Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of preparation method of poly-L-lactic acid/iron tetroxide composite bone scaffold

A technology of ferroferric oxide and poly-L-lactic acid, which is applied in processing and manufacturing, solid material additive processing, additive processing, etc., can solve the problems of limited application, easy agglomeration, and reduction of magnetic saturation strength of nanoparticles to achieve enhanced cell Active, bone regeneration promoting, environmentally friendly effects

Active Publication Date: 2020-10-02
CENT SOUTH UNIV
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However Fe 3 o 4 Nanoparticles have the problem of easy agglomeration in the polymer matrix, because the PLLA / Fe prepared by the current existing technology 3 o 4 Composite Fe 3 o 4 The surface is modified, such as polyethylene glycol, silica, etc., and then dispersed in organic solvents such as chloroform, which will reduce the Fe 3 o 4 Magnetic saturation of nanoparticles or residual toxic reagents, limiting their use in biomedicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1) Use the SolidWorks 3D design software to design the porous structure and individual shape of the composite scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer;

[0043] 2) Use an electronic balance to weigh 3.9 g of PLLA powder with a particle size of 80 μm and Fe powder with a particle size of 20 nm. 3 o 4 Powder 0.1g, then add respectively in the beaker that is equipped with 50ml and 10ml ethanol, to PLLA-ethanol solution and Fe 3 o 4 - Ultrasonic dispersion in ethanol solution, prepared with 2.5wt% Fe 3 o 4 composite powder. The main process parameters are: ultrasonic dispersion time is 40min, temperature is 50℃;

[0044] 3) The dispersed Fe 3 o 4 -The ethanol solution was added dropwise into the PLLA-ethanol solution at a dropping speed of 1ml / s for mixing, and then dispersed using ultrasonic and ball milling techniques. The main process parameters were...

Embodiment 2

[0050] 1) Use the SolidWorks 3D design software to design the porous structure and individual shape of the composite scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer;

[0051] 2) Use an electronic balance to weigh 3.8 g of PLLA powder with a particle size of 80 μm and Fe powder with a particle size of 20 nm. 3 o 4 Powder 0.2g, then add respectively in the beaker that is equipped with 50ml and 10ml ethanol, to PLLA-ethanol solution and Fe 3 o 4 - Ultrasonic dispersion in ethanol solution, prepared with 5wt% Fe 3 o 4 composite powder. The main process parameters are: ultrasonic dispersion time is 40min, temperature is 50℃;

[0052] 3) The dispersed Fe 3 o 4 -Ethanol solution was added dropwise to PLLA-ethanol solution at a rate of 1.2ml / s for mixing, and then dispersed using ultrasonic and ball milling techniques. The main process parameters were: ultrasonic dispers...

Embodiment 3

[0058] 1) Use the SolidWorks 3D design software to design the porous structure and individual shape of the composite scaffold, import the designed 3D data model into the computer for layered slice processing, and obtain the cross-sectional profile information of each layer;

[0059] 2) Use an electronic balance to weigh 3.7 g of PLLA powder with a particle size of 80 μm and Fe powder with a particle size of 20 nm. 3 o 4Powder 0.3g, then add respectively in the beaker that is equipped with 50ml and 10ml ethanol, to PLLA-ethanol solution and Fe 3 o 4 - Ultrasonic dispersion in ethanol solution, prepared with 7.5wt% Fe 3 o 4 composite powder. The main process parameters are: ultrasonic dispersion time is 40min, temperature is 50℃;

[0060] 3) The dispersed Fe 3 o 4 -Ethanol solution was added dropwise to PLLA-ethanol solution at a rate of 1.5ml / s for mixing, and then dispersed using ultrasonic and ball milling techniques. The main process parameters were: ultrasonic disper...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
melting pointaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention provides a preparation method of a poly L-lactic acid / ferroferric oxide compound bone support. An ethanol solution with Fe3O4 powder dispersed therein is dropwise added to an ethanol solution with PLLA (poly L-lactic acid) powder dispersed therein; a mixed solution is obtained through ultrasonic dispersion and ball milling; a solid phase obtained by solid-liquid separation is dried and ground to obtain composite powder; and the PLLA / Fe3O4 composite bone support is obtained through the selective laser sintering of the composite powder. Fe3O4 particles and PLLA particles are uniformly dispersed in the mixed solution through the ultrasonic dispersion and ball milling in a liquid phase system; the magnetic PLLA / Fe3O4 composite bone support is prepared through the selective lasersintering; and the Fe3O4 particles and PLLA particles which are uniformly dispersed have a very good interface bonding performance and can effectively improve the mechanical property of the bone support. The magnetism of nanometer Fe3O4 can produce magnetic stimulation on bone cells, so that the adhesion, proliferation and differentiation of the bone cells on the obtained magnetic PLLA / Fe3O4 composite bone support can be promoted.

Description

technical field [0001] The invention relates to a preparation method of a poly-L-lactic acid / ferric oxide composite bone scaffold, belonging to the technical field of bone scaffold preparation. Background technique [0002] At present, due to the unlimited source of artificial bone transplantation, it can be customized according to needs, which has attracted extensive attention from domestic and foreign researchers. Because polymer materials have good biological properties, they are widely used as artificial bone graft materials, among which poly-L-lactic acid (PLLA) is a biodegradable and non-toxic polymer material with good biocompatibility, which is considered to be the A promising bone scaffold material. However, after the PLLA bone scaffold is implanted in the bone defect site, the phenomenon of delayed union or nonunion will occur due to the loss or death of cell activity during the bone repair process, and PLLA is brittle and hydrophobic, which is not conducive to th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/153B33Y10/00B33Y70/10B29K67/00B29K505/12
CPCB29C64/153B29K2067/046B29K2505/12B33Y10/00B33Y70/00
Inventor 冯佩帅词俊
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com