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Cosmetic composition for relieving skin irritation and relieving skin inflammation comprising hydrangea fermented product

A cosmetic composition, a technology for skin inflammation, applied in the directions of medical preparations, cosmetics, cosmetic preparations containing active ingredients, etc., can solve the problems of skin irritation relief and skin inflammation relief effects of unrecorded hydrangea fermented extract, and achieve Soothing skin irritation and skin inflammation

Active Publication Date: 2020-10-30
COSMAX INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, none of the aforementioned cosmetic compositions describe the skin irritation-relieving and skin-inflammation-relieving effects of the hydrangea fermented extract of the present invention.

Method used

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  • Cosmetic composition for relieving skin irritation and relieving skin inflammation comprising hydrangea fermented product
  • Cosmetic composition for relieving skin irritation and relieving skin inflammation comprising hydrangea fermented product
  • Cosmetic composition for relieving skin irritation and relieving skin inflammation comprising hydrangea fermented product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: the preparation of hydrangea extract

[0034] After the hydrangea was powdered, 100 g of each extract was placed in a separate container, immersed in 1 L of 70% by weight ethanol aqueous solution as an extraction solvent, and left at room temperature for 24 hours to obtain an extract. After filtering the obtained extract with filter paper, the filtrate was concentrated under reduced pressure using a rotary evaporator to obtain an extract.

Embodiment 2

[0035] Embodiment 2: the preparation of Hydrangea fermented product

[0036] The hydrangea fermented product is prepared by fermenting the hydrangea extract obtained in the above-mentioned Example 1 by using pear flower koji. The present invention is characterized in that the pear flower koji uses two kinds of inoculum, namely, koji culture and yeast liquid culture.

[0037] Koji culture refers to a solid culture (Koji) that is inoculated with Aspergillus oryzae after sterilizing rice adjusted to a water content of 38-42% at 121°C for 30 minutes, and then dried. Yeast liquid culture (Saccharomyces cerevisiae) refers to a culture in which yeast is cultured in a potato dextrose liquid medium.

[0038] The pear flower koji of the present invention is produced by the following method. First, at a temperature of 60° C., 100 parts by weight of washed rice are dried for 20 to 24 hours, and then pulverized. The powder that has passed through a sieve of about 40 meshes is recovered...

experiment example 1

[0040] Experimental example 1: Evaluation of anti-inflammatory efficacy

[0041] In order to evaluate the anti-inflammatory effect of the fermented extract, IL-1β, IL-6, and IL-8, which are inflammation-inducing cytokines, were treated with fine dust (PM10), and their expression levels were measured. More specifically, HaCaT cells, which are keratinocytes, were treated with fine dust so that the final concentration of each raw material prepared in Example 1 and Example 2 was 10 μg / ml, and cultured for 4 hours. Next, mRNA was extracted in cells, synthesized as cDNA, and real-time polymerase chain reaction (PCR) was performed using a target template (primer), thereby finally evaluating the degree of gene expression of inflammatory cytokines. The results are shown in Figure 1 ~ Figure 3 middle.

[0042] As a result, such as Figure 1 ~ Figure 3 As shown, when the respective cytokines were induced by fine dust, the degree of inhibition of the hydrangea extract and the hydran...

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PUM

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Abstract

The present invention relates to a cosmetic composition containing a Hydrangea macrophylla fermented product as an active ingredient for soothing skin irritation and skin inflammation. According to the present invention, the cosmetic composition containing a Hydrangea macrophylla fermented product as an active ingredient according to the present invention soothes skin irritation and skin inflammation by inhibiting the expression of inflammation-induced cytokines (IL-6, IL-8, and IL-Ιβ), and thus, ultimately, the cosmetic composition can be effectively applied for use in the prevention and alleviation of skin problems, mitigation of flush, prevention and alleviation of dermatitis, and the like.

Description

technical field [0001] The present invention relates to a cosmetic composition for alleviating skin inflammation, and more specifically, to a cosmetic composition for alleviating skin irritation and alleviating skin inflammation comprising a hydrangea fermented product. Background technique [0002] One of the most important functions of the skin is its protective function as a barrier. The skin, which is directly exposed to the external environment, is the most important first line of defense against loss of body fluids and protecting the body from harmful environments. And, it performs a barrier function against toxic substances or microorganisms, physical stimuli, or ultraviolet rays. However, when this skin barrier function is subjected to various external and internal stimuli of the skin, the skin barrier is damaged, resulting in dryness of the skin or inflammation of the skin. At the same time, if the initial inflammatory reaction that occurs at this time cannot be e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/02A61Q19/00
CPCA61K8/02A61K8/97A61Q19/00A61K8/022A61K8/06A61K2800/85A61K8/9789
Inventor 李敬银柳正镇姜承贤金延俊
Owner COSMAX INC
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