A kind of madecassoside liposome and its preparation method and application

A technology of madecassoside and oxaloside is applied in the field of madecassoside liposome and its preparation, and can solve the problems of incapability of multi-effect synergy, dermis layer affecting the use effect, unsuitable for large-area treatment and the like , to achieve the effect of promoting cell metabolism and cell regeneration, avoiding excessive proliferation and accelerating wound healing

Active Publication Date: 2021-09-07
广州市晨茜化工有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Common methods to eliminate stretch marks include: ① skin peeling method: using chemical peeling agents, which is easy to cause adverse reactions, resulting in thinning of the stratum corneum and skin sensitivity; The requirements are high, and the effect is not obvious; ③Laser therapy: this method is not suitable for large-scale treatment, and it is easy to cause skin sensitivity; ④Abrasion method: the physical grinding process of the skin is painful and easily causes skin damage
[0004] The currently marketed anti-pregnancy products have a single effect and cannot work synergistically with multiple effects, and it is difficult to reach the dermis of the skin, which affects the effect of use
Although madecassoside has the effects of scar repair, antibacterial, anti-inflammation, and promotion of fibroblast regeneration, it is difficult to penetrate the skin due to its polar macromolecules, and the external treatment effect is poor

Method used

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  • A kind of madecassoside liposome and its preparation method and application
  • A kind of madecassoside liposome and its preparation method and application
  • A kind of madecassoside liposome and its preparation method and application

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preparation example Construction

[0031] The present invention provides a preparation method of the above-mentioned madecassoside liposome, comprising the following steps:

[0032] (1) Preparation of oil phase: Melt phospholipids, cholesterol, and ceramide in a water bath at a temperature of 65-80°C, then add antioxidants, mix well, and set aside;

[0033] (2) Prepare the water phase: add madecassoside, polyol, and collagen into the purified water of the formula, stir and heat at 65-80°C to dissolve madecassoside, collagen, and polyol, and set aside;

[0034] (3) Preparation of colostrum: Add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) with constant stirring, and then emulsify at a high speed of 10,000 rpm for 2 min to obtain colostrum;

[0035] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70°C, and then process it through high-pressure homogenization equipment with a pressure of 500 bar to 1500 bar and a cycle of 2 to 8 times. Cool down to 5...

Embodiment 1

[0040] (1) Preparation of oil phase: Melt 3.0% soybean lecithin, 0.5% cholesterol, and 0.05% ceramide Ⅰ in a water bath at 65-80°C, then add 2.0% α-tocopherol, mix well, and set aside;

[0041] (2) Preparation of water phase: Add 0.1% madecassoside, 10.0% propylene glycol, 0.2% deep-sea cod skin collagen, 0.3% coconut collagen into 82.25% purified water, stir and heat at 65-80°C to dissolve ,spare;

[0042] (3) Preparation of colostrum: Add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) with constant stirring, and then emulsify at a high speed of 10,000 rpm for 2 min to obtain colostrum;

[0043] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70°C, and then process it through high-pressure homogenization equipment with a pressure of 500 bar and 3 cycles, and cool down to 50°C;

[0044] (5) Add 0.4% rose essential oil, 0.1% shea oil, 0.1% fibroblast growth factor, and 1.0% honeysuckle extract to (4), stir evenly, 8...

Embodiment 2

[0046] (1) Preparation of oil phase: Melt 1.0% phosphatidylcholine, 2.0% egg yolk lecithin, 5% cholesterol, and 0.1% ceramide II in a water bath at 65-80°C, then add 1.5% α-tocopherol and mix well ,spare;

[0047] (2) Preparation of water phase: Add 5% madecassoside, 10.0% propylene glycol, 5.0% 1,3-butanediol, 0.5% deep sea cod skin collagen, 0.5% coconut collagen to 68.3% purified water , stir and heat at 65-80°C to dissolve, set aside;

[0048] (3) Preparation of colostrum: Add the oil phase prepared in step (1) dropwise to the water phase prepared in step (2) with constant stirring, and then emulsify at a high speed of 10,000 rpm for 2 min to obtain colostrum;

[0049] (4) Preparation of liposomes: heat the colostrum prepared in step (3) at 70°C, and then process it through high-pressure homogenization equipment at a pressure of 1000 bar, with 2 cycles, and cool down to 50°C;

[0050] (5) Add 0.1% carrot seed oil, 0.5% olive oil, and 0.1% fibroblast growth factor to (4),...

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Abstract

The invention relates to a madecassoside liposome and its preparation method and application. The madecassoside liposome consists of 0.1%-8.0% madecassoside, 3.0%-10.0% madecassoside % phospholipids, 0.5% to 5.0% cholesterol, 0.05% to 1.0% ceramide, 0.5% to 2.0% plant essential oils, 10.0% to 25.0% polyols, 0.5% to 2.0% antioxidants, 0.5% to 5.0% collagen, 0.1%-1.0% fibroblast growth factor, 0.5%-2.0% honeysuckle extract and the rest water. The madecassoside liposome prepared by the invention can promote the penetration of madecassoside into the skin and play a long-term effect, and each component can play a synergistic effect, promote the regeneration of fibroblasts, regulate the skin, increase skin elasticity and moisture , Eliminate free radicals, replenish collagen, achieve cell regeneration, increase skin elasticity, and remove stretch marks.

Description

technical field [0001] The invention belongs to the technical field of cosmeceuticals, and in particular relates to a madecassoside liposome and a preparation method and application thereof. Background technique [0002] The formation of stretch marks is mainly due to the influence of hormones during pregnancy. The swelling of the abdomen causes the elastic fibers and collagen fibers of the skin to be damaged or broken to varying degrees due to external force. The skin becomes thinner and thinner, and the abdominal wall skin appears different in width and length. Stretch marks are usually pink or purple wavy streaks; after childbirth, these streaks will gradually disappear, leaving white or silvery white shiny scar lines, that is stretch marks. [0003] Common methods to eliminate stretch marks include: ① skin peeling method: using chemical peeling agents, which is easy to cause adverse reactions, resulting in thinning of the stratum corneum and skin sensitivity; The requir...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/14A61K8/34A61K8/42A61K8/55A61K8/63A61K8/64A61K8/65A61K8/92A61K8/9789A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/14A61K8/345A61K8/42A61K8/553A61K8/63A61K8/64A61K8/65A61K8/922A61Q19/00A61Q19/02A61Q19/08A61K8/9789
Inventor 胡克
Owner 广州市晨茜化工有限公司
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