A 3D printed magnetic resonance imaging hydrogel and its preparation method and application
A 3D printing, 3D printer technology, applied in MRI/MRI contrast agent, prosthesis, drug delivery, etc., can solve the problems of hydrogel mechanical strength difference in cell culture, lack of research on fine structure and functionalization, etc. , to achieve good physical and chemical properties, conducive to adhesion growth, good mechanical properties
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[0036] The invention provides a kind of preparation method of polycaprolactone-gelatin compound, comprises the steps:
[0037] (1) Add purified gelatin and dimethyl sulfoxide into a flask, heat to 65°C, and prepare a gelatin solution with a mass fraction of 18%;
[0038] (2) Mix polycaprolactone and isophorone diisocyanate evenly and dissolve them in dimethyl sulfoxide to obtain solution A, the mass ratio of polycaprolactone to gelatin is 1:1, gelatin solution and solution A The volume ratio of polycaprolactone is 1:1, the mass ratio of polycaprolactone and isophorone diisocyanate is 30:1, and the molecular weight of described polycaprolactone is 1000~9000;
[0039] (3) After adding 15 drops of dibutyltin dilaurate catalyst dropwise to the above gelatin solution, slowly add the above solution A dropwise, and stir at 65°C for 6.5 hours at a high speed. After the reaction, transfer the product to chloroform, and then precipitate the product into n-hexane and vacuum-dried to obt...
Embodiment 1
[0044] A method for preparing a 3D printed magnetic resonance imaging hydrogel, comprising the steps of:
[0045] (1) Preparation of printing ink: use deionized water as solvent, add polycaprolactone-gelatin complex, methacrylic acid modified gelatin, superparamagnetic iron oxide and photoinitiator, and mix uniformly under magnetic stirring to obtain printed ink The ink was stored in a 34°C water bath for later use; the mass volume concentration of each component in the printing ink was: polycaprolactone-gelatin complex 0.05g / mL, methacrylic acid modified gelatin 0.03g / mL, super Paramagnetic iron oxide 0.1mg / mL and photoinitiator 0.2mg / mL;
[0046] (2) Design and load the 3D model: use 3DS Max software to design the square grid bracket model, then import the model into the 3D printer control software, slice it and design the internal printing structure;
[0047] (3) 3D printing preparation: Transfer the printing ink prepared in step (1) to the extrusion barrel of the extruded...
Embodiment 2
[0050] A method for preparing a 3D printed magnetic resonance imaging hydrogel, comprising the steps of:
[0051] (1) Preparation of printing ink: use deionized water as solvent, add polycaprolactone-gelatin complex, methacrylic acid modified gelatin, superparamagnetic iron oxide and photoinitiator, and mix uniformly under magnetic stirring to obtain printed ink The ink was stored in a 34°C water bath for later use; the mass volume concentration of each component in the printing ink was: polycaprolactone-gelatin complex 0.08g / mL, methacrylic acid modified gelatin 0.04g / mL, super Paramagnetic iron oxide 0.2mg / mL and photoinitiator 0.6mg / mL;
[0052] (2) Design and load 3D model: use 3DS Max software to design the circular grid support model, then import the model into the 3D printer control software, slice it and design the internal printing structure;
[0053] (3) 3D printing preparation: Transfer the printing ink prepared in step (1) to the extrusion cylinder of the extruded...
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