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Fermented traditional Chinese medicine preparation and its preparation method and application

A technology of traditional Chinese medicine preparations and Chinese herbal medicines, applied in the directions of application, pharmaceutical formulations, drug combinations, etc., can solve the problems such as the inability to guarantee the efficacy and quality stability of Chinese herbal medicines, the low level of modernization of traditional Chinese medicine, and the slow pace of internationalization.

Active Publication Date: 2021-07-27
FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, despite the favorable situation of strong growth in the natural medicine market, the pace of internationalization is slow. In addition to the fact that the theory of traditional Chinese medicine and modern scientific theory cannot be well integrated, the fundamental reason is that the modernization level of traditional Chinese medicine is still low, and the processing of Chinese herbal medicine is still relatively low. and applications still need to be developed
[0004] China's fermentation technology has a long history of application, and it is also one of the important methods of Chinese medicine processing. However, traditional Chinese medicine fermentation uses natural strains such as mold, yeast and bacteria to ferment, due to factors such as lack of pertinence and difficult control of fermentation conditions. , the efficacy and quality stability of the herbal medicine after fermentation cannot be guaranteed

Method used

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  • Fermented traditional Chinese medicine preparation and its preparation method and application
  • Fermented traditional Chinese medicine preparation and its preparation method and application
  • Fermented traditional Chinese medicine preparation and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] A kind of fermented traditional Chinese medicine preparation and preparation method thereof

[0049] 1. Strains: Lactobacillus acidophilus.

[0050] 2. Mixed powder of compound Chinese herbal medicine: weigh 1 part of Codonopsis pilosula, 2 parts of Rehmannia glutinosa and 10 parts of soybean meal in parts by weight, dry Rehmannia glutinosa in an oven at 50°C-55°C for 3-4 hours, and mix with Codonopsis pilosula, Rehmannia glutinosa, After the soybean meal is mixed, it is pulverized and passed through a 60-mesh sieve to obtain a mixed powder, which is set aside.

[0051] 3. Medium formula

[0052] Activation medium: tryptone 10g, beef powder 5g, yeast powder 4g, glucose 20g, Tween 80 1mL, dimethyl hydrogen phosphate heptahydrate 2g, sodium acetate trihydrate 5g, triammonium citrate 2g, magnesium sulfate heptahydrate 0.2g , manganese sulfate tetrahydrate 0.05g, distilled water 1000mL, agar 15g, pH value 6.2.

[0053] Expansion medium: tryptone 10g, beef powder 5g, yeas...

Embodiment 2

[0069] Example 2 is basically the same as Example 1, except that the amount of mixed powder added to the fermentation medium and Chinese herbal medicines and the fermentation conditions are different, specifically:

[0070] The fermentation medium is: wheat bran 8g, peptone 10g, beef powder 6g, yeast powder 3g, glucose 12g, Tween 801.3mL, dipotassium hydrogen phosphate 2.5g, sodium acetate 6, triammonium citrate 3g, magnesium sulfate 0.2g, 0.05g of manganese sulfate, 1000mL of pure water; 12g of mixed powder of Chinese herbal medicine was added to 1L of fermentation medium.

[0071] The fermentation conditions are: temperature 38°C, pressure 0.06kPa, pH value 6.6, stirring speed 30r / min, culture time 38h.

Embodiment 3

[0073] Example 3 is basically the same as Example 1, except that the amount of mixed powder added to the fermentation medium and Chinese herbal medicines and the fermentation conditions are different, specifically:

[0074] The fermentation medium is: wheat bran 10g, peptone 8g, beef powder 6g, yeast powder 6g, glucose 13g, Tween 801.2mL, dipotassium hydrogen phosphate 2g, sodium acetate 5, triammonium citrate 2.5g, magnesium sulfate 0.18g, 0.08g of manganese sulfate, 1000mL of pure water; 16g of mixed powder of Chinese herbal medicine was added to 1L of fermentation medium.

[0075] The fermentation conditions are: temperature 36°C, pressure 0.05kpa, pH 6.4, stirring speed 30r / min, culture time 48h.

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Abstract

The invention relates to a fermented traditional Chinese medicine preparation and its preparation method and application. Among them, the preparation method of the fermented Chinese medicine preparation includes the following steps: pulverizing and sieving the Chinese herbal medicine to obtain a mixed powder; Ferment at 36°C-38°C for 24h-48h to obtain a fermentation mixture; filter the fermentation mixture, collect the filtrate and filter residue respectively; spray-dry the filtrate at 50°C-65°C to obtain the first powder; dry the filter residue, Pulverizing to obtain the second powder; uniformly mixing the first powder and the second powder to obtain the fermented traditional Chinese medicine preparation. The method uses probiotics to ferment the raw materials of Chinese herbal medicines, and uses low-temperature drying of the fermentation mixture, which can not only increase the content of effective active ingredients in the traditional Chinese medicine fermentation liquid, but also maintain the activity of probiotics in the product, and has the functions of enhancing the immune function of animals and promoting the healthy growth of animals role.

Description

technical field [0001] The invention relates to the technical field of poultry additives, in particular to a fermented traditional Chinese medicine preparation and its preparation method and application. Background technique [0002] About 100,000 tons of antibiotics are used in animal husbandry every year in my country, and 90% of antibiotics are used as feed additives. As a feed additive, antibiotics can promote animal growth and improve animal immunity, but excessive use of antibiotics will cause problems such as enhanced drug resistance of pathogenic bacteria and drug residues, which will cause major harm to animal husbandry and human health. With the rapid development of the feed industry, the issue of feed safety has attracted more and more attention. Fermented Chinese herbal feed additives that are pure natural, pollution-free, have no antibiotic residues, and have comprehensive functions have become a research hotspot at home and abroad. [0003] As the birthplace o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/804A61P37/04A61P1/14A23K50/30A23K10/12A23K10/30
CPCA61K36/344A61K36/804A61K2236/19A23K10/12A23K10/30A23K50/30A61P1/14A61P37/04A61K2300/00
Inventor 谢志恒李成应周淑贞付良凯陈静虹
Owner FOSHAN NANHAI EASTERN ALONG PHARMA CO LTD