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Double-release type calcium polycarbophil granules as well as preparation method and application in livestock and poultry

A technology of polycarbophil calcium and granules, which is applied in the fields of feed additives, veterinary drugs and premixes, and can solve the problems of unseen applications, and achieve the effects of prevention and control, increasing porosity, and delaying release time

Active Publication Date: 2018-12-18
ZHEJIANG ESIGMA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The application of polycarbophil calcium in humans has been reported, but there is no report on the application in livestock and poultry breeding

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Embodiment 1: Preparation of double-release polycarbophil calcium granules

[0066] A kind of double-release polycarbophil calcium granules, composed of 50% by mass percentage slow-release core layer, 30% quick-release outer layer and 20% gastric-soluble coating material layer, wherein

[0067] The sustained-release core layer is processed from the following components in mass percentage:

[0068] Calcium Polycarbophil 10%

[0069] Gluten 20%

[0070] Hydroxypropyl Cellulose 30%

[0071] Plasticizer 20%

[0072] Surfactant 2%

[0073] The balance is pure water;

[0074] The quick-release outer layer is processed from the following components in mass percentage:

[0075] Calcium Polycarbophil 50%

[0076] Propylene Glycol 5%

[0077] Binder 20%

[0078] Disintegrant 8%

[0079] The balance is pure water.

[0080] In the present invention, the binder is white carbon black, the disintegrant is sodium carboxymethyl starch, the plasticizer is polyethylene, and the...

Embodiment 2

[0090] Embodiment 2: Preparation of double-release polycarbophil calcium granules

[0091] A double-release polycarbophil calcium granule is composed of a sustained-release core layer with a mass percentage of 60%, an immediate-release outer layer with 20% and a gastric-soluble coating material layer with 20%.

[0092] The sustained-release core layer is processed from the following components in mass percentage:

[0093] Calcium Polycarbophil 8%

[0094] Gluten 28%

[0095] Hydroxypropyl Cellulose 22%

[0096] Plasticizer 10%

[0097] Surfactant 2%

[0098] The balance is pure water;

[0099] The quick-release outer layer is processed from the following components in mass percentage:

[0100] Calcium Polycarbophil 50%

[0101] Propylene Glycol 5%

[0102] Binder 20%

[0103] Disintegrant 8%

[0104] The balance is pure water.

[0105] In the present invention, the binder is dextrin, the disintegrant is low-substituted hydroxypropyl cellulose, the plasticizer is acr...

Embodiment 3

[0115] Embodiment 3: the preparation of double-release polycarbophil calcium granules

[0116] A double-release polycarbophil calcium granule is composed of a slow-release core layer with a mass percentage of 70%, an immediate-release outer layer with 10% and a gastric-soluble coating material layer with 20%.

[0117] The sustained-release core layer is processed from the following components in mass percentage:

[0118] Calcium Polycarbophil 10%

[0119] Gluten 30%

[0120] Hydroxypropyl Cellulose 15%

[0121] Plasticizer 15%

[0122] Surfactant 2%

[0123] The balance is pure water;

[0124] The quick-release outer layer is processed from the following components in mass percentage:

[0125] Calcium Polycarbophil 60%

[0126] Propylene Glycol 5%

[0127] Binder 20%

[0128] Disintegrant 8%

[0129] The balance is pure water.

[0130] In the present invention, the binder is corn starch, the disintegrant is sodium carboxymethyl starch, the plasticizer is silicone ru...

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PUM

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Abstract

The invention relates to double-release type calcium polycarbophil granules as well as a preparation method and application in livestock and poultry and belongs to the field of veterinary drugs and premix. The double-release type calcium polycarbophil granules provided by the invention are prepared by spraying and coating a rapid-release outer layer on a slow-release core layer and granulating, then spraying and coating a gastric dissolve type coating material and drying. The calcium polycarbophil granules provided by the invention can be rapidly released in stomachs and are slowly released after reaching intestines; the retention time of calcium polycarbophil in the intestines is prolonged and the diarrhea relieving effect is remarkable. The calcium polycarbophil is not absorbed in the intestines, is not retained and can be used for replacing antibiotics in livestock and poultry breeding.

Description

technical field [0001] The invention belongs to the field of feed additives, in particular to a double-release polycarbophil calcium granule and its preparation method and application in livestock and poultry, and belongs to the field of veterinary medicine and premix. Background technique [0002] Calcium polycarbophil (Calcium polycarbophil) was originally developed by Abbott in the United States as a drug for the treatment of irritable bowel syndrome (irritable bowel syndrome, IBS). It has been widely used in Europe, America and Japan for IBS and various For the relief of constipation symptoms, it was also approved for marketing in China in 2011. [0003] The active ingredient of polycarbophil calcium is diethylene glycol cross-linked acrylic acid copolymer calcium salt, a resin with strong hydrophilicity and high water absorption performance. The molecular formula is (C6H6CaO4)a·(C6H10O2)b . Polycarbophil calcium has very unique biochemical properties. It can quickly r...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/78A61K47/42A61K47/38A61K47/10A61K47/22A61P1/12A23K20/00A23K50/30A23K50/75
CPCA61K9/5036A61K9/5047A61K31/78A61K47/10A61K47/22A61K47/38A61K47/42A23K20/00A23K50/30A23K50/75A61P1/12Y02A40/70
Inventor 徐天华王贤玉张丽佳陈贵才
Owner ZHEJIANG ESIGMA BIOTECH CO LTD
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