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Anti-inflammatory and analgesic external plaster for treatment of various pains

An anti-inflammatory, pain-relieving and plaster technology, which is applied in the direction of non-central analgesics, antipyretics, anti-inflammatory agents, etc., can solve problems such as differences in content and composition, unstable colloid quality, poor aging resistance, etc., and achieve good viscosity , reduce skin allergies, long moisturizing effect

Inactive Publication Date: 2019-02-22
辽宁新高制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, natural rubber also has some problems as a skeleton material: one is that the molecule contains unsaturated double bonds, and the aging resistance is poor; the other is that the molecular weight of rubber and the content and composition of non-rubber molecules will vary due to different places of origin and tree species. , so that the quality of the colloid is unstable; the third is that the trace protein contained in the rubber may cause individual skin allergies

Method used

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  • Anti-inflammatory and analgesic external plaster for treatment of various pains
  • Anti-inflammatory and analgesic external plaster for treatment of various pains

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] An anti-inflammatory and analgesic external plaster for various pain treatments, comprising 4 parts of menthol, 2 parts of camphor, 2 parts of methyl salicylate, 1.5 parts of diphenhydramine hydrochloride, 3 parts of borneol, and 4 parts of eggplant liquid extract, 2 parts of thymol, 30 parts of zinc oxide, 35 parts of rosin, 40 parts of natural rubber, 10 parts of vaseline, 2 parts of lanolin, 1 part of liquid paraffin, N,N'-bis(β- 0.04 parts of naphthyl)-p-phenylenediamine, 0.15 parts of butyl hydroxycresyl.

[0017] It is prepared through the following process steps: first, the natural rubber is masticated to form a silk mesh, after eliminating static electricity and dipping, adding vaseline, lanolin, and liquid paraffin in turn to form a matrix material; crushing borneol, menthol, and camphor, and mixing with water Add methyl sylate and belladonna fluid extract to the base material and mix evenly; add diphenhydramine hydrochloride, zinc oxide, rosin, liquid paraffin...

Embodiment 2

[0019] An anti-inflammatory and analgesic external plaster for various pain treatments, comprising 3 parts of menthol, 4 parts of camphor, 3 parts of methyl salicylate, 1 part of diphenhydramine hydrochloride, 2 parts of borneol, and 3 parts of eggplant liquid extract, 1.5 parts of thymol, 20 parts of zinc oxide, 25 parts of rosin, 35 parts of natural rubber, 8 parts of vaseline, 1.5 parts of lanolin, 0.5 parts of liquid paraffin, N,N'-two (β- 0.02 part of naphthyl)-p-phenylenediamine, 0.1 part of butyl hydroxycresyl.

[0020] The preparation method is the same as in Example 1.

Embodiment 3

[0022] An anti-inflammatory and analgesic external plaster for various pain treatments, comprising 5 parts of menthol, 4 parts of camphor, 4 parts of methyl salicylate, 1.5 parts of diphenhydramine hydrochloride, 3 parts of borneol, and 4 parts of eggplant fluid extract, 2 parts of thymol, 30 parts of zinc oxide, 35 parts of rosin, 45 parts of natural rubber, 9 parts of vaseline, 2.5 parts of lanolin, 1 part of liquid paraffin, N,N'-bis(β- 0.03 part of naphthyl)-p-phenylenediamine, 0.1 part of butyl hydroxycresyl.

[0023] The preparation method is the same as in Example 1.

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Abstract

The invention relates to an anti-inflammatory and analgesic external plaster with natural rubber as a matrix. TheAn anti-inflammatory and analgesic external plaster for treatment of various pains provided by the invention is prepared from the following components: menthol, camphor, methyl salicylate, diphenhydramine hydrochloride, borneol, extractum belladonnae liquidum, thnymol, zinc oxide, rosin, natural rubber, vaseline, lanolin, liquid paraffin, N,N'-bis(beta-naphthyl)-p-phenylenediamine, butylated hydroxytoluene through the steps of rubber plasticating, electrostatic eliminating, gum dipping, plaster making, filtering, stand stilling, plaster feeding, slitting, punching, packaging and the like. According to the anti-inflammatory and analgesic external plaster, through the synergisticeffect of various components of a softener, a tackifier, an antiager and the like, the problems that a natural rubber plaster is prone to aging, a rubber body is instable in quality, and the natural rubber plaster is prone to sensitization are effectively solved; and meanwhile, transdermal absorption is good, irritation is small, the moisturizing period is long, and quick swelling and pain relieving, and blood circulation activating and promoting to remove blood stasis dissolving can be achieved.

Description

technical field [0001] The invention relates to a plaster for external use, in particular to an external plaster for anti-inflammation and analgesic treatment of various pains with natural rubber as the matrix. Background technique [0002] Rubber ointment refers to the plaster made by mixing the matrix composed of drugs and skeleton materials, tackifiers, fillers and softeners, and then coating it on the mounting material. Role of topical and systemic treatments. It is easy to use, has a definite curative effect, and avoids the first-pass effect of oral administration of drugs through the gastrointestinal tract and liver. The rubber ointment delivered by transdermal administration is more stable and directly enters the blood than oral administration. It is convenient to use and painless. It is widely used at present. For rheumatism, angina pectoris, bronchitis and various orthopedic diseases. [0003] The natural rubber structure has many advantages in constituting the pl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61P29/00A61K9/70A61K47/44A61K31/045A61K31/05A61K31/125A61K31/135A61K31/618A61K33/30
CPCA61K9/7076A61K31/045A61K31/05A61K31/125A61K31/135A61K31/618A61K33/30A61K36/81A61P29/00A61K2300/00
Inventor 杨朝辉杨启家齐海峰
Owner 辽宁新高制药有限公司
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