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A light control nanoparticle assembly and its preparation method and application

A nanoparticle assembly and nanoparticle technology, which is applied in the fields of wave energy or particle radiation treatment materials, drug combinations, and pharmaceutical formulations, can solve problems such as uncontrollable molecules, and achieve the effect of easy control and simple operation.

Active Publication Date: 2021-06-29
HUAZHONG UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention solves the uncontrollable technical problem in the prior art that the molecules coated by the nanoparticle assembly are released

Method used

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  • A light control nanoparticle assembly and its preparation method and application
  • A light control nanoparticle assembly and its preparation method and application
  • A light control nanoparticle assembly and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation method of gold nanoparticle vesicles for controlled drug release by ultraviolet light

[0036] This preparation method mainly comprises the following steps:

[0037] 1. Synthesis of photoresponsive polymer: It is worth noting that the photoresponsive group in the photoresponsive polymer is exemplified by coca isodioic acid, which can The four-membered ring will be broken, so that the hydrophilic and hydrophobic segments will be separated, and the chain structure of the polymer will be changed, so as to achieve the purpose of light-controlled drug release.

[0038] 1.1. Synthesis of the photoresponsive group: cinnamic acid was ring-closed under 365nm ultraviolet light irradiation to form the ultraviolet photoresponsive group coca-metadioic acid.

[0039] 1.2. Synthesis of polymers containing (S-S) bonds and coca ishalic acid:

[0040] 1.2.1. Synthesis of polystyrene (PS-coca-isodiacid) capped with coca-isodiacid:

[0041] (a) Monohydroxyl-termina...

Embodiment 6

[0068] Example 6 Disassembly test of gold nanoparticle vesicles releasing drugs in response to ultraviolet light

[0069] The gold nanoparticle vesicles that release drugs in response to ultraviolet light described in Example 1 were dispersed in water, and dynamic light scattering (DLS) was used to detect the disassembly process of the gold nanoparticle vesicles in real time. The particle size changes of the gold nanoparticle vesicles were monitored after 0min, 10min, 20min, and 30min of ultraviolet radiation, namely image 3 . The results showed that the vesicle size decreased successively after each UV irradiation, so the vesicle disassembly process could be further controlled by adjusting the UV irradiation time.

Embodiment 7

[0070] Example 7 Photothermal effect test of nanoparticle vesicles releasing drugs in response to ultraviolet light

[0071] The gold nanoparticle vesicles that release drugs in response to ultraviolet light described in Example 1 were dispersed in water, and their photothermal effects were measured at 0 μg / mL, 25 μg / mL, 50 μg / mL, 75 μg / mL, and 100 μg / mL ,Right now Figure 4 . The results showed that the photothermal effect of the gold nanoparticle vesicles was getting better and better with the increase of the concentration, which indicated that the gold nanoparticle vesicles had a better photothermal effect.

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Abstract

The invention discloses a light-controlled nanoparticle assembly, a preparation method and application thereof, and belongs to the field of drug controlled release. The optically controlled nanoparticle assembly of the present invention contains nanoparticles and a photoresponsive polymer; the photoresponsive polymer is grafted to the surface of the nanoparticle through coordination, host-guest interaction or covalent bond; the photoresponsive group is connected on the polymer backbone or side chains. The light-controlled nanoparticles self-assemble with the drug molecules to form a light-controlled nanoparticle assembly covering the drug molecules. Under light conditions, the light-responsive molecules on the polymer chain change, resulting in a change in the structure of the polymer chain, and the nanoparticles The assembly is disassembled to release the encapsulated drug molecules, realizing light-controlled drug release.

Description

technical field [0001] The invention belongs to the field of drug controlled release, and more specifically relates to a light-controlled nanoparticle assembly and its preparation method and application. Background technique [0002] Cancer (ie, malignant tumor) is one of the major diseases that endanger human health and life. Chemotherapy (i.e. chemotherapy), as one of the cancer treatment methods, has obstacles and toxic side effects to anticancer drugs due to the physical environment of the body, thus limiting the effect of chemotherapy to a large extent. In recent years, the rapid development of nano-drug delivery systems has greatly improved the efficiency of drugs reaching the lesion, bringing new opportunities for tumor treatment. Therefore, designing and preparing novel nano-drug delivery systems has gradually become one of the effective ways to treat tumors. [0003] In a series of new nano-drug delivery systems, functional hybrid nanomaterials combine the charact...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/32A61K47/34A61K47/10A61K31/137A61K31/255A61K31/337A61K31/704A61P35/00
CPCA61K9/5138A61K9/5146A61K9/5153A61K31/137A61K31/255A61K31/337A61K31/704A61K41/0042A61K41/0052A61P35/00A61K2300/00
Inventor 朱锦涛刘园园谭海英张连斌
Owner HUAZHONG UNIV OF SCI & TECH
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