Medical material for inducing tissue repair as well as preparation method and application thereof

A technology for tissue repair and loading materials, which is applied in the field of medical materials, and can solve problems such as the inability to provide surface cells on materials, the non-specificity of intervening scaffold materials, and the selective growth microenvironment

Active Publication Date: 2019-03-08
SOUTHWEST JIAOTONG UNIV
View PDF4 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The interventional stent materials currently used clinically are often not specific, and the implanted damage site is in urgent need of rapid repair due to the constantly changi

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medical material for inducing tissue repair as well as preparation method and application thereof
  • Medical material for inducing tissue repair as well as preparation method and application thereof
  • Medical material for inducing tissue repair as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0024] The embodiment of the present invention provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0025] S1, deposit a polydopamine coating on the material to be loaded

[0026] Specifically, the preparation process of the material to be supported on which the polydopamine coating is deposited includes: soaking the material to be supported in a mixed solution formed by tris and dopamine for 6-12 hours. Dopamine can be mixed with high concentration of tris(hydroxymethyl)aminomethane to auto-polymerize and form a coating on the surface of the material. The concentration of tris(hydroxymethyl)aminomethane may be 1-2 mg / mL, and the concentration of dopamine may be 1-3 mg / mL.

[0027] It needs to be supplemented that the operation of depositing a polydopamine coating on the material can be selected according to needs, such as directly using a material that has been deposited with a polydopamine coating, this step will not ...

Example Embodiment

[0045] Example 1

[0046] This embodiment provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0047] First, mix the 1 mg / mL tris solution with the equal volume of 1 mg / mL dopamine solution to form a mixed solution. The 316L stainless steel plate is allowed to stand in the mixed solution for 6 hours, and dried at 37°C after three washings spare.

[0048] Secondly, add 0.0005mmol / L zinc chloride solution dropwise to the polylysine solution with a concentration of 0.3mg / mL and a weight average molecular weight of 150KDa, and stir for 2h; then, under the condition of magnetic stirring, the reaction Add 5mg / mL heparin sodium dropwise to the mixed solution to obtain a nanoparticle suspension and react for 2h at room temperature. The volume ratio of zinc chloride solution, polylysine solution and heparin sodium solution is about 1:0.9:1.8 .

[0049] Finally, the stainless steel plate with the polydopamine coating deposited on...

Example Embodiment

[0050] Example 2

[0051] This embodiment provides a method for preparing a medical material for inducing tissue repair, which includes the following steps:

[0052] First, mix the 2mg / mL tris solution with the equal volume of 3mg / mL dopamine solution to form a mixed solution. The 316L stainless steel plate is allowed to stand in the mixed solution for 12h, and it is dried at 37℃ after three washings. spare.

[0053] Next, add 10mmol / L zinc chloride solution dropwise to the polylysine solution with a concentration of 1.0mg / mL and a weight average molecular weight of 300KDa, and stir for 3h; then under the condition of magnetic stirring, the mixture after the reaction Add 10 mg / mL heparin sodium dropwise to the solution and react for 3 hours at room temperature. The volume ratio of zinc chloride solution, polylysine solution and heparin sodium solution is about 1:1.1:2.2.

[0054] Finally, the stainless steel plate with the polydopamine coating deposited on the surface is soaked in th...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Concentrationaaaaaaaaaa
Concentrationaaaaaaaaaa
Login to view more

Abstract

The invention discloses a medical material for inducing tissue repair as well as a preparation method and application thereof, and relates to the technical field of a medical material. The preparationmethod of the medical material for inducing tissue repair comprises the following steps that a zinc salt solution and a polylysine solution are mixed; then, the mixed solution and a heparinate solution are mixed to obtain nanoparticle turbid liquid; materials to be loaded deposited with a polydopamine coating are soaked in the nanoparticle turbid liquid. For the medical material for inducing tissue repair, nanoparticles with zinc ions are loaded on the materials to be loaded with the polydopamine coating; the formed material has an anticoagulating effect; the cell viability of endothelial cells and smooth muscle cells can be improved. The medical material can be applied to the preparation of intravascular stents; the prepared intravascular stents can promote the proliferation of the endothelial cells and the smooth muscle cells; the problem of artery restenosis in the material implantation later period and very late period is avoided.

Description

technical field [0001] The invention relates to the technical field of medical materials, and in particular to a medical material for inducing tissue repair, its preparation method and application. Background technique [0002] After developing and designing several generations of cardiovascular materials, there are still problems in late and very late arterial restenosis after material implantation. It is often necessary to promote the growth of surface cells on the surface of the product in the early stage, and to design anti-stenosis in the late and very late arteries to ensure the adaptability of the implanted material in the service environment. At the same time, it has an inert or even proliferative effect on smooth muscle cells to reduce the late stage and the emergence of very late arterial restenosis. [0003] The interventional stent materials currently used clinically are often not specific, and the implanted damage site is in urgent need of rapid repair due to t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L31/10A61L31/08A61L31/14A61L33/10
CPCA61L31/088A61L31/10A61L31/14A61L33/08A61L2300/412A61L2300/416A61L2300/418A61L2300/42A61L2300/602A61L2400/12A61L2400/18A61L2420/02A61L2420/04A61L2420/06A61L2420/08C08L77/04C08L5/10C08L79/02
Inventor 陈俊英曾峥谢银红李霞李莉谭建英王焕然魏来翁亚军黄楠
Owner SOUTHWEST JIAOTONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap