 parts of calcium hydrogen phosphate, 0.5 parts of lactose, 0.1 part of magnesium stearate, 1.3 parts of microcrystalline cellulose, 0.6 parts of hydroxypropyl cellulose, 0.5 parts of povidone, 0.2 parts of sucrose, 1.2 parts of micronized silica gel, 0.9 parts of hydrophobic nano silicon dioxide, and 0.9 parts of maltodextrin.

[0036] The preparation method of described pharmaceutical moistureproof agent, comprises the following steps:

[0037] S1: Dissolve corn gluten in ethanol with a concentration of 95% to make a corn gluten solution with a concentration of 90%. At the same time, stir soluble starch, calcium hydrogen phosphate, and lactose to dissolve in 50ml of 95°C hot water, then add corn gluten solution and mix well , to obtain the premix;

[0038] S2: Dissolve sucrose in 20ml of deionized water, add micropow...

Embodiment 2

[0042] A pharmaceutical moisture-proof agent, in parts by weight, comprising the following raw materials: 20 parts of corn protein, 15 parts of soluble starch, 1 part of calcium hydrogen phosphate, 0.9 parts of lactose, 0.6 parts of magnesium stearate, 0.8 parts of microcrystalline cellulose, 1.4 parts of hydroxypropyl cellulose, 0.4 parts of povidone, 0.15 parts of sucrose, 1.12 parts of micronized silica gel, 0.62 parts of hydrophobic nano silicon dioxide, and 0.86 parts of maltodextrin.

[0043] The preparation method of described pharmaceutical moistureproof agent, comprises the following steps:

[0044] S1: Dissolve corn gluten in ethanol with a concentration of 95% to make a corn gluten solution with a concentration of 95%. At the same time, stir soluble starch, calcium hydrogen phosphate, and lactose to dissolve in 60ml of 90°C hot water, then add corn gluten solution and mix well , to obtain the premix;

[0045] S2: Dissolve sucrose in 30ml of deionized water, add mic...

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Abstract

The invention discloses a drug moisture-proof agent and a preparation method and application thereof,and belongs to the field of moisture-proof technologies of traditional Chinese medicine preparations. The drug moisture-proof agent comprises zein,soluble starch,calcium hydrophosphate,lactose,magnesium stearate,microcrystalline cellulose,hydroxypropyl cellulose,povidone,cane sugar,micro-powder silica gel,hydrophobic nano silicon dioxide and maltodextrin. The drug moisture-proof agent is prepared in the steps of dissolving,modifying,mixing,stirring and the like. A reinforcing system composed ofthe micro-powder silica gel,the hydrophobic nano silicon dioxide and the maltodextrin is applied to the drug moisture-proof agent,the viscosity and moisture absorption rate of the drug moisture-proofagent are further reduced,and the drug stability is improved.

Description

technical field [0001] The invention belongs to the technical field of moisture-proofing of traditional Chinese medicine preparations, and in particular relates to a medicinal moisture-proofing agent and a preparation method and application thereof. Background technique [0002] According to a certain proportion of traditional Chinese medicine decoction pieces, the preparation raw materials prepared by water extraction or alcohol extraction, concentration, drying and other processes are Chinese medicine extracts. Compared with chemical medicines with single ingredients and clear physical and chemical properties, their ingredients are very complex. And most of the traditional Chinese medicine extracts show bad physical properties such as strong hygroscopicity and poor fluidity. For example, the polysaccharides, tannins, pectin, mucus, resins and other components rich in Chinese medicine extracts are very easy to absorb moisture, and some small molecule alkaloids are also high...

Claims

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Application Information

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IPC IPC(8): A61K47/36A61K47/04A61K47/38A61K47/32A61K47/26A61K47/02A61K47/12
CPCA61K47/02A61K47/12A61K47/26A61K47/32A61K47/36A61K47/38
Inventor 钟振平谢雄吴顺丽
Owner 湖南药圣堂中药科技有限公司
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