Curing liquid applicable to calcium phosphate-based bone cement as well as preparation method and application of curing liquid

A technology of bone cement and calcium phosphate, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problem of reducing the early curing strength of the cured body, not improving the hydration reaction ability of CPC curing raw materials, shortening the curing time of calcium phosphate bone cement, etc. problems, to achieve the effect of expanding medical value, achieving early strength and late strength, and improving curing ability

Active Publication Date: 2019-01-04
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

All in all, although the current research results can improve the hydration performance of calcium phosphate bone cement, most of the additives have the problem of shortening the curing time of calcium phosphate bone cement but reducing the early curing strength of the solidified body; there is no fundamental effect from the perspective of hydration reaction. Improve the hydration reaction ability of CPC curing raw materials

Method used

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  • Curing liquid applicable to calcium phosphate-based bone cement as well as preparation method and application of curing liquid
  • Curing liquid applicable to calcium phosphate-based bone cement as well as preparation method and application of curing liquid
  • Curing liquid applicable to calcium phosphate-based bone cement as well as preparation method and application of curing liquid

Examples

Experimental program
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Effect test

preparation example Construction

[0046] 4. Preparation of Curing Solution

[0047] The solidification liquid used in the embodiment is prepared by the following method:

[0048] (1) Dissolving a certain dose of citric acid to prepare solution A;

[0049] (2) Add a certain amount of sodium phosphate salt to A to obtain B;

[0050] (3) Add a certain amount of PVP to B to obtain C;

[0051] (4) Add a certain amount of PVA to C, and stir at 80°C for 30 minutes to obtain D;

[0052] (5) Cool D for later use.

Embodiment 1

[0053] Embodiment 1 The preparation of calcium phosphate bone cement solid phase and solidification solution

[0054] 1. Preparation of the Solid Phase of Calcium Phosphate Bone Cement

[0055] (1) CPC-1

[0056] Calcium dihydrogen phosphate-α-tricalcium phosphate-calcium carbonate bone cement: mix 3-10wt% calcium dihydrogen phosphate, 80-92wt% α-tricalcium phosphate, and 5-10wt% calcium carbonate to obtain calcium phosphate bone cement cement solid phase.

[0057] (2) CPC-2

[0058] α-tricalcium phosphate (60-80wt%), tetracalcium phosphate (TECP) (20-30wt%) and hydroxyapatite (HAP) (1-10wt%) are uniformly mixed to solidify the calcium phosphate bone cement.

[0059] 2. Preparation of Curing Solution

[0060] According to the formula in Table 1 (the balance is water), the solidified solutions numbered L1-L10 were respectively prepared.

[0061] The formula of table 1 curing liquid

[0062] Composition (wt%)

Embodiment 2

[0063] Embodiment 2 physical and chemical performance detection

[0064] The calcium phosphate bone cement prepared in Example 1 was mixed with the solidification solution at a liquid-solid ratio of 0.5 mL / g, and the physical and chemical properties were tested as follows after solidification.

[0065] 1. Curing time test

[0066] The test of setting time was carried out according to ASTM C190-03 of the American Society for Testing and Materials. The weight of the indenter of the Vicat instrument used is 300±0.5g, and the diameter of the needle is 1±0.05mm. The test steps are as follows: After the sample is reconciled, put it into a constant temperature and humidity box at 37°C and 95% humidity, start timing from the time when the solidification solution is added, relax the pressure head, and the test needle sinks freely into the slurry, when the test needle sinks less than 25mm When the test needle has no obvious indentation on the surface of the sample, it reaches the fina...

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Abstract

The invention provides curing liquid applicable to calcium phosphate-based bone cement as well as a preparation method and application of the curing liquid. The curing liquid applicable to the calciumphosphate-based bone cement comprises the following components by mass percentage: 2-9% of citric acid, 1-6% of PVP, 5-25% of phosphate and 1-5% of PVA. The invention creatively utilizes the abilityof phosphate to promote early hydration products; an acidic environment is provided by citric acid; PVP has a molecular mediated effect on calcium phosphate deposition; PVA has a water-retaining function; through the synergistic effect of citric acid, phosphate, PVP and PVA, the mechanical properties of calcium phosphate bone cement such as curing ability, early strength, late strength and the like are significantly improved, the medical value of calcium phosphate bone cement is expanded, at the same time, calcium phosphate bone cement is closer to clinical use standards, and calcium phosphatebone cement has broad application prospects.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to a solidification solution suitable for calcium phosphate-based bone cement, a preparation method and application thereof. Background technique [0002] Calcium phosphate cement (CPC) is composed of powder and solidification solution mixed with one or more calcium phosphate salts. When used, the two are mixed in a certain proportion, and can be cured and plasticized at room temperature or in the human body environment. The hydration reaction is mainly converted into hydroxyapatite (HA), which can guide bone growth, gradually be absorbed by tissue and produce bone tissue regeneration effect, has good biocompatibility, and has great clinical application advantages in bone defect repair However, the material still has shortcomings, especially it is not easy to solidify quickly during the implantation process, which reduces the strength of the mat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/16A61L27/12A61L27/50
CPCA61L27/12A61L27/16A61L27/50A61L2430/02C08L39/06C08L29/04
Inventor 于涛孙琳周长忍
Owner JINAN UNIVERSITY
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