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Fabrication method of pyridostigmine bromide molecular imprinting electrochemical sensor

A technology of pyridostigmine bromide and molecular imprinting is applied in the field of preparation of molecularly imprinted electrochemical sensors, which can solve the problems of inappropriate matching between functional monomers and template molecules, poor toughness and rigidity of cross-linked membranes, and low sensitivity.

Inactive Publication Date: 2019-02-12
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The current method has low sensitivity and poor drop resistance because the selected functional monomers and template molecules cannot be properly matched, and the toughness and rigidity of the crosslinked film are also poor.

Method used

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  • Fabrication method of pyridostigmine bromide molecular imprinting electrochemical sensor

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Experimental program
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Embodiment 1

[0016] 1. Treatment of glassy carbon electrodes

[0017] The glassy carbon electrode was polished with 1.0 μm, 0.3 μm and 0.05 μm alumina powder on a polishing cloth in turn, then placed in nitric acid with a volume ratio of 1:1 for 8 minutes, and then placed in absolute ethanol for 8 minutes , and finally ultrasonically cleaned with pure water.

[0018] 2. Preparation of molecularly imprinted electrochemical sensor for pyridostigmine bromide

[0019] Prepare 20 mL of a mixed aqueous solution of cobalt sulfate with a concentration of 0.25 mol / L, zinc sulfate with a concentration of 0.25 mol / L and vitamin C with a concentration of 0.5 mol / L using water as a solvent, and prepare a concentration of 0.05 mol with benzyl alcohol as a solvent / L 5 mL of distearyl pentaerythritol diphosphite, and then add 5 mL of distearyl pentaerythritol diphosphite solution dropwise to the 20 mL of cobalt sulfate and zinc sulfate prepared above at a rate of 5 drops / second. and vitamin C mixed so...

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Abstract

The invention discloses a fabrication method of a pyridostigmine bromide molecular imprinting electrochemical sensor. Pyridostigmine bromide is used as a template molecule, pachymic acid is used as afunctional monomer, azobisisobutyronitrile is used as an initiator, a cobalt-zinc layered powder composite material is used as a doping agent, 4-cyclohexanoxy-4'-cyanobiphenyl is used as a sensing film modifying agent, oleuropein is used as a cross-linking agent, and thus, the high-sensitivity and falling-resistant pyridostigmine bromide molecular imprinting electrochemical sensor doped with the cobalt-zinc layered powder composite material is fabricated. The analysis method is simple and practical, and the defects of complexity, equipment expensiveness and low sensitivity of a traditional analysis method are overcome.

Description

technical field [0001] The invention relates to a molecularly imprinted electrochemical sensor, in particular to a preparation method of a pyridostigmine bromide molecularly imprinted electrochemical sensor. Background technique [0002] Pyridostigmine Bromide is mainly used for the treatment of myasthenia gravis, postoperative abdominal distension or urinary retention, and muscle relaxation against non-depolarizing muscle relaxants. However, long-term or excessive use of such drugs can cause side effects such as diarrhea, nausea, vomiting, stomach cramps, increased sweating and saliva, miosis, mental abnormalities, and liver damage caused by drug sensitivity. controlled substances. [0003] The methods for the determination of pyridostigmine bromide include high performance liquid chromatography, chromatography-mass spectrometry, etc. However, due to the need for expensive instruments and equipment, these methods have disadvantages such as high cost, long time-consuming, ...

Claims

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Application Information

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IPC IPC(8): G01N27/327
CPCG01N27/3275
Inventor 谭学才李浩雷福厚韦贻春陈其锋余会成
Owner GUANGXI UNIV FOR NATITIES