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Medical material for inducing tissue repair as well as preparation method and application thereof

A technology for tissue repair and loading materials, which is applied in the field of medical materials, and can solve problems such as the inability to provide surface cells on materials, the non-specificity of intervening scaffold materials, and the selective growth microenvironment

Active Publication Date: 2019-03-08
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The interventional stent materials currently used clinically are often not specific, and the implanted damage site is in urgent need of rapid repair due to the constantly changing external environment, and due to its own material defects and pathological conditions, it cannot provide a selective growth of cells on the surface of the material. microenvironment

Method used

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  • Medical material for inducing tissue repair as well as preparation method and application thereof
  • Medical material for inducing tissue repair as well as preparation method and application thereof
  • Medical material for inducing tissue repair as well as preparation method and application thereof

Examples

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preparation example Construction

[0024] An embodiment of the present invention provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0025] S1. Depositing a polydopamine coating on the material to be loaded

[0026] Specifically, the preparation process of the material to be loaded with the polydopamine coating deposited includes: immersing the material to be loaded in a mixed solution formed of trishydroxymethylaminomethane and dopamine for 6-12 hours. Dopamine can be mixed with high-concentration tris to undergo self-polymerization and form a coating on the surface of the material. The concentration of Tris can be 1-2 mg / mL, and the concentration of dopamine can be 1-3 mg / mL.

[0027] What needs to be added is that the operation of depositing the polydopamine coating on the material can be selected according to the needs. If the material that has already deposited the polydopamine coating is directly used, this step will not be performed.

[0...

Embodiment 1

[0046] This embodiment provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0047] First, mix 1 mg / mL tris solution with an equal volume of 1 mg / mL dopamine solution to form a mixed solution, place a 316L stainless steel plate in the mixed solution for 6 hours, wash it with water three times, and then dry it at 37°C spare.

[0048] Secondly, 0.0005mmol / L zinc chloride solution was added dropwise to a polylysine solution with a concentration of 0.3mg / mL and a weight-average molecular weight of 150KDa, and stirred for 2h; then, under the condition of magnetic stirring, after the reaction, Add 5 mg / mL sodium heparin dropwise to the mixed solution to obtain nanoparticle suspension and react at room temperature for 2 hours, wherein the volume ratio of zinc chloride solution, polylysine solution and sodium heparin solution is about 1:0.9:1.8 .

[0049] Finally, the stainless steel plate with the polydopamine coating d...

Embodiment 2

[0051] This embodiment provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0052] First, mix a 2mg / mL tris solution with an equal volume of a 3mg / mL dopamine solution to form a mixed solution, place a 316L stainless steel plate in the mixed solution for 12 hours, wash it with water three times, and then dry it at 37°C spare.

[0053] Next, add 10mmol / L zinc chloride solution dropwise into polylysine solution with a concentration of 1.0mg / mL and a weight-average molecular weight of 300KDa, and stir for 3h; Add 10 mg / mL heparin sodium dropwise to the solution and react at room temperature for 3 hours, wherein the volume ratio of the zinc chloride solution, polylysine solution and heparin sodium solution is about 1:1.1:2.2.

[0054] Finally, the stainless steel plate with the polydopamine coating deposited on the surface was soaked in the nanoparticle suspension, shaken and reacted at room temperature for 24 hours,...

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Abstract

The invention discloses a medical material for inducing tissue repair as well as a preparation method and application thereof, and relates to the technical field of a medical material. The preparationmethod of the medical material for inducing tissue repair comprises the following steps that a zinc salt solution and a polylysine solution are mixed; then, the mixed solution and a heparinate solution are mixed to obtain nanoparticle turbid liquid; materials to be loaded deposited with a polydopamine coating are soaked in the nanoparticle turbid liquid. For the medical material for inducing tissue repair, nanoparticles with zinc ions are loaded on the materials to be loaded with the polydopamine coating; the formed material has an anticoagulating effect; the cell viability of endothelial cells and smooth muscle cells can be improved. The medical material can be applied to the preparation of intravascular stents; the prepared intravascular stents can promote the proliferation of the endothelial cells and the smooth muscle cells; the problem of artery restenosis in the material implantation later period and very late period is avoided.

Description

technical field [0001] The invention relates to the technical field of medical materials, and in particular to a medical material for inducing tissue repair, its preparation method and application. Background technique [0002] After developing and designing several generations of cardiovascular materials, there are still problems in late and very late arterial restenosis after material implantation. It is often necessary to promote the growth of surface cells on the surface of the product in the early stage, and to design anti-stenosis in the late and very late arteries to ensure the adaptability of the implanted material in the service environment. At the same time, it has an inert or even proliferative effect on smooth muscle cells to reduce the late stage and the emergence of very late arterial restenosis. [0003] The interventional stent materials currently used clinically are often not specific, and the implanted damage site is in urgent need of rapid repair due to t...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L33/10
CPCA61L31/088A61L31/10A61L31/14A61L33/08A61L2300/412A61L2300/416A61L2300/418A61L2300/42A61L2300/602A61L2400/12A61L2400/18A61L2420/02A61L2420/04A61L2420/06A61L2420/08C08L77/04C08L5/10C08L79/02
Inventor 陈俊英曾峥谢银红李霞李莉谭建英王焕然魏来翁亚军黄楠
Owner SOUTHWEST JIAOTONG UNIV
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