Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Oleum fructus bruceae, drug composition containing oleum fructus bruceae and preparation method thereof

The technology of bruce japonica oil and bruce brucei, which is applied in the field of medicine, can solve the problems of restricting the preservation of anti-tumor effects of drugs containing bruce nigra oil, increasing heart rate, stimulating blood vessels, and the like.

Active Publication Date: 2018-11-23
沈阳药大雷允上药业有限责任公司
View PDF10 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although drugs containing javanica javanica oil, especially its emulsions, have been widely used, they may appear darkening, demulsification and delamination during placement, and poor stability. These problems clinically cause blood vessel irritation, nausea and vomiting, Adverse reactions such as increased heart rate
These problems existing in the prior art greatly limit the preservation of the drug containing javanica javanica oil and the exertion of the antitumor effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Oleum fructus bruceae, drug composition containing oleum fructus bruceae and preparation method thereof
  • Oleum fructus bruceae, drug composition containing oleum fructus bruceae and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Adopt the javanica javanica oil intermediate of 18% shell rate to prepare javanica javanica oil (sample 2)

[0076] (1) Impurity removal: 151.8kg of the qualified Fructus Bruceae medical material will be checked, and after selecting the foreign matter in Fructus Bruceae, weighing again is 150.6kg,

[0077] (2) Classification: put the de-impured Fructus Brucea medicinal material into the grading unit of the sheller, adopt the rectangular sieve holes of 4.3×25mm, 4.1×25mm, 3.9×25mm, and 3.7×25mm to grade the Fructus Bruceae medicinal material, The Brucea javanica medicinal material is divided into 5 levels. The diameters of the graded Brucea javanica medicinal materials are sorted as follows: the diameter of the first-class Brucea javanica medicinal materials is greater than 4.3mm; The diameter of gallbladder medicinal material ranges from 3.7 to 3.9mm, and the diameter of fifth-grade javanica javanica medicinal material is less than 3.7mm. Take out different grades of ...

Embodiment 2

[0085] Prepare the Brucea javanica intermediate with a shell rate of 14% as medicinal material (sample 3)

[0086] 150.6kg of Brucea javanica medicinal material that is checked is qualified, and step (1)~step (6) is with the step (1)~(6) of embodiment 1. The difference is that, for each grade of Brucea javanica medicinal material, the shelling was repeated 3 times in step (3); for each grade of medicinal material, step (5) was repeated 2 times.

[0087] (7) Brucea javanica oil intermediate: the primary and secondary Brucea javanica medicinal materials collected in step (6) are all combined to obtain the Brucea javanica oil intermediate, and the shell-containing rate of the Brucea javanica oil intermediate is determined to be 14%.

[0088] (8) Extraction of Brucea javanica oil: Carry out the extraction of Brucea javanica oil successively according to the steps (2) to (4) of comparative example 1, wherein the quality of the sherwood oil added in the petroleum ether extraction st...

Embodiment 3

[0090] Adopt the javanica javanica oil intermediate of 5% shell rate to prepare javanica javanica oil (sample 4)

[0091] 152.1kg of the qualified Brucea javanica medicinal material, step (1)~step (6) is the same as the step (1)~(6) of embodiment 1.

[0092] (7) Brucea javanica oil intermediate: the first-class Brucea javanica medicinal material collected in step (6) is the Brucea javanica oil intermediate, and the shell-containing rate of the Brucea javanica oil intermediate is determined to be 5%.

[0093] (8) Extraction of Brucea javanica oil: Carry out the extraction of Brucea javanica oil according to the steps (2) to (4) of comparative example 1 successively, wherein the sherwood oil added in the sherwood oil extraction step is the quality of the javanica javanica intermediate 2.0 times, obtain refined javanica oil 25.4kg.

[0094] The source of the medicinal materials of Brucea javanica used in Comparative Example 1 and Examples 1-3 is the same batch of medicinal mater...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides oleum fructus bruceae and a drug composition containing the oleum fructus bruceae. The oleum fructus bruceae takes fructus brucae javanica with the shell containing rate being 5-20% as a raw material, and is obtained by being extracted from the raw material through petroleum ether with the mass being 1.5-3.0 times, and the acid value is 0.05-2.0. The fructus brucae javanicais subjected to shelling treatment, the acid value and the impurities of the oleum fructus bruceae obtained through extraction are effectively lowered, and accordingly the stability and the safety ofthe oleum fructus bruceae and the preparation thereof are improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a javanica javanica oil, a pharmaceutical composition containing the javanica javanica oil, and their preparation methods. Background technique [0002] Brucea javanica is the dry ripe fruit of Brucea javanica (L.) Merr. Harvest when the fruit is ripe in autumn, remove impurities and dry in the sun. The history of the medication of Brucea javanica was first recorded in "Supplements to Compendium of Materia Medica" written by Zhao Xuemin in the Qing Dynasty. The efficacy recorded in the Pharmacopoeia of the People's Republic of China is clearing away heat and detoxifying, cutting off malaria, stopping dysentery, and corroding warts for external use. In the 1970s, the anti-tumor effect of javanica javanica oil was gradually discovered and recognized, and javanica javanica oil emulsion injection and javanica javanica oil oral emulsion were more widely used in the clinical treatme...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/185A61K9/107A61K47/24A61K47/26C11B1/04C11B1/10C11B3/00C11B3/10C11B3/12A61P35/00A61P35/04A61K131/00
CPCA61K47/24A61K47/26A61K9/0019A61K9/0095A61K9/107A61K36/185C11B1/04C11B1/10C11B3/001C11B3/008C11B3/10C11B3/12A61K2236/35Y02A50/30
Inventor 周浩刘晓庆罗岩索晔张宇董敬杨颖李薇高玥媛徐迪
Owner 沈阳药大雷允上药业有限责任公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com