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Method for encapsulating slightly soluble drugs by ZnO-containing hydrogel beads

A technology of insoluble drugs and hydrogel beads, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, capsule delivery, etc., can solve the problems of poor drug stability and low loading rate of insoluble drugs, and achieves simple, The effect of good pH sensitivity and good sustained release performance

Active Publication Date: 2018-11-30
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Therefore, the technical problem to be solved by the present invention is to overcome the defects of low loading rate of insoluble drugs, serious "burst release" phenomenon and poor drug stability in the prior art, thereby providing a ZnO-containing hydrogel bead that is difficult to encapsulate. Soluble drug method

Method used

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  • Method for encapsulating slightly soluble drugs by ZnO-containing hydrogel beads
  • Method for encapsulating slightly soluble drugs by ZnO-containing hydrogel beads
  • Method for encapsulating slightly soluble drugs by ZnO-containing hydrogel beads

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1 (SA / N-CMCS-ZnO-3)

[0035] This embodiment provides a method for preparing ZnO-containing hydrogel beads, which includes the following steps: first prepare carboxymethyl chitosan-ZnO nanoparticles in situ, and then uniformly add them to an aqueous solution of sodium alginate to chlorinate Calcium acts as a cross-linking agent to form spherical particles. Specific steps are as follows:

[0036] 1g carboxymethyl chitosan was dissolved in 100ml deionized water, heated to 50°C in a magnetic stirrer and stirred for 30min until completely dissolved; 0.595g Zn(NO 3 ) 2 ·6H 2 O was added to the above solution and stirred for 30 minutes; then 50ml of 0.2M NaOH solution was added dropwise, stirred for 2 hours, centrifuged, washed, and dried in an oven at 50°C for 24 hours to obtain ZnO nanoparticles;

[0037] The prepared ZnO nanoparticles were analyzed by X-ray diffraction and scanning electron microscopy, and the specific results were as follows: figure 1 and f...

Embodiment 2

[0040] Example 2 (SA / N-CMCS-ZnO-1)

[0041] This embodiment provides a preparation method of ZnO-containing hydrogel beads, the specific steps are as follows:

[0042] Dissolve 0.5g carboxymethyl chitosan in 100ml deionized water, heat up to 70°C in a magnetic stirrer and stir for 30min until completely dissolved; 0.595g Zn(NO 3 ) 2 ·6H 2 O was added to the above solution and stirred for 30 minutes; then 50ml of 0.3M NaOH solution was added dropwise, stirred for 2 hours, centrifuged, washed, and dried in an oven at 70°C for 24 hours;

[0043] Add 0.01g of the zinc oxide nanoparticles prepared above evenly into 100ml of deionized water, ultrasonic the probe, the ultrasonic power of the probe is 500W, ultrasonic 3s, intermittent 2s, stir well; then add 2g sodium alginate and stir for 1h until uniform; Add it dropwise into 2% calcium chloride solution, let it stand for 12 hours, rinse the surface of the gel with deionized water, and put the gel in an oven at 37°C to dry for 12 h...

Embodiment 3

[0044] Embodiment 3 (SA / N-CMCS-ZnO-2)

[0045] This embodiment provides a preparation method of ZnO-containing hydrogel beads, the specific steps are as follows:

[0046] Dissolve 2g carboxymethyl chitosan in 100ml deionized water, heat up to 80°C in a magnetic stirrer and stir for 30min until completely dissolved; 0.595g Zn(NO 3 ) 2 ·6H 2 O was added to the above solution and stirred for 30 minutes; then 50ml of 0.1M NaOH solution was added dropwise, stirred for 2 hours, centrifuged, washed, and dried in an oven at 80°C for 24 hours;

[0047] Add 0.03g of the zinc oxide nanoparticles prepared above into 100ml of deionized water, ultrasonic the probe, the ultrasonic power of the probe is 400W, ultrasonic 4s, intermittent 1s, stir evenly; then add 3g sodium alginate and stir for 1h until uniform; the above solution is added drop by drop Add 3% calcium chloride solution, let it stand for 12 hours, rinse the surface of the gel with deionized water, and put the gel in an oven a...

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Abstract

The invention belongs to the technical field of drug sustained-release materials and particularly relates to a method for encapsulating slightly soluble drugs by ZnO-containing hydrogel beads. The method comprises: preparing carboxymethyl chitosan-ZnO nanoparticles in situ, adding the carboxymethyl chitosan-ZnO nanoparticles and slightly soluble drugs into an aqueous solution of sodium alginate and preparing spherical particles through calcium chloride as a crosslinking agent. The method is simple and fast and is free of any toxic substance. The hydrogel bead is a spherical particle, has a lowswelling ratio, good pH sensitivity and good sustained release properties, has a release ratio of less than 15% in a simulative gastric juice environment and can be fully released in 7-8h in a simulative intestinal fluid environment.

Description

technical field [0001] The invention belongs to the technical field of drug sustained-release materials, and in particular relates to a method for encapsulating insoluble drugs with ZnO-containing hydrogel beads. Background technique [0002] Among the medical polymer carrier materials, new drug carrier materials occupy a very important position. During the use of the drug, choosing an appropriate carrier material will greatly improve the effectiveness of the drug. An ideal drug carrier should have good drug release performance, good biocompatibility, biodegradability, physical, chemical and biological stability and extremely low cytotoxicity. In recent years, different kinds of drug carrier materials have been developed. In order to improve biocompatibility, the preparation of polymer hydrogels that can be used as drug-controlled release carriers using natural polymers as raw materials has also received attention. [0003] Sodium alginate (SA) is a by-product of extracti...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K31/12A61K31/192A61K33/24A61K31/337A61K47/02A61K47/36
CPCA61K9/5036A61K31/12A61K31/192A61K31/337A61K33/24A61K47/02A61K47/36
Inventor 牛宝龙李文凤王和平王慧芳高向华连小洁
Owner TAIYUAN UNIV OF TECH
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