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Preparation and application of non-enzymatic nickel oxide and reduced graphene oxide composite electrode

A composite material, nickel oxide technology, applied in the direction of material electrochemical variables, etc., can solve the problem of large internal resistance

Inactive Publication Date: 2019-01-04
HARBIN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Nickel oxide has a high isoelectric point (10.7), good chemical stability, electrocatalytic performance and biocompatibility. The surface of flaky nickel oxide has a large number of active sites, but the internal resistance is large

Method used

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  • Preparation and application of non-enzymatic nickel oxide and reduced graphene oxide composite electrode
  • Preparation and application of non-enzymatic nickel oxide and reduced graphene oxide composite electrode
  • Preparation and application of non-enzymatic nickel oxide and reduced graphene oxide composite electrode

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specific Embodiment approach 1

[0026] Specific embodiment 1: The method for preparing a nickel oxide reduction graphene oxide composite electrode in this embodiment is specifically carried out according to the following steps:

[0027] 1. Hydrothermal method to prepare nickel hydroxide nanosheets

[0028] 1) 20-30 mM Ni(NO 3 ) 2 ·6H 2 O and 50-60 mM hexamethylenetetramine were dissolved in 75ml of deionized water, placed in a magnetic stirrer and stirred until it was completely dissolved, the solution turned light green. Step 1) The stirring rate of the magnetic stirrer is 200-400r / min; the magnetic stirring is actually carried out at room temperature;

[0029] 2) The light green solution in step 1) is transferred to the stainless steel autoclave. Hydrothermal reaction at 100-140℃ for 4-8 h. Step 1 2) The inner lining of the stainless steel high-pressure reactor is polytetrafluoroethylene;

[0030] 3) Step 1 2) The product obtained by the hydrothermal reaction is suction filtered, then washed with deionized water...

specific Embodiment approach 2

[0038] The second embodiment: This embodiment is different from the first embodiment: in step 1), 24-28mM Ni(NO 3 ) 2 ·6H 2 O and 52-58 mM hexamethylenetetramine are dissolved in 75ml of deionized water, and placed in a magnetic stirrer for stirring. Others are the same as in the first embodiment;

specific Embodiment approach 3

[0039] Specific embodiment three: This embodiment is different from one of specific embodiments one or two in that: step two 2) is added in Ni(OH) 2 The mass ratio of the nanosheets to the graphene oxide is 1:1, and the rest is the same as the first or second embodiment.

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Abstract

The invention relates to preparation of a non-enzymatic nickel oxide and reduced graphene oxide composite electrode and application of the electrode to electrochemical detection of dopamine. By meansof the electrode, the problems that when existing materials are used for detecting dopamine, enzyme modification is needed, and the sensitivity and selectivity are poor are solved. The preparation method mainly comprises the steps of 1, preparing nickel hydroxide nanosheets by means of a hydrothermal method; 2, preparing a nickel hydroxide and graphene oxide composite electrode by means of an automatic spraying method; 3, preparing the nickel oxide and graphene oxide composite electrode by means of a thermal reduction method. The prepared non-enzymatic nickel oxide and reduced graphene oxide composite electrode has the advantages of large specific surface area, high electrical conductivity, good biocompatibility and the like, and can be used as an electrode material for detecting dopamine.

Description

Technical field [0001] The invention relates to an enzyme-free nickel oxide reduction graphene oxide composite electrode preparation and electrochemical detection of dopamine. Background technique [0002] Enzyme-based biosensors occupies a large proportion of the entire biosensor, but enzyme-based biosensors have many shortcomings, such as difficulty in storage, high price and poor stability, so it is very important to develop an enzyme-free biosensor. [0003] As an important neurotransmitter, dopamine (DA) plays an important role in the central nervous system, kidney and endocrine system. Insufficiency or imbalance of dopamine can make people lose the ability to control muscles or cause inability to concentrate; the former can cause involuntary tremor of hands and feet, and even suffer from Parkinson's disease in severe cases. The content of dopamine in the human body is very low, and uric acid (UA) and dopamine coexist in the human body, so how to accurately detect dopamine un...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
CPCG01N27/30
Inventor 岳红彦张宏杰高鑫
Owner HARBIN UNIV OF SCI & TECH