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Composition for treating pharyngitis as well as preparation method and application of composition

A composition and technology for pharyngitis, applied in the field of composition for treating pharyngitis and its preparation, can solve problems such as safety and drug resistance, and achieve good therapeutic effect, relieve clinical symptoms, and good cure rate

Active Publication Date: 2018-10-26
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But safety and drug resistance are also difficult problems in the use of antibiotics

Method used

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  • Composition for treating pharyngitis as well as preparation method and application of composition
  • Composition for treating pharyngitis as well as preparation method and application of composition
  • Composition for treating pharyngitis as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 extract

[0031] Goat horn 94.5g was shredded, hydrolyzed and refluxed twice with alkaline aqueous solution, the filtrate was combined twice, and concentrated; 15.75g kelpite and 23.62g gypsum were crushed into coarse powder, heated and decocted twice, filtered, and the two filtrates were combined. The second filtrate was concentrated to a relative density of 1.01 to 1.04 (75°C to 85°C); artificial bezoar 9.45g was extracted twice with 70% ethanol under reflux, filtered, and the two filtrates were combined, and the ethanol was recovered under reduced pressure and concentrated to a relative density of 1.02~1.05 (75°C~85°C); the remaining four herbs, 47.25g of Fritillaria, 31.5g of Rhubarb, 15.75g of Scutellaria, and 31.5g of Licorice, were decocted twice with water, filtered, and the two filtrates were combined and concentrated to the relative The density is 1.10 (85°C), centrifuge, add ethanol to the supernatant to precipitate, let stand,...

Embodiment 2

[0032] The preparation of embodiment 2 oral liquid

[0033] Take the extract prepared in Example 1 and mix with 0.2% stevia, add water to 1000ml, stir well, boil for 40 minutes, refrigerate for not less than 48h, filter, add water to the filtrate to 1000ml, adjust the pH value to 8.0-9.0, Potting, sterilization, that is.

Embodiment 3

[0034] Embodiment 3 The influence of traditional Chinese medicine composition of the present invention on injection of beta-hemolytic streptococcus-induced inflammation in rats 1 Materials and methods

[0035] 1.1 Experimental animals

[0036] SD rats, half male and half male, 48 rats, weighing 180-220 g, were provided by Shanghai Xipuer-Bikai Experimental Animal Co., Ltd., certificate number: SCXK (Shanghai) 2013-0016.

[0037] 1.2 Experimental drugs and reagents

[0038] The oral liquid that embodiment 2 makes;

[0039] Beta-hemolytic Streptococcus CMCC (B) 32210: China National Institutes for Food and Drug Control;

[0040] Nutrient Broth Medium, Ordinary Agar Medium: China National Institutes for Food and Drug Control;

[0041] Ampicillin Capsules: Hunan Zhonghe Pharmaceutical Co., Ltd.;

[0042]Interleukin-1β radioimmunoassay kit: Beijing Huafulite Biotechnology Research Institute;

[0043] Interleukin-6 radioimmunoassay kit: Beijing Huafulite Biotechnology Research ...

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PUM

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Abstract

The invention provides a composition for treating pharyngitis. The composition is characterized by being prepared from the following raw materials in parts by weight: 5-15 parts of cornu saigae tataricae or 50-150 parts of cornu gorais, 10-60 parts of fritillary bulb, 15-60 parts of rheum officinale, 7-30 parts of radix scutellariae, 7-30 parts of lapis chloriti, 10-50 parts of gypsum, 5-20 partsof calculus bovis factitious and 15-60 parts of liquorice. The composition has good efficacies of relieving sore throat and resisting inflammation, and a certain experimental foundation is provided for the treatment of inflammatory diseases at the throat through clinical use of an oral solution.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a composition for treating pharyngitis, its preparation method and application. Background technique [0002] Acute pharyngitis is the acute inflammation of pharyngeal mucosa, submucosal tissue and lymphoid tissue, is a part of upper respiratory tract infection, and is common in autumn and winter and the turn of winter and spring. It can occur alone or be secondary to acute rhinitis or acute tonsillitis. The onset of this disease is relatively acute. At the beginning, the throat is dry and hot, followed by sore throat. The sore throat is often more obvious when swallowing empty than eating. The pain can radiate to the ear, and the systemic symptoms are generally mild. [0003] At present, Western medicine's response to acute pharyngitis is mainly symptomatic treatment (anti-inflammatory, antipyretic, pain relief, etc.), and antiviral drugs are given for viral infectio...

Claims

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Application Information

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IPC IPC(8): A61K36/8966A61P11/04A61P31/04A61P31/20A61P29/00A61K33/06A61K33/26A61K35/32A61K35/413
CPCA61K33/06A61K33/26A61K35/32A61K35/413A61K36/484A61K36/539A61K36/708A61K36/8966A61K2236/331A61K2236/53A61P11/04A61P29/00A61P31/04A61P31/20A61K2300/00
Inventor 肖伟顾少莉周军曹亮吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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