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a kind of moo 2 -icg multifunctional nanoparticle and its preparation method and application

A nanoparticle and multifunctional technology, applied in the field of MoO2-ICG multifunctional nanoparticle and its preparation, can solve the problems of decreased body function of patients, large toxic and side effects, inability to effectively cure tumors, etc., and achieve high-efficiency tumor killing and low price. , The effect of good dispersion stability

Active Publication Date: 2021-06-25
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These three methods have their own disadvantages. They cannot effectively cure the tumor and inhibit the recurrence of cancer, and are often accompanied by relatively large toxic and side effects, resulting in a sharp decline in the patient's body function.

Method used

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  • a kind of moo <sub>2</sub> -icg multifunctional nanoparticle and its preparation method and application
  • a kind of moo <sub>2</sub> -icg multifunctional nanoparticle and its preparation method and application
  • a kind of moo <sub>2</sub> -icg multifunctional nanoparticle and its preparation method and application

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Experimental program
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Embodiment 1

[0031] Weigh 0.2mmol ammonium molybdate (0.2472g) and dissolve it in 20mL water, mix with 10mL PVP aqueous solution (0.1g / mL), add 3mL ethylene glycol, and stir at room temperature for 10 minutes to obtain a clear and transparent solution. The resulting solution was then transferred to a 50 mL volume stainless steel reaction vessel and sealed. Put the reaction kettle in an oven at 200°C for 60 hours, cool it down to room temperature, take it out, centrifuge at 10,000rpm to separate the reaction product, and wash it with 75% acetone aqueous solution for 3 times, distilled water for 2 times, and get MoO after centrifugation 2 nanoparticles.

[0032] figure 1 (a, b) are respectively MoO 2 SEM and TEM images of nanoparticles, it can be seen that MoO 2 The size of nanoparticles is relatively uniform, about 100nm, figure 1 Clear lattice fringes can be seen in the high-resolution image in (b), and the lattice spacing is 0.343nm corresponding to monoclinic MoO 2 phase (-111) crys...

Embodiment 2

[0035] By pairing the synthesized MoO 2 Nanoparticles are modified on the surface to improve the loading efficiency and loading capacity of ICG molecules on the particles. A certain amount of MoO 2 Nanoparticles were formulated at a concentration of 1mg / mL, PEI-25000 molecules were added to make the concentration of PEI 2mg / mL, stirred at room temperature for 4 hours, centrifuged, and dispersed in aqueous solution again, in a gradient concentration of ICG solution (20-400μg / mL) MoO 2 - PEI nanoparticles, after being stirred in the dark for 24 hours, centrifuged and washed several times until the supernatant is colorless and transparent. The centrifugal speed is 10000rpm, and the washing is performed by water: acetone volume ratio of 1:3 solution and distilled water.

[0036] image 3 (d) is the exploration of the loading amount under different ICG concentrations. It can be seen that with the increase of ICG concentration, the absorption peak intensity of the UV curve at 780...

Embodiment 3

[0040] Will MoO 2 Nanoparticles and MoO 2 - The ICG nanoparticles were configured into aqueous solutions of different concentrations and placed in a 24-well plate with a concentration gradient of 10, 20, 50, 100, and 200 μg / mL, and deionized water was used as a control. With 808nm laser (power density 0.8W / cm 2 ) to irradiate the aqueous solutions of different samples, and record the temperature changes with an infrared thermal imager at different irradiation times. Figure 4 (a) shows MoO 2 - Thermal imaging photos of ICG nanoparticles at different concentrations and at different times. Figure 4 (b, c) are respectively MoO 2 Nanoparticles and MoO 2 -Curve of temperature of ICG nanoparticles as a function of irradiation time.

[0041] From Figure 4 (b) It can be seen that under the irradiation of 808nm laser for 5 minutes, the temperature rise of water is only 1°C, which is negligible. 2 The nanoparticle solution can rise 10°C, 14.2°C, 23.7°C, 31.2°C, 35.3°C respecti...

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Abstract

The present invention relates to a kind of MoO 2 ‐ICG multifunctional nanoparticles and its preparation method and application, wherein the preparation method includes photothermal agent MoO 2 Synthesis and preparation of nanoparticles, modification of surface PEI molecules, and loading of photosensitizer ICG. MoO in the present invention 2 The nanoparticle synthesis method is simple, the size is uniform, the dispersion in water is good, the ICG water solubility is good, the loading capacity is high, and it responds in the NIR region. It can realize tumor phototherapy under 808nm laser irradiation, and realize photothermal and photodynamic synergistic therapy. In order to achieve better tumor treatment effect.

Description

technical field [0001] The invention belongs to the field of biological nanomaterials and relates to a kind of MoO 2 -ICG multifunctional nanoparticles and its preparation method and application. Specifically, the present invention relates to the preparation and application performance evaluation of a nano-platform for photothermal-photodynamic therapy of tumors with photothermal and photodynamic functions. Background technique [0002] Cancer is one of the diseases with the highest disappointment rate in the world, and its morbidity and mortality are on the rise. The spread and metastasis of the tumor is the reason for such a high mortality rate and low cure rate. Traditional tumor treatment methods include surgery, radiotherapy and chemotherapy. These three methods have their own disadvantages, they cannot effectively cure the tumor and inhibit the recurrence of the cancer, and are often accompanied by relatively large toxic and side effects, resulting in a sharp declin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61P35/00A61P35/04
CPCA61K9/5146A61K41/0052A61K41/0057A61P35/00A61P35/04A61K2300/00
Inventor 李翔方超韩高荣
Owner ZHEJIANG UNIV
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