Compound amoxicillin powder and preparation method thereof

A technology of amoxicillin powder and compound, which is applied in the field of compound amoxicillin powder and its preparation, can solve the problems that the side effects cannot be well reduced, the course of treatment is not significantly shortened, and the dosage is not significantly reduced, so as to solve the problem of bacteria The effect of drug resistance, reduction of drug dosage, and expansion of the scope of indications

Inactive Publication Date: 2018-12-07
新昌县九信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in its practical application: 1. The direct administration of amoxicillin alone has certain limitations in curative effect, and it cannot reduce side effects well; 2. The range of indications is small, The dose reduction is not obvious; 3. The course of treatment has not been significantly shortened

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0021] As above-mentioned a kind of preparation method of compound recipe amoxicillin powder, comprises the steps:

[0022] 1) First weigh the forsythia extract, select No. 4 (65 mesh, 250 μm), No. 6 (100 mesh, 125 μm) and No. 8 (150 mesh, 90 μm) medicine sieves to sieve, cover the sieves and place them on the A close-fitting receiving container is provided under the sieve, and after being rotated and shaken in the horizontal direction for 1, 3, and 5 minutes, the forsythia extract and antioxidants are evenly stirred with a mortar to obtain a mixture;

[0023] 2) Then add water, sodium chloride, ethanol and methanol to the above mixture in sequence, stir continuously for 30 minutes in the range of 25-30 ° C, and obtain the mixed solution after standing for 10 minutes;

[0024] 3) Next, weigh amoxicillin and clavulanic acid, mix the amoxicillin and clavulanic acid in a mass ratio of (3-5): (1-2) and add them into the above mixture for stirring, then Add anti-hygroscopic auxili...

Embodiment 1

[0028] A compound amoxicillin powder, composed of the following parts by mass: 4 parts of amoxicillin, 1 part of clavulanic acid, 0.2 part of antioxidant, 0.5 part of anti-hygroscopic auxiliary material, 1 part of methanol, 0.5 part of ethanol, and 2 parts of sodium chloride , 1 part of ethyl acetate, 1.5 parts of forsythia extract, 3 parts of micro-powdered silica gel and 1.2 parts of phosphate buffer; adding forsythia extract not only enhances the curative effect, but also solves the problem of bacterial drug resistance and reduces toxic and side effects , expand the scope of indications, shorten the course of treatment, take into account both specimens, reduce the amount of medication, and save medicinal materials. Preferably, the antioxidant is sodium bisulfite. Because the forsythia extract has strong reducing properties, it is easy to be oxidized. The oxidizing agent can enhance the stability of the drug. Preferably, the anti-hygroscopic auxiliary material is lactose. Sin...

Embodiment 2

[0035] A compound amoxicillin powder, composed of the following parts by mass: 8 parts of amoxicillin, 1.2 parts of clavulanic acid, 0.5 parts of antioxidant, 0.9 parts of anti-hygroscopic auxiliary materials, 1.2 parts of methanol, 0.8 parts of ethanol, and 2.1 parts of sodium chloride , 1.5 parts of ethyl acetate, 2.5 parts of forsythia extract, 3.7 parts of micro-powdered silica gel and 1.6 parts of phosphate buffer; adding forsythia extract not only enhances the curative effect, but also solves the problem of bacterial drug resistance and reduces toxic and side effects , expand the scope of indications, shorten the course of treatment, take into account both specimens, reduce the amount of medication, and save medicinal materials. Preferably, the antioxidant is sodium metabisulfite. Because the forsythia extract has strong reducing properties, it is easy to be oxidized. By increasing antioxidants, it can To enhance the stability of the drug, preferably, the anti-hygroscopic...

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PUM

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Abstract

The invention discloses compound amoxicillin powder and a preparation method thereof. The compound amoxicillin powder is prepared from the following components in parts by mass: 4-20 parts of amoxicillin, 1-2 parts of clavulanic acid, 0.2-1.5 parts of antioxidant, 0.5-2.5 parts of moisture absorption resistant auxiliaries, 1-2 parts of methanol, 0.5-1.5 parts of ethanol, 2-2.5 parts of sodium chloride, 1-3 parts of ethyl acetate, 1.5-5 parts of fructus forsythia extract, 3-6 parts of aerosil and 1.2-2.5 parts of phosphate buffer. The preparation method comprises the following steps: sequentially adding the water, sodium chloride, ethanol and methanol into the fructus forsythia extract and antioxidant to obtain a mixed solution; weighing amoxicillin and clavulanic acid, adding into the mixed solution; and adding the moisture absorption resistant auxiliaries, ethyl acetate, phosphate buffer and aerosol to obtain the compound amoxicillin powder. According to the compound amoxicillin powder, the curative effect is reinforced, the problem of bacterial drug resistance can be solved, toxic and side effects can be reduced, the indication range is enlarged, the course of treatment can be shortened, the dosage can be reduced, and medicinal materials can be saved.

Description

technical field [0001] The invention relates to a compound amoxicillin powder and a preparation method thereof. Background technique [0002] Amoxicillin belongs to β-lactam antibiotics, also known as amoxicillin, its chemical name is (2S, 5R, 6R)-3,3-dimethyl-6-[(R)-(-)-2- Amino-2-(4-hydroxyphenyl)acetamido]-7-oxo-4-thia-1-azabicyclo[3,2,0]heptane-2-carboxylic acid trihydrate, semi-synthetic Spectrum antibiotics, the potassium or sodium salts are generally used clinically, which are easily soluble in water, but hardly soluble in organic solvents. Because of its good antibacterial effect, it is widely used to treat sensitive bacterial infections in pigs, cattle and poultry. [0003] At present, amoxicillin powder is widely used in veterinary clinics to prevent and treat infectious diseases of the respiratory tract, digestive tract, genitourinary tract and skin and soft tissues caused by pathogenic bacteria in livestock and poultry, with good results. However, there are st...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/634A61K9/14A61K47/04A61K47/26A61P31/04A61K31/43A61K31/424
CPCA61K9/143A61K9/145A61K31/424A61K31/43A61K36/634A61P31/04A61K2300/00
Inventor 周海云周卫平陈峰蔡兰兰丁学锋
Owner 新昌县九信药业有限公司
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