Tyrosine-derived amygdalin-loaded hydrogel preparation method and application
A technology of amygdalin and hydrogel, which is applied to medical preparations containing no active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve traumatic brain injuries that cannot be directly affected and are difficult to achieve curative effect and other problems, to achieve good anti-inflammatory effect, low cost and easy injection
Active Publication Date: 2019-01-04
XIANGYA HOSPITAL CENT SOUTH UNIV
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Abstract
The invention discloses a tyrosine-derived amygdalin-loaded hydrogel preparation method and application. The method includes: dissolving Fmoc-Tyr-OH solid powder into dimethyl sulfoxide, and ultrasonically dispersing to obtain Fmoc-Tyr-OH stock solution; dissolving amygdalin solution with ultrapure water to obtain amygdalin stock solution; well mixing Fmoc-Tyr-OH stock solution and amygdalin stocksolution, and standing to obtain tyrosine-derived amygdalin-loaded hydrogel. The tyrosine-derived amygdalin-loaded hydrogel has anti-inflammatory characteristics, the problem of failure in direct application of amygdalin monomer to traumatic brain injured parts can be solved, bioactivity of amygdalin is kept, and evident treatment effects are achieved in application to treatment of inflammatory reaction caused by traumatic brain injuries.
Application Domain
Organic active ingredientsNervous disorder +8
Technology Topic
Anti-inflammatoryChemistry +12
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PUM
Property | Measurement | Unit |
Concentration | 50.0 ~ 100.0 | mg/ml |
Concentration | 1.0 ~ 16.0 | mg/ml |
Diameter | 5.0 | mm |
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