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Longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions

An extract, the technology of longan flower, applied in the application field of longan flower extract, can solve the problems of little inhibition of melanin, no whitening, anti-aging, cytotoxicity, etc.

Active Publication Date: 2019-01-29
CHIA NAN UNIV PHARMACY & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Most of the literature points out that longan flower has anti-oxidation and anti-inflammation effects, but there are few related studies on the activity of inhibiting melanin synthesis and DNA repair, and there is no discovery of its whitening and anti-aging functions. Contains whitening ingredients such as: vitamin C (Vitamin C), hydroquinone (Hydroquinone), azaleaic acid (Acelaic acid) and arbutin (Arbutin), although they have significant effects, but some whitening agents have the effect of directly destroying melanocytes , thus causing cytotoxicity

Method used

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  • Longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions
  • Longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions
  • Longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1: the water extraction of longan flower

[0040] Longan flowers were purchased from the Farmers Association of Zhongliao Township, Nantou County. After pounding the longan flower, take 100 grams of the pounded extract and 900 grams of water and mix them in a round-bottomed flask with double grinding mouths. Then, put in a heating bag and mix the extract and water under reflux at 80 to 90° C. for about 3 hours. After the time is up, the round-bottomed flask with double grinding mouths is cooled, and then the mixture is filtered with a Buchner funnel and an air pump to obtain a clear filtrate. Finally, first concentrate the filtrate under reduced pressure, then freeze the concentrated filtrate for about one day at -80°C, and then freeze-dry it in a vacuum bottle to obtain the final product water extract DLFW (extraction rate is about 7.2%, 100 grams of longan flower 7.2 g of aqueous extract (DLFW) were obtained. It should be noted that before carrying out sub...

Embodiment 2

[0041] Embodiment 2: the ethanol extraction of longan flower

[0042] Longan flowers were purchased from the Farmers Association of Zhongliao Township, Nantou County. After pounding the longan flower, take 100 grams of pounded extract and soak in 500 grams of 95% ethanol for three days. Then, the mixture was filtered with a Buchner funnel and an aspirator to obtain a clear filtrate. In addition, the filtered residue was soaked in 500 g of 95% ethanol for three days, and the mixture was filtered with a Buchner funnel and an air pump to obtain a clear filtrate. Finally, after mixing the two obtained filtrates, first concentrate the filtrate under reduced pressure, then freeze the concentrated filtrate at -80°C for about one day, and then freeze-dry it in a vacuum bottle to obtain the final product ethanol extract DLFE (extraction The rate is about 6.0%, and 100 grams of longan flowers can obtain 6.0 grams of ethanol extract (DLFE). It should be noted that before carrying out ...

Embodiment 3

[0043] Example 3: Cytotoxicity Rational Test

[0044] In view of the fact that the existing whitening agents or skin melanin inhibitors can cause cytotoxicity, the inventor first carried out the cytotoxicity test of this compound after obtaining the longan flower extract, using 100, 250 and 500 μg / mL After the concentration of longan flower extract acted on HaCaT cells for 24 hours, the viability was determined by MTT assay. The result is as figure 1 It has been shown that the water-extracted DLF and the ethanol-extracted DLFE of longan flower are not toxic in cells, and are safer than ascorbic acid (AA), which is commonly used in the market.

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PUM

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Abstract

The invention relates to a longan flower extract with anti-aging, whitening, anti-allergic and cell repair functions, and the invention applies an effective dose of longan flower extract to skin cells, which has the functions of scavenging DPPH. and ABTS.+ free radicals, reducing power, chelation of iron ions and inhibiting lipid peroxide performance; inhibiting tyrosinase activity; removing nitric oxide (NO) free radicals, inhibition of lipoxygenase 1 (LOX-1) activity; inhibiting hyaluronic acid capacity, increase skin hyaluronic acid content, promoting wound repair, and reducing wrinkles production; inhibiting matrix metalloproteinases (MMPs) activity, and reducing collagen degradation; promoting cell repair ability and improving anti-allergic ability and other mechanisms.

Description

technical field [0001] The present invention relates to the application of a longan flower extract, especially the use of the longan flower extract as an additive for cosmetics, skin care products and other skin care products to achieve anti-aging, anti-oxidation, anti-inflammation, inhibition of melanin, anti-wrinkle, The purpose of anti-allergic and cell repair mechanisms. Background technique [0002] Modern orientals have increasing demands for clear skin and also attach importance to health. Therefore, how to propose a healthy way to lighten spots is a development focus for the external medicine industry. For beauty and maintenance, traditional plants are mostly warming and tonic medicines for invigorating qi, promoting blood circulation, and adjusting physical fitness. There are also a few single and compound prescriptions that are directly used for skin whitening, acne removal, and anti-inflammatory purposes. However, the mechanism analysis of active ingredients in p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61K36/77A61Q19/02A61Q19/08A61Q19/00A61P17/18A61P29/00A61P17/16A61P37/08A23L33/105A61K133/00
CPCA61P17/16A61P17/18A61P29/00A61P37/08A61Q19/00A61Q19/02A61Q19/08A23L33/105A61K8/9789A61K36/77A23V2002/00A61K2800/782A61K2800/805A61K2800/84A23V2200/30A23V2200/318A23V2250/21
Inventor 梁家华曾良鹏陈品儒张子贤
Owner CHIA NAN UNIV PHARMACY & SCI
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