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Rivastigmine gel paste and preparation method thereof

A technology of rivastigmine gel plaster and plaster applied in the field of pharmacy, which can solve the problems of poor patient compliance and large skin irritation, and achieve the effects of comfortable application, improved gloss, and increased stability

Pending Publication Date: 2018-12-04
ANHUI ANKE YULIANGQING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the transdermal patch was launched in 2007, although it is convenient to use, it is more irritating to the skin and poor in patient compliance.

Method used

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  • Rivastigmine gel paste and preparation method thereof
  • Rivastigmine gel paste and preparation method thereof
  • Rivastigmine gel paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of rivastigmine gel patch

[0029] (1) Weigh 3 parts of carbomer, 0.5 parts of sodium carboxymethylcellulose and 5 parts of povidone K30 respectively, add an appropriate amount of water to fully swell, stir evenly, and then mix evenly to obtain component I;

[0030] (2) Weigh 10 parts of sodium polyacrylate, add glycerin and stir until uniform, add 1 part of vitamin E and stir evenly, add 1 part of rivastigmine, stir evenly, and obtain component II;

[0031] (3) Weigh 0.1 part of disodium edetate and 0.1 part of aluminum glycolate, add water and mix evenly to obtain component III;

[0032] (4) Take an appropriate amount of water, add 0.05 parts of tartaric acid, stir and dissolve to obtain component IV;

[0033] (5) Weigh 0.1 part of ethyl hydroxybenzoate, dissolve it with a small amount of ethanol, add it to component II, then add components I, III, and IV in sequence, and stir for 10 minutes in an airtight, coating, compounding, and cutt...

Embodiment 2

[0034] Embodiment 2: the preparation of rivastigmine gel patch

[0035] (1) Weigh 10 parts of carbomer, 1 part of sodium carboxymethylcellulose and 15 parts of povidone K30 respectively, add an appropriate amount of water to fully swell, stir evenly, and then mix evenly to obtain component I;

[0036] (2) Weigh 30 parts of sodium polyacrylate, add glycerin and stir until uniform, add 3 parts of vitamin E and stir evenly, add 3 parts of rivastigmine, stir evenly, and obtain component II;

[0037] (3) Weigh 0.5 part of disodium edetate and 0.3 part of aluminum glycolate, add water and mix well to obtain component III;

[0038] (4) Take an appropriate amount of water, add 0.2 parts of tartaric acid, stir and dissolve to obtain component IV;

[0039] (5) Weigh 0.3 parts of ethyl hydroxybenzoate, dissolve it with a small amount of ethanol, add it to component II, then add components I, III, and IV in sequence, and stir for 20 minutes in an airtight, coating, compounding, and cutti...

Embodiment 3

[0040] Embodiment 3: the preparation of rivastigmine gel patch

[0041] (1) Weigh 5 parts of carbomer, 0.5 parts of carboxymethylcellulose sodium and 10 parts of povidone K30 respectively, add an appropriate amount of water to fully swell, stir evenly, and then mix uniformly to obtain component I;

[0042] (2) Weigh 20 parts of sodium polyacrylate, add glycerin and stir until uniform, add 2 parts of vitamin E and stir evenly, add 2 parts of rivastigmine, stir evenly, and obtain component II;

[0043] (3) Weigh 0.2 parts of disodium edetate and 0.2 parts of aluminum glycylate in an appropriate amount, add water and mix evenly to obtain component III;

[0044] (4) Take an appropriate amount of water, add 0.1 part of tartaric acid, stir and dissolve to obtain component IV;

[0045] (5) Weigh 0.2 parts of ethylparaben, dissolve it with a small amount of ethanol, add it to component II, then add components I, III, and IV in sequence, and stir for 15 minutes in an airtight, coating, ...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to rivastigmine gel paste and a preparation method thereof. The rivastigmine gel paste comprises a backing film, a drug-loaded gel layer and an anti sticking layer. The drug-loaded gel layer comprises a pharmaceutically active ingredient and a gel matrix, and the pharmaceutically active ingredient is rivastigmine ora pharmaceutically acceptable substance thereof. The drug-loaded gel layer is characterized in that the weight ratio of the pharmaceutically active ingredient to the matrix is 1 to 5:50 to 300, and the matrix is prepared from the following auxiliary materials in parts by weight: 0.5-2 parts of sodium carboxymethylcellulose, 10-100 parts of partially-neutralized sodium polyacrylate, 0.1-2 parts ofdisodium edetate, 5-60 parts of povidone K30, 3-30 parts of carbomer, 30-80 parts of glycerol, 0.1-0.5 parts of ethylparaben, 0.01-2 parts of dihydroxyaluminum aminoacetate, 0.05-0.5 part of tartaricacid, 1-10 parts of vitamin E and 120-200 parts of water. The preparation method of the the rivastigmine gel paste has the advantages of simple process, stable quality, comfortable application, highclinical compliance, little irritation to skin, and large-scale production.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a rivastigmine gel plaster and a preparation method thereof. Background technique [0002] Alzheimer's disease (AD), commonly known as senile dementia, is a serious degenerative disease of the central nervous system. Its pathogenesis may be that the levels of choline acetyltransferase and acetylcholine in the hippocampus and neocortex of patients are significantly reduced, and the cortical cholinergic neuron transmitter function is disordered. Its clinical manifestations mainly include memory impairment, cognitive impairment and mental behavioral impairment. With the arrival of the aging of Chinese society, the number of elderly people is increasing, and more and more elderly people suffer from Alzheimer's disease. Symptoms such as memory loss, slow thinking, and behavioral disturbances have severely affected the work, family, and social relationships of Alzheimer'...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K31/27A61P25/28
CPCA61K9/7061A61K31/27A61P25/28
Inventor 刘道芳刘海兵王琛姜婉君
Owner ANHUI ANKE YULIANGQING PHARMA
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