The invention relates to a manufacturing method of a medical protective sintered breathable material with a sterilization channel. The medical protective sintered breathable material is formed by combining ultra-high molecular weight polyethylene powder, nano-silver ion powder and nano-titanium dioxide powder, the ultra-high molecular weight polyethylene powder selects a powder with the particle size of 360 nm, the nano-silver ion powder selects a powder with the particle size of 120 nm, and the nano-titanium dioxide powder selects a powder with the particle size of 240 nm. The breathable material comprises the raw materials in percentage by volume: + / -75% of the ultra-high molecular weight polyethylene powder, + / -15% of the nano silver ion powder and + / -10% of the nano titanium dioxide powder. In the manufacturing process of the breathable material, raw material proportioning, feeding, die assembly, sintering, heating, heat preservation and cooling are conducted, and then die stripping is conducted. A sintered microporous breathable material finished product with the sterilization channel and full penetration is formed, coronavirus is forced not to pass through, and even if the coronavirus passes through the channel, the coronavirus is fully killed by silver ions under the catalysis of nano titanium oxide, so that the breathable material can be used as a medical protective clothing material.