Ion chromatography determination method of sodium, potassium, magnesium and calcium in compound amino acid injection
A compound amino acid, determination method technology, applied in the direction of measurement device, material separation, instrument, etc., can solve the problems of high detection cost, low accuracy, poor specificity, etc., achieve low detection cost, improve service life, improve stability and The effect of accuracy
Inactive Publication Date: 2019-03-22
中科谱研(广州)检测有限公司
View PDF7 Cites 3 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0007] The technical problem to be solved by the present invention is to overcome the disadvantages of poor specificity, poor stability, low accuracy, and high detection cost in the existing analysis and detection technology for the determination of sodium, potassium, magnesium, and calcium content in compound amino acid injection liquid.
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0045] Instruments and reagents
[0046] 940Professional IC Vario ion chromatograph (Swiss Metrohm company);
[0047] Ultrapure water (Milli-Q, U.S. Millipore Company);
[0048] Sodium single element standard solution (1000mg / L, manufacturer: China Institute of Metrology, GBW(E)080127, batch number: 17113);
[0049] Potassium single element standard solution (1000mg / L, manufacturer: China Institute of Metrology, GBW(E)080125, batch number: 17084);
[0050] Calcium single element standard solution (1000mg / L, manufacturer: China Institute of Metrology, GBW(E)080118, batch number: 17104);
[0051] Magnesium single element standard solution (1000mg / L, manufacturer: China Institute of Metrology, GBW(E)080126, batch number: 17101).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention provides an ion chromatography determination method of sodium, potassium, magnesium and calcium in a compound amino acid injection. An adopted stationary phase is silica gel or ethylvinyl-benzen-divinyl benzene polymer resin; a functional group is a cationic exchange column of carboxylic acid or phosphoric acid; a mobile phase is a mixed solution of an acid compound aqueous solutionand an organic solvent; good separation of the sodium, the potassium, the magnesium and the calcium from other coexistence components is ensure; in addition, accurate detection is carried out by adopting a conductivity detector. The method is simple, fast, accurate and reliable to operate, and has important practical value for quality control and use safety of the compound amino acid injection.
Description
technical field [0001] The invention relates to an ion chromatography determination method for sodium, potassium, magnesium and calcium in compound amino acid injection, and belongs to the technical field of detection. Background technique [0002] Compound amino acid injection (Amino Acid Compound Iniection) is formulated from L-amino acids, sugars (including sugar alcohols), vitamins, electrolytes, pH regulators and antioxidants. It is one of the commonly used parenteral nutrition preparations in clinical practice. Belongs to national essential medicines. Commonly added electrolyte types include sodium chloride, potassium chloride, calcium chloride, magnesium chloride, sodium sulfate, potassium sulfate, magnesium sulfate, sodium acetate, potassium acetate, etc. In addition, sodium hydroxide, potassium hydroxide, etc. are often used as pH regulators, and sodium metabisulfite, sodium bisulfite, etc. are often used as antioxidants. The addition of these salts or bases will ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 李仁勇梁立娜
Owner 中科谱研(广州)检测有限公司