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Composite hemostatic material for external trauma and preparation method thereof

A technology of hemostatic material and porous material, which is used in pharmaceutical formulations, bandages, drug delivery, etc., can solve the problem of inability to achieve rapid hemostasis in acute bleeding, and achieve the effects of easy long-term storage, high safety, and good biocompatibility.

Pending Publication Date: 2019-01-11
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the domestic traditional topical hemostatic powder cannot achieve the effect of rapid hemostasis on acute bleeding caused by arterial trauma

Method used

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  • Composite hemostatic material for external trauma and preparation method thereof
  • Composite hemostatic material for external trauma and preparation method thereof
  • Composite hemostatic material for external trauma and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A preparation method of a composite hemostatic material for trauma, comprising the following steps:

[0041] (1) Diatomaceous earth and calcium nitrate solution are mixed evenly, and the mass ratio of diatomite and calcium nitrate is 5:1, room temperature is dried, then gained material is dried, roasted 12 hours at 500 degrees centigrade;

[0042] (2) dissolving chitosan in water, adding the porous material processed in step (1), the mass ratio of porous material and chitosan is 20:1, mix well, and dry.

Embodiment 2

[0044] A preparation method of a composite hemostatic material for trauma, comprising the following steps:

[0045] (1) Mix porous material activated carbon, diatomite, kaolin, and montmorillonite with sodium sulfate, calcium nitrate, and ferric chloride solution in a ratio of 1:1:1:1, and the mass ratio of porous material to inorganic salt is 10 : 1, room temperature drying, then gained material is dried, roasted 5 hours at 600 degrees centigrade;

[0046] (2) Dissolve the agarose in water, add the porous material treated in step (1), the mass ratio of the porous material to the agarose is 4:1, mix evenly, and dry.

Embodiment 3

[0048] A preparation method of a composite hemostatic material for trauma, comprising the following steps:

[0049] (1) Dissolve the surfactant (cetyltrimethylammonium bromide) in an aqueous solution of calcium chloride, add sodium silicate under stirring, continue to stir evenly, and let stand for 24 hours, the reaction temperature is 5-80 degrees Celsius The mass ratio of the synthetic components is surfactant: sodium silicate=5:1, calcium chloride aqueous solution: sodium silicate=50:1 (mass ratio); the concentration of calcium chloride aqueous solution is 10mmol / L;

[0050] (2) Heat the material obtained in step (1) at 100°C for 24 hours, filter and dry the material; after drying, bake at 700°C for 12 hours to obtain the artificially synthesized porous material.

[0051] (3) the artificially synthesized porous material obtained in step (2) is mixed evenly with sodium dihydrogen phosphate solution, the mass ratio of the artificially synthesized porous material and sodium di...

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Abstract

The invention discloses a composite hemostatic material for external trauma and a preparation method thereof. The hemostatic material comprises a porous material, a metal oxide and a high molecular polysaccharide, and the mass ratio is 1: 0.50-0.01: 5-0.05, and the pore size range of the porous material is 1 nm-100 mu m. The material has porous structure, can quickly adsorb various proteins in blood, so that coagulation factors are enriched in macropores. The chitosan hydrogel provides a positively charged surface, accelerates the enrichment rate of coagulation factors, and further acceleratesthe coagulation reaction. And the material has good biocompatibility, and can be used in animal models of rat femoral artery trauma for effective hemostasis. The hemostatic material can be made intopowder or added into fabric to make tourniquet, hemostatic sponge and other forms, and is suitable for complex wounds. The hemostatic process does not exothermic has higher safety, and the hemostaticmaterial can still retain efficacy after moisture absorption, and is convenient for long-term storage.

Description

technical field [0001] The invention belongs to the field of hemostatic materials, and more specifically relates to a composite hemostatic material for trauma and a preparation method thereof. Background technique [0002] Acute blood loss is the rapid and massive loss of blood in a short period of time due to the rupture of blood vessels caused by trauma, or the coagulation and hemostasis dysfunction caused by diseases. Acute blood loss accounts for the vast majority of deaths from trauma. According to the statistics of the U.S. military, more than 80% of the number of deaths due to war injuries on the battlefield in 2001-2011 was caused by excessive blood loss. In addition, the frequent occurrence of traffic accidents, typhoons, earthquakes and other natural disasters in recent years is also an important reason for the increase in acute blood loss deaths. Therefore, the development of rapid and efficient hemostatic agents for external trauma has special practical value, ...

Claims

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Application Information

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IPC IPC(8): A61L15/42A61L15/18A61L15/28
CPCA61L15/18A61L15/28A61L15/42A61L15/425A61L2400/04C08L5/08C08L5/04C08L5/12
Inventor 赵灵之彭娟娟
Owner CHINA PHARM UNIV
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