The invention discloses a method for efficient alkane selective catalytic oxidation reaction. Alkane is used as a raw material, copper salt-metal salt is used as a catalytic system in a trifluoroacetic acid and/or trifluoroacetic anhydride system, a reaction is carried out in the presence of an oxidizing agent, and a selective catalytic oxidation reaction is carried out, wherein the metal salt isone or more of lithium salt, sodium salt, potassium salt, cesium salt, calcium salt or magnesium salt. The metal salt is used as a catalyst auxiliary agent and is matched with the copper salt for useso that the reaction activity of the catalyst in alkane catalytic oxidation is remarkably improved, the use amount of the catalyst is remarkably reduced while the high yield of the product is guaranteed, and the catalytic efficiency of the catalyst is improved. Taking methane as an example, the trifluoroacetic acid methane is prepared by adopting the method, the highest yield is about 72%, and theselectivity is about 92%, the conditions of the reaction process are relatively mild, the reaction can be performed at 90 DEG C, and the obtained methyl trifluoroacetate can be subjected to various conversions according to literature methods, such as hydrolysis into trifluoroacetic acid and methanol.