Preparation method of novel hydrophilic fat-soluble vitamin microcapsules

A technology of fat-soluble vitamins and microcapsules, which is applied in the direction of adding food elements, resisting vector-borne diseases, forming or processing animal feed, etc., and can solve the problems of animal protein glue, such as high safety hazards, difficult processes, and low efficiency. , to achieve the effect of high microencapsulation yield, wide application range and good fluidity

Active Publication Date: 2019-03-05
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After the emulsion is cross-linked, it is usually accompanied by an increase in viscosity, which will affect the spray drying effect without adding additional water. The process is difficult and the efficiency is low.
[0014] The water-insoluble effects of the microcapsules described in the above-mentioned patents CN103549157 (B) and CN105433373 (A) are all achieved by cross-linking animal protein glue, and the water-insoluble effect is better, but the animal protein glue has great potential safety hazards and the market is unstable
The water-insoluble effect of the microcapsules described in the patent CN102716087 (B) is achieved by cross-linking of plant glue, the process is difficult, the efficiency is low, and the water-insoluble effect of the obtained product is relatively poor

Method used

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  • Preparation method of novel hydrophilic fat-soluble vitamin microcapsules
  • Preparation method of novel hydrophilic fat-soluble vitamin microcapsules
  • Preparation method of novel hydrophilic fat-soluble vitamin microcapsules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Under the protection of nitrogen, crystallize 130 grams of vitamin A and melt 8 grams of BHT at 75°C to make vitamin A melt oil. 95 grams of sodium starch octenyl succinate (Lyckeby PU 41032 produced by Lyckeby starch in Sweden) and 39 grams of glucose were dissolved in 180 grams of 60° C. water to form a 43% starch glucose aqueous solution. Wherein, preferably before "being made into 43% starch glucose aqueous phase solution", the aqueous solution of sodium starch octenyl succinate was boiled separately at 80° C. for 10 minutes.

[0039] Under the condition of high-speed shearing, the melted vitamin A oil is poured into the above-mentioned aqueous phase solution for emulsification and homogenization to obtain a stable emulsion. The emulsion was fully mixed with 5 grams of sodium hexametaphosphate, then sent into a starch bed for spray granulation, then fluidized and dried, and cross-linked at a high temperature of 110°C to obtain 318 grams of water-repellent vitamin A ...

Embodiment 3

[0044] Under the protection of nitrogen, 40 grams of vitamin A crystals and 5 grams of TBHQ were melted at 75°C to make vitamin A melt oil. 56 grams of sodium starch octenyl succinate (N912 produced by National Starch), and 50 grams of glucose were dissolved in 110 grams of 60°C water to form a 49% starch glucose aqueous phase solution. Wherein, preferably before "being made into 49% starch glucose aqueous phase solution", the aqueous solution of sodium starch octenyl succinate was boiled separately at 75°C for 15 minutes.

[0045] Under the condition of high-speed shearing, the melted vitamin A oil is poured into the above-mentioned aqueous phase solution for emulsification and homogenization to obtain a stable emulsion. The emulsion was fully mixed with 3 grams of potassium dihydrogen phosphate, then sent into a starch bed for spray granulation, then fluidized and dried, and cross-linked at a high temperature of 120°C to obtain 183 grams of water-repellent vitamin A microcap...

Embodiment 5

[0055] Under nitrogen protection, crystallize 20 grams of vitamin D3 and melt 2.5 grams of tocopherol at 75°C to prepare vitamin D3 melted oil. Dissolve 50 grams of sodium starch octenyl succinate (N912 produced by National Starch), and 100 grams of fructose in 160 grams of 65° C. water to form a 48% starch-fructose aqueous phase solution. Wherein, preferably before "being made into 48% starch glucose aqueous phase solution", the aqueous solution of starch sodium octenyl succinate was boiled separately at 75°C for 20 minutes.

[0056] Under the condition of high-speed shearing, the melted vitamin D3 oil is poured into the above water phase solution for emulsification and homogenization to obtain a stable emulsion. The emulsion was fully mixed with 3 grams of sodium dihydrogen phosphate, and then sent into a starch bed for spray granulation, then fluidized and dried, and cross-linked at a high temperature of 100°C to obtain 242 grams of vitamin D3 microcapsules. The microcapsu...

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Abstract

The invention provides a preparation method of novel hydrophilic fat-soluble vitamin microcapsules. Different from a conventional protein (gelatin) microencapsulated cross-linking coating technique, amicroencapsulated cross-linking coating technique adopted by the preparation method disclosed by the invention lies in that fat-soluble vitamin oil is dispersed in a sodium starch octenyl succinate-reducing sugar coating substrate in a micro dropping manner, and then a new processing technology is adopted for enabling sodium starch octenyl succinate to react with reducing sugar, so that cross-linking coated granules being interlaced in vertical and horizontal directions, airtight and watertight, are formed; and a solid protection layer is formed on the surfaces of the microcapsules, so that the destroying of chemistry, high temperature, high humidity and machinery for fat-soluble vitamins can be resisted to the maximum extent.

Description

technical field [0001] The invention relates to the technical field of feed additives, in particular to a preparation method of a novel water-repellent fat-soluble vitamin microcapsule. Background technique [0002] Vitamins are necessary for animal nutrition and growth, and play an extremely important role in the metabolism, growth, development and health of the body. If there is a long-term lack of certain vitamins, it will cause physiological dysfunction and certain diseases. Vitamins are a huge family. There are dozens of known vitamins, which can be roughly divided into two categories: fat-soluble and water-soluble. Fat-soluble vitamins include vitamin A, vitamin D3, vitamin E, and vitamin K. Vitamin A has the functions of maintaining normal visual function of the human body, maintaining the health of epithelial tissue cells, maintaining normal growth and development of bones, and promoting growth and reproduction. Vitamin D3 can enhance the body's ability to absorb c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/174A23K40/30
CPCA23K20/174A23K40/30Y02A50/30
Inventor 朱宏铭李春毛国泉朱舒燕王琴兰李小辉邢健军
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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