Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-wrinkle cosmetic containing oligomeric glutamic acid and preparation method of anti-wrinkle cosmetic

An anti-wrinkle cosmetic, polyglutamic acid technology, applied in cosmetic preparations, cosmetics, medical preparations containing active ingredients, etc., to achieve outstanding anti-wrinkle properties, promote regeneration, and delay aging.

Pending Publication Date: 2018-12-25
SHANDONG FREDA BIOTECH
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, high-molecular-weight polyglutamic acid is used as a moisturizer in cosmetics, and there is no report on the use of polyglutamic acid as an anti-wrinkle agent

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-wrinkle cosmetic containing oligomeric glutamic acid and preparation method of anti-wrinkle cosmetic
  • Anti-wrinkle cosmetic containing oligomeric glutamic acid and preparation method of anti-wrinkle cosmetic
  • Anti-wrinkle cosmetic containing oligomeric glutamic acid and preparation method of anti-wrinkle cosmetic

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0024] The preparation method of the rye columbine extract is as follows: crush the cleaned rye columbine, add 2-5 times of 50-70% ethanol solution, ultrasonically extract for 1-2 hours to obtain a mixture, and then add enzyme preparation to the mixture (According to the mass ratio, pectinase: cellulase: protease = 1:1:1 mixture) 0.1-2%, pH 7.0, temperature 50°C, enzymolysis for 2-5h, heat up to 90°C to kill the enzyme. The resulting mixture was centrifuged, the supernatant was concentrated, and freeze-dried to obtain the rye coax extract. Pectinase, cellulase and protease require enzyme activity ≥ 10,000 U / g.

[0025] Wherein the preparation method of the green tea extract is as follows: clean, dry and pulverize the green tea leaves, add 60-80% ethanol solution, ultrasonically extract for 1-2 hours at a temperature of 55-70°C, filter after cooling slightly, and carry out secondary extraction of the residue Extraction, the two extracts are mixed, concentrated by rotary evapor...

Embodiment 1

[0026] Example 1: Anti-wrinkle efficacy experiment of polyglutamic acid with different molecular weights

[0027] Table 1 Sodium Polyglutamate Molecular Weight and Content

[0028]

[0029] Dissolve the sodium polyglutamate with different molecular weights in the above table 1 in sterile water at 60°C respectively, stir and dissolve, then add phenoxyethanol and propylene glycol into the dissolved sodium polyglutamate solution after miscibility, Stand-by, the concentrations of phenoxyethanol and propylene glycol in the solution are both 0.5%. Select 80 volunteers (40 males and females, aged between 30 and 50 years old), with dry skin and obvious wrinkles, and randomly divide them into 4 groups, apply the sodium polyglutamate solution of different molecular weights in the above table 1 evenly on the left face sooner or later , Apply sterile water to the right face. The evaluation indicators are as follows, anti-wrinkle degree, expressed in the coefficient range of 0-10: 10 ...

Embodiment 2-4

[0035] Table 3 oligoglutamic acid anti-wrinkle cosmetic formulation

[0036]

[0037] Dissolve ectoine, ascorbic acid, green tea extract, EDTA-Na and sodium dehydroacetate in the above Table 3 in sterile water at room temperature according to the formula ratio, and stir until dissolved; then mix phenoxyethanol with propylene glycol After dissolving, add it to the above-mentioned solution that has been dissolved, and finally add 1000-6000Da oligomeric sodium glutamate, seaweed extract and rye seed extract compound respectively according to the embodiment 2-4 in the following table, stir and dissolve, Made into an anti-wrinkle serum.

[0038] Table 4 Different anti-wrinkle active ingredients and content

[0039]

[0040]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Average molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention discloses an anti-wrinkle cosmetic containing oligomeric glutamic acid and a preparation method of the anti-wrinkle cosmetic. The main functional component of the cosmetic is 1000-6000 Da of the oligomeric glutamic acid, and the oligomeric glutamic acid which serves as a biological active peptide is independently used or is combined to other natural anti-wrinkle substances such as asea algae extract and a rye seed extract and has an anti-wrinkle effect. In addition, the cosmetic further comprises moisturizing agents such as ectoin, propylene glycol, glycerinum, sodium lactate, an antioxidant such as ascorbic acid and salt, a green tea extract, EDTA and salt, and citric acid. The cosmetic has multiple effects of resisting wrinkles, whitening skin, moisturizing and the like, does not have side effects, and is suitable for people with various skins.

Description

technical field [0001] The invention belongs to the field of cosmetics and relates to an anti-wrinkle cosmetic and a preparation method thereof. Background technique [0002] Wrinkle formation is an external sign of human vitality and natural aging of the skin. It is impossible to completely eliminate wrinkles. Only some methods can delay or reduce wrinkles. Cosmetics are more commonly used and high-end products for skin surface anti-wrinkle. In order to better meet the needs of consumers, different types of anti-wrinkle functional ingredients are added to cosmetics, but the current skin care products mostly use chemical preparations, which are highly irritating to the skin, have large side effects, and are prone to allergies. [0003] Polyglutamic acid (γ-PGA) is a high-molecular amino acid polymer obtained by microbial fermentation (the molecular weight of polyglutamic acid obtained by microbial fermentation is usually above 700kDa), and its molecular chain has a large num...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K8/9794A61K8/9706A61K8/88A61Q19/08A61Q19/02A61Q19/00
CPCA61K8/88A61K2800/592A61Q19/00A61Q19/02A61Q19/08A61K8/9706A61K8/9794
Inventor 李珍爱李海军苏移山马双双王庆波李艳艳王兆兰张英华
Owner SHANDONG FREDA BIOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com